Biomedical subjects
M C Gerald
Publications and source records attributed to M C Gerald.
Determination of femtomole levels of acetylcholine by an improved bioassay procedure.
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Acute and chronic effects of d- and 1-amphetamine on seizure susceptibility in mice.
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Comparative convulsant activity of various penicillins after intracerebral injection in mice.
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Effects of various antihistamines on oxotremorine-induced hypothermia in mice.
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Studies on the possible role of brain histamine in behaviour.
1. The possible role of brain histamine in behavioural performance was studied in rats using thirst-induced water consumption, continuous (Sidman) avoidance, and reinforcement withdrawal test systems.2. Parenteral administration of a variety of antihistamines to rats decreased thirst-induced water consumption; this effect could be antagonized by administration of histamine directly into the brain by a ventricular cannula.3. When intraventricular doses of histamine were administered to rats at weekly intervals, an adaptation was seen in the effects of the amine on continuous avoidance behaviour. With succeeding doses, the initial period of depression of avoidance responding was shortened and the subsequent rebound stimulation disappeared.4. The results support the hypothesis that histamine in the brain is involved in several behavioural phenomena.
Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems.
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L(S)- and D(R)-3-amino-1-phenylpyrrolidines. Stereoselective antagonists for histamine and acetylcholine receptors in vitro.
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Stimulation of liver microsomal drug metabolism in male and female mice by spironolactone and aldadiene.
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Pharmacological studies on the stereoselective antihistaminic and anticholinergic properties of L(S)- and D(R)-3-ethylamino-1-phenylpyrrolidine.
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Evidence for spironolactone as a possible inducer of liver microsomal enzymes in mice.
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Potentiation of oxotremorine lethality by antihistamines.
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Stimulation of barbiturate metabolism by spironolactone in mice.
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Evidence for peripheral cholinergic components in thrist-induced water consumption.
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Curare-like effects of the amphetamine isomers on neuromuscular transmission.
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d-Amphetamine effects on attention and memory in the albino and hooded rat.
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Physiological disposition and behavioral effects of chlorpromazine and other phenothiazine tranquilizers.
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