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Biomedical subjects

M Brown

Publications and source records attributed to M Brown.

At least 703 records · Page 39Linked to original sources
PubMed1983

Blood monocytes and tumor-infiltrating macrophages in human breast cancer: differences in activation level as assessed by lysozyme content.

The lysozyme content of tumor-infiltrating macrophages (TIM) from human breast carcinomas has been compared with that of blood monocytes both from breast cancer patients and tumor-free controls. Cells were identified as macrophages or monocytes with the use of rosetting reactions to detect receptors for the Fc portion of IgG and differentiation antigens, and lysozyme was detected by an immunoperoxidase technique on cytocentrifuge preparations of rosetted cells. Significantly more monocytes from patients with breast cancer contained lysozyme than monocytes from comparable controls, suggesting the presence of activated circulating blood monocytes. Conversely, TIM were virtually devoid of lysozyme. This lack of enzyme was not due to methodologic factors and may represent defective antitumor activity.

Antigens, Surface↗
PubMed1983

Immediate postresuscitative care: Part I.

The areas that require attention in the period immediately after resuscitation include respiratory care, hemodynamic monitoring, and potentially lifesaving forms of definitive therapy such as intra-aortic balloon pump stabilization.

Acute Disease↗
PubMed1983

Sexual experience and plasma testosterone levels in male veterans after spinal cord injury.

Fifty men with spinal cord injuries (SCI) were asked to complete a questionnaire concerning their sexuality before and after injury. Medical examination confirmed the location and completeness of the injury and extracted information about genitourologic status. The respondents rated sexuality highly as a concern in living, and a wide variety of sexual techniques were reported. A marked decrease in sexual activity, satisfaction, and feelings of sexual adequacy was reported after injury, as compared to retrospective "before injury" responses, lack of opportunity being reported as causative by 66% of the subjects and insufficient personal satisfaction by 59%. Seventy-five percent of the subjects experienced sexual arousal from genital stimulation, and several methods of eliciting erection were cited. Orgasm was described by a variety of terms. Significant differences were found between quadriplegic and paraplegic patients in answers to several items, though there was generally no difference between cervical and thoracic groups, which were more specifically broken down with respect to motor or sensory/complete or incomplete lesions. Plasma testosterone levels were found to fall well within the normal adult male range, as were levels of free testosterone and serum sex binding protein. The resulting information demonstrated more sexual concern among men with SCI than the literature previously indicated.

Adult↗
PubMed1982

Multihospital systems in the '80s--the new shape of the health care industry.

Considering the major challenges that face hospitals during the 1980s--reimbursement shortfalls, capital acquisition, replacement of obsolete facilities, and more--it seems most likely that investor-owned and not-for-profit multihospital systems will begin to replace freestanding hospitals as the dominant organizational form in the health care industry.

Capital Financing↗
PubMed1982

Calcitonin effects on isolated bone cells.

Calcitonin decreased calcium uptake in specific rat bone cell populations obtained by sequential collagenase digestions of calvaria. The calcitonin effect on calcium uptake was observed in the same populations that manifested calcitonin-induced increases in cyclic AMP as well as high levels of acid phosphatase and the ability to release 45Ca from prelabeled devitalized bone. No effect of calcitonin was observed in cell populations that had high levels of alkaline phosphatase and lacked the potential to resorb devitalized bone. These results suggest that changes in cell calcium as well as cyclic AMP may be involved in the mode of action of calcitonin on osteoclast-like cells.

Acid Phosphatase↗
PubMed1982

A comparison between transient amnesias induced by two drugs (diazepam or lorazepam) and amnesia of organic origin.

The transient amnesias produced by drugs may have much in common with the more permanent amnesias associated with organic brain damage. This possibility was investigated using two benzodiazepines, diazepam and lorazepam, with medical student volunteers. In Experiment 1, 27 subjects received a 2ml intravenous injection of either diazepam (7.5 mg) or of lorazepam (3.0 mg) or of normal saline. In Experiment 2, a further 13 subjects were given lorazepam (2.5 mg) or saline. A double blind procedure was used. Neither drug had an appreciable effect on span-type short-term memory (except with 2-channel presentation). Both drugs produced severe anterograde amnesia in other forms of memory test: the amnesic effect of lorazepam lasted for several hours. This amnesia was not attributable to failures of perception. Lorazepam appeared to affect recognition even more than recall. In a test with lorazepam no evidence was obtained that the drug increases susceptibility to proactive interference. With both drugs, recall and recognition were unimpaired of material presented about 10 min before the injection; this shows that the drugs did not affect retrieval mechanisms.

Adult↗
PubMed1982

Interval sterilizations. A substitute for postpartum procedures, an example from Southeast Brazil.

From December 1979 to February 1980, data were collected on access to postpartum sterilization for all obstetric patients at a large maternity hospital in Campinas, Brazil. Of the 827 women wanting no additional children and having knowledge of sterilization, 481 (58%) reported that they wanted to be sterilized. Of these women, 226 (47%) were sterilized postpartum. One year following their deliveries, follow-up forms were administered to the women desiring sterilization, but who had not been sterilized postpartum, to determine if they had been sterilized over the course of the year. Only 13% of the women had been sterilized, but almost 75% of the women not sterilized said they were still interested in getting sterilized. Of the women interviewed, 18% either had become pregnant again since the initial survey or were currently pregnant.

Adult↗
PubMed1982

Comparison of morbidity in children requiring abdominal radiation and chemotherapy, with and without total parenteral nutrition.

We evaluated the effectiveness of total parenteral nutrition and placing the "bowel at rest," as compared to that of ad libitum food intake, on nutritional status and tolerance to combined chemotherapy and radiotherapy in a randomized, prospective trial in children with previously untreated malignancy requiring abdominal and pelvic irradiation and chemotherapy. Administration of TPN was found to be safe and efficacious in maintaining the children in good nutritional status during combined therapy; one-third of the control patients became malnourished and required TPN. There was no beneficial effect of "bowel at rest" and TPN on the ability of patients to tolerate combined therapies in terms of decreased toxicity; however, use of TPN was associated with improved adherence to chemotherapy schedules. Following termination of TPN or ad libitum food intake, and while receiving chemotherapy, the majority of the children who had previously received TPN lost significant weight. To date there has been no difference in mortality rate between the control and TPN groups. Although we conclude that TPN per se had little beneficial effect beyond that of maintaining good nutritional status, every child undergoing intensive combined therapy should have early and periodic assessments of nutritional status, so that the early signs of malnutrition can be detected, and the adverse effects of malnutrition can be prevented by nutritional replenishment, by TPN, or by other methods.

Abdominal Neoplasms↗