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Biomedical subjects

M C DODD

Publications and source records attributed to M C DODD.

At least 19 recordsLinked to original sources

Autoimmune response in rabbits injected with rat and rabbit liver ribosomes.

Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.

Animals↗

Specific inhibition of RHo(D) antibody by sialic acids.

Agglutination of Rh(O)(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

Antibodies↗