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Biomedical subjects

M Broda

Publications and source records attributed to M Broda.

12 recordsLinked to original sources
PubMed2001

How RNA viruses exchange their genetic material.

One of the most unusual features of RNA viruses is their enormous genetic variability. Among the different processes contributing to the continuous generation of new viral variants RNA recombination is of special importance. This process has been observed for human, animal, plant and bacterial viruses. The collected data reveal a great susceptibility of RNA viruses to recombination. They also indicate that genetic RNA recombination (especially the nonhomologous one) is a major factor responsible for the emergence of new viral strains or species. Although the formation and accumulation of viral recombinants was observed in numerous RNA viruses, the molecular basis of this phenomenon was studied in only a few viral species. Among them, brome mosaic virus (BMV), a model (+)RNA virus offers the best opportunities to investigate various aspects of genetic RNA recombination in vivo. Unlike any other, the BMV-based system enables homologous and nonhomologous recombination studies at both the protein and RNA levels. As a consequence, BMV is the virus for which the structural requirements for genetic RNA recombination have been most precisely established. Nevertheless, the previously proposed model of genetic recombination in BMV still had one weakness: it could not really explain the role of RNA structure in nonhomologous recombination. Recent discoveries concerning the latter problem give us a chance to fill this gap. That is why in this review we present and thoroughly discuss all results concerning nonhomologous recombination in BMV that have been obtained until now.

Animals↗
PubMed1994

Genetic analysis of colon cancer susceptibility in mice.

Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q.

1,2-Dimethylhydrazine↗
PubMed1986

[Treatment with flicker stimulation of lesions of the visual cortex surface].

In this paper, the authors present the results of Flicker stimulation therapy in functional visual deficits secondary to occipital cortex lesions of miscellaneous origins. They formulate the hypothesis that the functional response obtained is subordinate to a variation or an integration of the macular cortical representation seat. Four cases were examined and the results obtained are significant.

Aged↗
PubMed1982

Diagnostic and therapeutic aspects of multiple sclerosis in urology: use of urodynamic methods of investigation.

Multiple sclerosis, one of the commonest neurological diseases, is associated in a large number of cases with micturition disorders in both its early stage and its later course. Urological complications play a decisive part in mortality. Urodynamic methods have greatly contributed to the diagnostic spectrum in this disease by permitting to demonstrate and classify neurogenic disorders of bladder function and providing the neurologist with closer information on the sites of the lesion. They are also apt to confirm diagnostic conjectures and may help to adapt the therapeutic measures to the special situation.

Adult↗
PubMed1982

[Survey of rehabilitation facilities with psychologic and therapeutic services in the Federal Republic of Germany].

Rehabilitation facilities (N=110) in the Federal Republic of Germany had been surveyed in order primarily to take stock of the psychological/psychotherapeutical services available for treatment in various disorders. The numbers of psychologists employed are shown to vary with the diagnostic groups served by the respective institutions. Facilities in the field of child and adolescent psychiatry, for the care of disabled person, and of persons with dependence problems are much better provided with psychologists than are facilities in the fields of psychiatry, neurology, and internal medicine. The same picture is found as regards the patients/psychologist ratios applicable in the different facilities. Preference of certain psychotherapeutical models (behavioural therapy, client-centered psychotherapy, psychoanalysis) varies with facility type. Especially noteworthy is an apparent predominance of inpatient services as opposed to outpatients models of service delivery. This fact is an indication of insufficient availability of follow-up care. Finally, various curricular aspects of the professional training of psychologists are outlined in relation to the recently established specialty of rehabilitation psychology.

Germany, West↗
PubMed1979

Plastic surgery in hydronephrosis (Indications and follow-up. Isotope nephrographic studies).

Surgical interventions for the reconstruction of the renal pelvis were performed in 108 cases between 1962 and 1974. On follow-up, 3 to 6 months after operation the results were found good or satisfactory in 54 cases (50%). Isotope nephrography revealed a good or satisfactory fall of the curve in the excretion phase in 49 out of the 54 cases (94%), distinct retention curves having been found in the remaining 6%. In 35% of these cases isotope nephrography showed a far more complete urinary drainage than it had been assumed on the ground of radiography. In 63% of the cases the results of the two diagnostic methods were congruent.

Adolescent↗
PubMedDate not supplied

[Development of a questionnaire for a standard follow-up assessment procedure for inpatient psychosomatic rehabilitation].

The paper establishes a follow-up assessment procedure for inpatient psychotherapy. It is suited for more than one theoretical approach or specific disorder. Using data from a larger follow-up-study, those items are identified that show substantial correlations with health and resource oriented questionnaires. In a second analysis, items are selected that predict therapeutic effects on parameters of health-behavior. This pool of items has to be completed by items constructed by plausibility criteria.

Adult↗
PubMedDate not supplied

[Combination of methods and integration of methods as standard in psychotherapy?].

Psychotherapy has undergone a relatively brief but nonetheless dramatic development, but this resulted in an enormous variety, extensive diversity, and good treatment possibilities. Can we say at this stage that the combination and integration of different methods in psychotherapy are today's standards? The authors, a psychoanalyst and a behavioural therapist, consider a greater transparency between the various therapeutic schools as a goal that must still be aimed at before methods can be combined. If such a combination is finally achieved, a standard psychotherapeutic treatment may evolve, since patients suffering from eating disorders, compulsive behaviour or anxiety would profit more from such treatment than from a merely "school"-oriented therapy. Initial ideas for achieving an integration of methods are discussed in respect of inherent limitations and risks.

Behavior Therapy↗