Search PubMed⌕ Search

Biomedical subjects

M Busson

Publications and source records attributed to M Busson.

At least 55 records · Page 3Linked to original sources
PubMed1995

Analysis of cadaver donor criteria on the kidney transplant survival rate in 5,129 transplantations.

PURPOSE: To clarify the role of donor criteria we retrospectively analyzed a series of 5,129 cadaver kidney grafts harvested from January 1, 1989 to December 31, 1991. MATERIALS AND METHODS: Graft survival was calculated and analyzed using a multifactorial approach. RESULTS: Better graft survival was obtained with donors between 6 and 50 years old (80% versus 64% at 3 years), grafts performed from male donors (74% versus 69% at 3 years), donor deaths caused by cranial injury as opposed to cerebral hemorrhage (74% versus 70% at 3 years) and negative cytomegalovirus antibodies (75% versus 71% at 3 years). CONCLUSIONS: These factors may be used for kidney allocation.

Adolescent↗
PubMed1994

[Epidemiology and results of organ grafts].

Using the complete, multicentric Registry of organ transplantation in France, from 1970 to 1992, including 26,485 transplantations (kidney, heart, heart-lungs, lungs, liver), we studied four statistical parametres: 1. movement on the waiting list; 2. mean waiting time; 3. actuarial survival of the graft for the kidney, heart and liver; 4. number of recipients surviving with a functioning graft as of 31 December 1992. Patients awaiting a kidney transplant comprise a group that differs epidemiologically from the others on the basis of the length of the waiting list, entering and existing flux, and for the mortality rate of patients waiting for a graft. Similarly, the actuarial survival profile is different for the first year in kidney transplant recipients compared to the others.

France↗
PubMed1994

Absence of association between HLA antigens and chronicity of viral hepatitis in haemodialyzed patients.

The role of HLA antigens in the chronicity of viral hepatitis is still being debated. We analyzed the relation between HLA status and viral hepatitis in 558 consecutive haemodialyzed patients who underwent kidney transplantation. HLA A, B, DR status, ABO-Rh blood group, duration of haemodialysis, and number of blood units transfused during the dialysis period were known for all patients. Serological status for hepatitis B virus and hepatitis C virus and results of liver biopsies were available in 495, 300 and 316 patients, respectively. After correction for the number of tests performed, frequencies of HLA antigens did not differ significantly for: 1. hepatitis B virus infection (compared to HBsAg-positive and anti-HBc and/or anti-HBs-positive nonvaccinated patients); 2. hepatitis C virus infection (compared to anti-HCV-negative and -positive patients); 3. histopathological status (compared to patients who had chronic viral hepatitis and those who did not). These results suggest that there is no evidence for a significant role of a particular HLA antigen in the development of chronic viral hepatitis in haemodialysis patients with similar underlying immunosuppression and exposure to infection by hepatotropic viruses.

Adult↗
PubMed1992

Multifactorial analysis of the outcome of 6430 cadaver kidney grafts.

A total of 6430 cadaver kidney grafts performed within the network of France-Transplant between 1 January 1978 and 1 January 1989 were analyzed. Each case was examined comprehensively in regard to 12 variables. A multifactorial analysis (Cox regression) was used to determine the degree of association between each covariate and the outcome of the graft. The results were evaluated by calculating relative risks of graft failure for each variable. A total of seven covariates appeared to influence graft survival significantly: the period of transplantation (P = 10(-8)), retransplantations (P = 0.003), age and sex of the donor (P = 0.003 and 0.009 respectively), duration of pretransplant dialysis (P = 0.03), pretransplant sensitization to HLA antigens (P = 0.05), and matching for HLA-A, -B, and -DR loci (P = 0.03). This last parameter has previously been reported as influencing the outcome of the graft in seven out of eight international studies carried out using similar methodology.

Adolescent↗
PubMed1992

Life table analysis of the risk of type 1 (insulin-dependent) diabetes mellitus in siblings according to islet cell antibodies and HLA markers. An 8-year prospective study.

To determine whether genetic markers can improve the predictive value of islet cell antibodies for development of Type 1 (insulin-dependent) diabetes mellitus, 536 siblings aged 2-29 years were consecutively enrolled in a 8-year prospective survey. The risk of developing diabetes was estimated, using life-table methods, by years of follow-up and age, according to genetic factors (shared HLA-haplotypes, DR antigens, C4 allotypes) and islet cell antibody status. Fifteen siblings (2.8%) developed Type 1 diabetes during the study period (risk 4.4% after 8 years, 4% by age 22 years). DR3,4 heterozygosity identified higher risk (16% after 8 years, 12% by age 22 years, p less than 10(-5)) than HLA-identity (10% and 7%, respectively, p less than 0.01); risks for DR3 or DR4 positive and for haplo-identical siblings were low (4%, 3% and 4.4%, respectively, NS). C4BQO also conferred significant risk (11% vs 3% in non-C4BQO siblings, p less than 0.01). The predictive value of genetic markers alone was poor (12% for DR3,4, 7% for HLA-identity, 9% for C4BQO) compared with that of islet cell antibody levels greater than 4 Juvenile Diabetes Foundation units (41%, risk 56% after 8 years, p less than 10(-7)). HLA markers significantly contributed to risk prediction in combination with islet cell antibodies: islet cell antibody-positive DR3,4+ subjects had the highest risk (70% after 8 years, predictive value 58%, p less than 10(-7)) compared with islet cell antibody-positive DR3,4- (37% and 20%, respectively) and islet cell antibody-negative DR3,4+ (5% and 3.6%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

[Early graft failure. Methodology].

The French Transplantation Society and France-Transplant have conducted a collaborative study involving all French centers on the following subject: the early graft failure occurred within one month following transplantation. The data were collected in the France-Transplant network. Two groups of patients were compared for each risk factor according to the status of the graft at one month. This preliminary study is currently extended to multivariate analysis.

France↗