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Biomedical subjects

M Buc

Publications and source records attributed to M Buc.

At least 91 records · Page 5Linked to original sources
PubMed1980

Are results of immunosuppressive therapy influenced by immunogenetic markers?

A group of 157 children, 4-15 years old, suffering from various forms of glomerulonephritis were investigated. Associations between the HLA system and the clinical, morphological and therapeutic responses were looked for. The study revealed the following associations: chronic GN to B15 and B18; Schönlein-Henoch GN to B27, Bw35 and Bw40; focal GN to B18; mesangioproliferative GN to B27; susceptibility to corticosteroids to B18; resistance to corticosteroids to B15.

Adolescent↗
PubMed1979

The frequency of HLA-Dw1 determinant in subacute (de Quervain's) thyroiditis.

Investigation of a group of 23 patients suffering from subacute (de Quervain's) thyroiditis for the frequency of the HLA-Dw1 determinant showed this determinatant to be more frequent--30.4%--compared to its frequency in a healthy population--19.1%. The finding is not statistically significant.

Chromosome Mapping↗
PubMed1978

[Laparoscopy].

Explore the source record for details and available documents.

Adult↗
PubMed1977

Subacute (de Quervain's) thyroiditis: association with HLA-Bw35 antigen and abnormalities of the complement system, immunoglobulins and other serum proteins.

The HLA antigens in 40 patients with subacute thyroiditis were investigated. An association between subacute thyroiditis and HLA-Bw35 antigen as previously reported, was confirmed. Further immunological observations included a decrease in Serum Clq, C4 and C3 activator levels; conversely, there was an increase in serum C3, IgM, alpha1-acid glycoprotein and alpha1-antitrypsin levels. Serum IgA levels were decreased in those patients who were Bw35 negative, but were normal in the patients who were Bw-35 positive, with serum alpha2-macroglobulin levels the opposite was found. These studies support the view that a genetic factor(s), viz., the major histocompatibility system, plays a role in the pathogenesis of subacute thyroiditis. A "nosological clustering" around the Bw35 antigen as a marker for viral susceptibility is suggested.

Adult↗