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Biomedical subjects

M C Bateson

Publications and source records attributed to M C Bateson.

At least 73 records · Page 4Linked to original sources
PubMed1984

Gallbladder disease and cholecystectomy rate are independently variable.

In Britain, gallstones can be expected to develop in 1 in 3 women and 1 in 5 men. Gallbladder disease in Dundee was more frequent in 1974-83 than in 1953-73. During 1961-81 the number of cholecystectomies trebled in Dundee and doubled in Scotland as a whole, but this could not be explained by changes in the prevalence of gallbladder disease. Between 1974 and 1983 in Dundee, 48 patients died of gallstone disease. 22 out of 54 (41%) patients with common bileduct stones at necropsy and 26 out of 1034 (2.5%) with gallbladder stones only at necropsy died from an associated cause. A further 26 died from gallbladder surgery without bileduct surgery. Gallbladder disease was not associated with death from myocardial infarction, and there was no relationship between gallstones and gallbladder cholesterolosis. 22 patients were found to have secondary carcinoma of the gallbladder and 17 were found to have primary carcinoma of the gallbladder at necropsy.

Adolescent↗
PubMed1983

Ursodeoxycholic acid for the dissolution of radiolucent gall bladder stones.

In a prospective dosage response study of 84 patients with radiolucent gall bladder stones treated with ursodeoxycholic acid (UDCA), a dose of 500 mg daily was as effective as 1,000 mg daily. Complete dissolution of stones was achieved in 9 of 31 patients (29%) treated for at least 6 months with the lower dose, and in 7 of 33 patients (21%) on the higher dose. 4 patients in each group continue on treatment having shown partial gall-stone dissolution. When the two dosage groups were considered together, small stones dissolved more readily than larger ones and, after allowance for stone size, success rates were equal in obese and non-obese patients. Treatment with UDCA was well tolerated and significant adverse effects were not encountered.

Adolescent↗
PubMed1981

Oesophageal epithelial ultrastructure after incubation with gastrointestinal fluids and their components.

Oesophageal biopsies from endoscopically normal patients were incubated in the following for up to 30 min-Ham's F10 medium:isotonic saline:0.1 N HCl:20, 2 and 0.2 mM bile acids:trypsin:pepsin:lipase; autologous gastric and duodenal juices. The biopsies were then examined by electron microscopy. No morphological change was produced by Ham's F10 or saline. HCl caused little damage. Gastric juice produced widespread severe damage, as did pepsin. Duodenal juice and the enzymes tested caused lysis and internalisation of desmosomes and peripheral cytoplasmic vacuolation. Bile acids split desmosomes and induced microvesiculation of cell membranes. Similar microvesiculation was also induced by duodenal juice. All media except hydrochloric acid eventually produced organelle damage and leaky and disrupted cells. The functional and superficial cells appeared to be able to withstand attack from these experimental media better then did prickle and basal cells. Membrane coating granules were secreted in the presence of hydrochloric acid, but not with enzymes.

Bile Acids and Salts↗
PubMed1981

Effects of bile acids and hydrogen ion on the fine structure of oesophageal epithelium.

Oesophageal mucosal biopsies were incubated in 20, 0, and 0.2mM solutions of cholic, chenodeoxycholic, ursodeoxycholic, and deoxycholic bile acids. Both conjugated and unconjugated bile acids were studied at pH 1 and 7 singly and in combination. Observations were also made using 0.1 N hydrochloric acid and human gastric juice at pH 1-3 and 7-8. After incubation for up to 15 minutes the mucosa was examined under transmission electron microscopy. We concluded that high and moderate concentration of all the common bile acids damaged the oesophagus irrespective of the pH, that low concentrations of bile acids were damaging only at high acid levels, and that damage to the epithelium did not occur when the pH of the gastric juice had been raised.

Bile Acids and Salts↗
PubMed1981

The association of oesophagitis with disease in the stomach and duodenum.

The records of all upper digestive endoscopies performed in one year in the Clinical Measurement Department of a teaching hospital serving a population of 250 000 were reviewed; 25% of patients had oesophagitis, which was usually associated with other significant findings such as peptic ulcer and gastroduodenal erosions. Only about 1 in 6 patients with oesophagitis had an endoscopically identified hiatus hernia. Oesophagitis was associated with gastric acid hypersecretion in both men and women.

Duodenal Diseases↗
PubMed1980

Ursodeoxycholic acid therapy and biliary lipids--a dose-response study.

The effects of four different doses of ursodeoxycholic acid (250, 500, 750, and 1000 mg daily) on biliary lipids were studied in 24 patients with radiolucent gallbladder stones. There was a significant increase in the proportion of ursodeoxycholic acid in bile after all doses, being greatest with 750 and 1000 mg daily. Unsulphated lithocholic acid was also increased in the bile after therapy, while the other major bile acids were reduced. The cholesterol content of bile was reduced by all doses, and this change was most marked after 1000 mg (from 10.9 +/- 1.4 to 5.6 +/- 0.5 mol%, P < 0.01). Biliary cholesterol saturation improved significantly only after 750 and 1000 mg daily.

Adolescent↗
PubMed1980

A comparative trial of liver biopsy needles.

A sheathed needle (Tru-Cut) was compared with a suction biopsy needle (Menghini) in a randomised prospective trial over 18 months to determine whether the former offered any special advantages in routine percutaneous liver biopsy. Seventy-seven consecutive biopsies were performed by a single operator. Although biopsy fragmentation was commoner with the suction needle, the length and volume of the largest core obtained was similar to results with the sheathed needle. Cytology provided useful additional information with the Menghini technique. The suction needle was repeatedly reusable and considerably cheaper than the sheathed needle, which may be used once only.

Biopsy, Needle↗
PubMed1980

Analysis of response to ursodeoxycholic acid for gallstone dissolution.

20 patients with radiolucent gallbladder stones were reviewed after 6 months' treatment with ursodeoxycholic acid (UDCA) at a dose of either 500 or 1,000 mg daily. Successful treatment could not be predicted from the patients' characteristics, nor from stone size or pre-treatment biliary lipid analysis. During treatment the bile in patients who responded to UDCA differed from bile in those who did not: mean cholesterol content was lower in responders (4.1 +/- 0.6 vs. 5.7 +/- 0.5 mol%, p less than 0.025) as was the lithogenic index (0.57 +/- 0.06 vs. 0.81 +/- 0.06, p less than 0.005) and the mean UDCA-corrected lithogenic index (0.79 +/- 0.10 vs. 1.04 +/- 0.07, p less than 0.05). However, the individual response could not be predicted from biliary lipid analysis during treatment.

Bile↗