A steerable fiberoptic hysteroscope was developed with an integrated fluid circulatory system and a channel that can be used either for operative procedures or for the passage of a uterotubal occlusive device delivery assembly. The hysteroscope was demonstrated to be a safe and practical instrument for intrauterine observations, using the baboon as the animal model. Postpartum baboons were used for a majority of the experiments since the cervix of most cycling animals could not be sufficiently dilated to permit hysteroscope insertion. Estrogen-progesterone treatment resulted in softening of the cervix enough to allow hysteroscopic examination in 66 per cent of the animals so treated. Hysteroscopy was performed on 18 baboons. In almost all cases the uterotubal junctions were visualized and appeared as small slits or depressions. Measurements of the mean uterine length, fundal width, normal cervical diameter, and the diameter to which the cervix can maximally be dilated are reported for cycling, hormone-treated, and postpartum baboons.

Animals↗

PubMed1975

Manifest dream content: changes with the menstrual cycle.

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Adult↗

PubMed1975

Development of reversible vas deferens occlusive device: IV. Rigid prosthetic devices.

Different types of rigid, reversible, vas deferens occlusive devices were developed and evaluated in 14 unilaterally vasectomized dogs. All prosthetic devices had molded silicone rubber bodies, and rigid inflow and outflow tubes. Various techniques for the removal of the vas luminal epithelium, and for the preparation of porous ceramic and etched stainless steel surfaces to encourage tissue ingrowth into the prosthetic device end tubues were attempted. The devices differed in their methods of achieving occlusion. One device used a "rotary stem valve" which had a C-section rotating mechanism; the others used the "shuttle stem valve" which possessed an occlusive element that moved transverse to the axis of flow in the device, thus occluding the device when the stem was depressed. The rotarystem valve was implanted by means of a longitudinal incision. The remaining 13 shuttle stem devices were placed in the vas using either a longitudinal or a transverse implantation. Inno case was sperm transport through the prosthetic devices obtained for more than a few ejaculations.

Animals↗

PubMed1975

Development of reversible vas deferens occlusive device: V. Flexible prosthetic devices.

In contrast to the results with rigid-ended prosthetic devices implanted in the vas deferens of the dog, effective sperm transport was obtained for prolonged periods of time with flexible-ended (all soft) devices. Such transport could be halted by device occlusion with clips or shuttle stem valves. Opening the devices resulted once again in the passage of spermatozoa, indicating that these devices may be potentially useful as reversible male contraceptives. More research is necessary to determine the cause of an overall decrease in sperm output after device implantations and to evaluate any adverse side effects of such devices. Dacron velour-covered suture rings on the devices permitted effective tissue ingrowth and prevented leakage or recanalization.

Animals↗

PubMed1975

Information processing limits: the effects of information load and age.

As a test of the effects of age and information load Ss performed a visual and auditory discrimination task under conditions requiring division of attention. Amount of stimulus information was determined by the number of stimulus alternatives which could occur in a set of trials. Performance by 12 Ss over age 40 was impaired in comparison to 12Ss under age 40. Performance for all Ss was a function of amount of information, but there was no Age X Information Load interaction. It has been reported in the literature that age-related performance decrements are correlated with task complexity. These data indicate that amount of information is not a critical dimension of task complexity as it contributes to age-related performance deficits.

Adult↗

PubMed1974