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Biomedical subjects

M Brody

Publications and source records attributed to M Brody.

At least 37 records · Page 2Linked to original sources
PubMed1980

Screening for congenital hypothyroidism in the Republic of Ireland.

A national pilot study for detecting congenital hypothyroidism by radioimmunoassay of thyroid-stimulating hormone concentrations in dried blood was incorporated into the newborn screening programme in Ireland on 1 August 1979. The programme has been monitored by a steering committee and follows the guidelines set by the European Society of Paediatric Endocrinologists. During the first 12 months 76 224 infants were screened and 19 cases confirmed, giving an incidence of 1:4012. Fifty infants (0.07%) were recalled for a serum sample, though most of the recalls (31; 0.04%) occurred during the first three months, before the methodology had become established. No case was detected clinically. At recall only three of the 19 affected infants had obvious features, and nine inconspicuous features. Organisation was directed at early diagnosis and treatment, the mean age at beginning treatment being 15 days. These results confirm the efficacy of screening for congenital hypothyroidism and suggest that capital and running costs will be offset by savings in maintenance treatment of untreated patients. Screening does not, however, remove the need for continued vigilance, and clinicians should request thyroid-function tests in any suspected case.

Age Factors↗
PubMed1979

Cerebrospinal fluid immunoglobulins in children.

Cerebrospinal fluid (CSF) immunoglobulins were measured in 62 normal children, in 9 children with purulent meningitis, and in 10 children with presumptive viral meningitis. The mean values in normal children were IgA 0, IgM 0, and IgG 0.84 +/- 1.4 mg/100 ml (+/- SD). The mean levels of all CSF immunoglobulins were raised in acute bacterial meningitis and were significantly greater than the levels found in viral meningitis. CSF IgM was 0.16 +/- 0.5 mg/100 ml in viral meningitis compared with 2.64 +/- 2.06 mg/100 ml in bacterial meningitis (P less than 0.01). However, these values overlapped to a considerable extent and, generally, measurement of CSF immunoglobulins did not enhance diagnostic accuracy in this group of children.

Cerebrospinal Fluid Proteins↗
PubMed1972

Direct and indirect mechanisms of deaggregation by fatty acids in chlorophyll-countaining systems.

The ability of an exogenous long-chain unsaturated fatty acid (linolenic acid) to induce changes in the circular dichroism (C.D.) spectra of chlorophyllous systems of various levels of organization is demonstrated and attributed to its deaggregating influence. In the case of chlorophyll in solution (CCl(4) or CCl(4)-hexane), deaggregation is by direct action on the chromophore. Evidence is also given for an indirect mechanism when chlorophyll is attached to protein (e.g., in HP-700 complexes); in this case, deaggregation results from a conformational change in the protein. Interpretations are given for the differences in C.D. spectra of nonmembranous and membranous chlorophyll-containing systems. (The latter include "digitonin-isolated" system I particles, subchloroplast particles obtained by means of sonication, and specially prepared intact chloroplasts.)

Alkanes↗
PubMed1971

The influence of two naturally occurring factors, from the leaves of Ricinus communis, on the fluorescence induction of higher plant chloroplasts and intact algae.

Changes in fluorescence induction, brought about by incubation of chloroplasts (Zea mays) in an aqueous extract of Ricinus leaf, have been divided, on the basis of speed of manifestation, into two categories: "fast" changes and "slow" changes (i.e. those observed after 5 min and 1(1/2) hr of incubation, respectively). The former, which include a large increase in the magnitude of the fast component of variable fluorescence and a retardation of decay from maximum to minimum levels of fluorescence, have been ascribed to inhibition of electron transport at a site beyond that of 3-(p-chlorophenyl)-1,1-dimethylurea (CMU)-i.e., towards system I; these changes result from the action of a fraction of the extract consisting of molecules of small size. The latter changes, which include a marked attenuation of the variable part of fluorescence induction, have been associated with system II and may arise from inhibition of electron flow between water and Q or from decrease in number of functional reaction centers; these changes result from the activity of a proteinaceous fraction of the extract, that simultaneously converts the low temperature steady-state emission spectrum of the chloroplasts into a one-banded one, with maximum at 698 nm.

Chlorophyta↗