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Biomedical subjects

M C Cassone

Publications and source records attributed to M C Cassone.

33 records · Page 2Linked to original sources
PubMed1982

Modification of the synergism acetylcholine-eserine induced by morphine in amphibian muscle.

The modification of the synergism acetylcholine-eserine induced by two different concentrations of morphine (0.2 and 8 microgram/ml) was studied on the frog rectus abdominis muscle. Morphine increases the Ach-potentiating action of low concentrations of eserine (from 3 to 40 ng/ml). On the contrary at higher eserine concentrations (from 0.1 to 1.0 microgram/ml), morphine reduces the potentiation of Ach effects caused by eserine. It is concluded that in amphibian muscle eserine and morphine potentiate the effects of exogenous Ach by acting on the same population of receptors.

Abdominal Muscles↗
PubMed1980

[Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat].

The Chamomile, Cinnamon, Absinthium, Mace, Origanum essential oils have been experimented on rat's operant conditioning behaviour. At the highest doses all the oils caused a depressive effect (probably due to toxicity) while at the lowest doses they caused weak or doubtful effects. Only the Origanum oil caused a depressive effect which clearly seems related to a direct action on the CNS.

Animals↗
PubMed1980

[Hepatic and intestinal toxicity of furazan and furoxan derivatives].

Histological examination revealed that 4-methylfurazan-3-carboxylic acid hydrazide (I); 3-methylfuroxan-4-carboxylic acid hydrazide (II); 4-methylfurazan-3-carboxylic acid amide(III); 4-methylfuroxan-3-carboxylic acid amide (IV), caused hepatic and intestinal lesion in the mouse. At the higher doses a destruction of the intestinal mucosa and a vasodilatation of the hepatic sinusoid was observed. At lower doses hepatic steatosis was observed.

Animals↗
PubMed1975

[Some pharmacological actions of furazan hydrazides and of 2 correspondent furoxan derivatives].

A study has been made of the acute toxicity, action on the guinea pig ileum, on the ventricle edge, on frog spinal reflex, and on the respiratory and cardiac activity and pulse of the following compounds: 3-methyl-4-furazancarbohydrazide (I); 3-methyl-4-furoxancarbohydrazide (II); 4-methyl-3-furoxancarbohydrazide (III). The compounds had no action on guinea pig ileum or ventricle edge. Compound (I) showed depressant activity on frog spinal reflex whereas compound (II) showed excitation and compound (III) had no direct spinal action. The compounds tested affected respiration and ECG only at the highest doses used. The pulse rate was raised by substance (I) in all cases whereas substances (II) and (III) raised pulse rate only at low doses.

Animals↗