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Biomedical subjects

M Brochier

Publications and source records attributed to M Brochier.

At least 91 records · Page 5Linked to original sources
PubMed1978

["Torsades de pointe" and reentry induced by anti-arrhythmia agents].

Some anti-arrhythmic agents which have a stabilising effect on the membrane, particularly those belonging to Group I of Vaughan William's classification, are likely to cause rythmic disturbances by a re-entry phenomenon (atrial flutter 1/1, premature ventricular contractions, ventricular tachycardia, "torsades de pointe", even fatal ventricular fibrillation). The quinidines have been the most often condemned due to their effect on the action potential and on the speed of conduction. The fact that these re-entry phenomena are more frequent at therapeutic doses than at high or toxic doses suggests an individual susceptibility and the interaction of various predisposing factors: renal insufficiency, potassium depletion, pre-existing conduction disturbances, potentialsing drugs. In order to prevent these incidents it is advisable not to prescribe such anti-arrhythmic agents for susceptible patients, to control individual tolerance and to watch for the first ECG signs of conduction disturbances or of re-entry, such as premature contraction with fixed coupling. Treatment consists in an electrosystolic stimulus and the possible administration of potassium and bretylium.

Adrenergic beta-Antagonists↗
PubMed1976

[Unilateral auricular paralysis and dissociated ectopic auricular rhythm. Apropos of 4 cases].

The authors report four cases of right atrial palsy associated with tachycardia and/or slow atrial rhythm from the left auricle in elderly subjects with a past history of cardiac failure with atrial fibrillation for about ten years; they were digitalised and had cardiac failure, and in addition there was one perisinus block and one paroxysmal or persistant complete block situated above the bundle of His and probably above the AV node itself, secondary to the condition of atrial palsy. This probably represents an intermediate stage between chronic atrial fibrillation and atrial palsy in an elderly subject. These cases require careful intracavitary investigation, and often treatment by pacemaker and digitalis.

Aged↗
PubMed1975

[Treatment by urokinase of myocardial infarction and threatened infarction. Randomised study of 120 cases].

Two randomized series of 60 cases of myocardial infarction or menace syndrome have been treated at the acute stage, one by Heparin alone, the other by the combination Urokinase-Heparin. The average dosage was 300 mg Heparin in the first series, of 2,700,000 CTA units of Urokinase combined with 240 mg of Heparin in the second series. After the first 24 hours, equal heparinization was performed in both series up to the third week. Significantly different results were obtained in the two series. They favour Urokinase and concern: -- the disappearance time of pain, -- the course of the arrhythmias and of cardiac failure, -- the regression or limitation of the necrosis q waves and the lesion areas on the electrocardiogram. Finally the 30th-day overall mortality was 13% in the Heparin series and 3% in the myocardial infarction on the way of constitution, or which have done so for less than 24 hours.

Adult↗