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Biomedical subjects

M Brunner

Publications and source records attributed to M Brunner.

172 records · Page 10Linked to original sources
PubMed1975

[A multidisciplinary study of infantile Steinert's syndrome].

The authors studied from several points of view 10 patients suffering from a neo-natal form of Steinert's disease. They analyse the variety of the family histories, of dysembryoplastic symptoms, of neo-natal difficulties and the subsequent impairment of mental development. They could not find any correlation between this latter evolution and the severity of the neurological damage, judged by the mentioned symptoms. They conclude that the mental retardation is proportional to the low quality of the early socio-emotional environment and believe that this hypothesis is confirmed by the fact that maxillo-facial malformations are mocise speech and mimicry in their early childhood.

Female↗
PubMed1972

Processing of adenovirus RNA before release from isolated nuclei.

Nuclei isolated from cultured human cells (KB) infected with adenovirus type-2 were used to study events occurring during the adenosine triphosphate-dependent release of viral RNA. When cells were labeled with [(3)H]uridine for 50 min beginning 18 hr after infection, most nuclear viral messenger RNA was in the form of high molecular weight precursors with sedimentation coefficients greater than 28 S. When nuclei were incubated in the presence of ATP and an ATP-generating system, labeled RNA the size of viral mRNA (10-29 S) was released. Cleavage of viral RNA precursor molecules of high molecular weight occurred during incubation of nuclei. The change in size of viral RNA did not require exogenous ATP and occurred before release of RNA from nuclei. This RNA cleavage seems comparable to processing of mRNA in vivo, for discrete viral species were produced. Cleavage was completed after 10 min of incubation but was not the rate-limiting step in the release reaction, which required about 20 min for completion.

Adenosine Triphosphate↗
PubMed1969

Bacteriophage release in a lysogenic strain of Agrobacterium tumefaciens.

Bacteriophage release in a lysogenic strain of Agrobacterium tumefaciens V-1 is temperature-sensitive. At 25 C and 30 C, phage was released in a ratio of 1 plaque-forming unit per 100 bacteria; at 35 C, although bacterial growth was not inhibited, phage release was suppressed. Phage synthesis was induced by heat shock, 42 C for 30 min, ultraviolet irradiation, and mitomycin C. Induction by ultraviolet light was unusual-an immediate rise in phage titer followed irradiation. A large increase occurred after a 90-min latent period. The lysogenic strain was cured of the phage by incubation at 37 C, and the cured strain produced plant tumors.

Bacteriolysis↗
PubMedDate not supplied

beta-lactam antibiotics in the treatment of neuroborreliosis in children: preliminary results.

In vitro beta-lactam antibiotics like ceftriaxone and penicillin G sodium have been shown to be active against Borrelia burgdorferi. Results of quantitative determinations of both antibiotic substances in the CSF for children are limited. Seventy-five children (median age 96 months, range 10 to 176 months) with probable or definite neuroborreliosis were treated with ceftriaxone (1 x 50-90 mg/kg/day) or penicillin G sodium (4 x 80,000-120,000 IU/kg/day) intravenously. On day 10 of therapy levels of penicillin G sodium (1,1.5,2,3,4, 5, or 6 h after i.v. administration), and ceftriaxone (1,2,4,6,12 or 24 h after i.v. administration) in serum and CSF were measured with a micro agar diffusion bioassay. Results demonstrate that after 5 h penicillin G sodium in CSF was above the minimal inhibitory concentration (MIC) but after 6 h penicillin G sodium levels were below the determination limit in 60% of the cases. All ceftriaxone results in CSF-even after 24 h-were above MIC. Penicillin G sodium serum values ranged from 46.6 to 0.1 mg/L (1 to 6 h post dose) and ceftriaxone serum values from 261 to 5 mg/l (1 to 24 h post dose). The role of penicillin G sodium and ceftriaxone and administration intervals of both antibiotics in the therapy of neuroborreliosis in children are discussed.

Adolescent↗
PubMedDate not supplied

VIPER: a general-purpose digital image-processing system applied to video microscopy.

This paper describes VIPER, the video image-processing system Erlangen. It consists of a general purpose microcomputer, commercially available image-processing hardware modules connected directly to the computer, video input/output-modules such as a TV camera, video recorders and monitors, and a software package. The modular structure and the capabilities of this system are explained. The software is user-friendly, menu-driven and performs image acquisition, transfers, greyscale processing, arithmetics, logical operations, filtering display, colour assignment, graphics, and a couple of management functions. More than 100 image-processing functions are implemented. They are available either by typing a key or by a simple call to the function-subroutine library in application programs. Examples are supplied in the area of biomedical research, e.g. in in-vivo microscopy.

Animals↗
PubMedDate not supplied

Identification of axons in the peri-implant region by immunohistochemistry.

In the edentulous patient with a completely implant-supported prosthesis, periodontal ligament receptors are absent. However, the implant patient's mandibular function during mastication and clenching is significantly improved and can be similar to that of dentulous subjects. The underlying mechanisms that govern this proprioceptive control are not well understood. One possibility that has been explored only partially is that residual axonal elements in the peri-implant region may have a proprioceptive function. To survey the peri-implant region for axonal elements, this study utilized immunohistochemistry with neurofilament as the marker. Histologic sections of the peri-implant area from 12 implants placed in the mandibles of three dogs were examined for the presence of neurofilament. Two to three labeled sites per section in the peri-implant region were commonly found. However, the functional significance of these axons must be further evaluated before any conclusions regarding their role in proprioception can be made.

Alveolar Process↗