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Biomedical subjects

M Brion

Publications and source records attributed to M Brion.

At least 19 recordsLinked to original sources
PubMed1992

Periodontal status in insulin-dependent diabetic adolescents.

A cross-sectional study was designed to evaluate the periodontal status of 85 12-18 year-old French adolescents with insulin-dependent diabetes (IDDM) and 38 healthy controls in the same age group. The clinical examination consisted of plaque control and gingival inflammation evaluation and probing attachment level. The interproximal marginal bone level was assessed with bitewing radiographs taken on the first molars and on areas presenting an attachment loss over 2 mm. Diabetic children had significantly more gingival inflammation than children without diabetes, in spite of similar plaque scores. No significant relation between gingival condition and age, Tanner's index, HbAlc level or disease duration could be demonstrated. None of the subjects had sites with attachment loss > or = 3 mm or radiographic signs of periodontitis.

Adolescent↗
PubMed1989

[New attachment formation with guided tissue regeneration. Review of the literature].

Restoring gum epithelial-conjunctive attachment on calcified tooth surfaces is the main objective of every treatment program of periodontal lesions. Research works are resulting today in a better understanding of biological mechanisms involved in tissue healing or rebuilding processes. These scientific studies allow to control such new therapeutics that can create a biocompatible environment essential to the metabolism of regenerating cells.

Animals↗
PubMed1989

[Adherent gingiva: therapeutic approaches as a function of different clinical situations].

Mucogingival surgery has been indicated for many years in cases of insufficiency or absence of attached gingiva. With time results of clinical studies have led to reconsidering this concept. Some authors today believe that systematic increase of attached gingiva is a therapeutic abuse. It is necessary to find a satisfactory attitude in the midst of this debate. Only the careful analysis of the clinical situation considered with the whole patient's dental problem can guide our clinical choice. Our attitude will be different if we are confronted with a natural dentition, prosthetic requirements on orthodontic movement.

Gingival Diseases↗
PubMed1985

Metal ion-tetracycline interactions in biological fluids. Part 5. Formation of zinc complexes with tetracycline and some of its derivatives and assessment of their biological significance.

A series of studies was previously devoted to the dependence of the bioavailability of various tetracyclines on their coordination with calcium and magnesium ions. Several clinical investigations have also shown zinc to interfere with the gastrointestinal absorption of the drug in humans. On the other hand, the administration of tetracycline to rats was reported to result in the increase of the elimination rate of zinc, which could originate in zinc-tetracycline interactions in blood plasma. Formation constants for zinc complexes with tetracycline, oxytetracycline, doxycycline, minocycline, chlortetracycline and demethylchlortetracycline were thus determined at 37 degrees C in NaCl 0.15 mol. dm-3 aqueous medium. Computer simulations were then carried out to investigate the drug influence on the distribution of the low-molecular-weight fraction of zinc in human blood plasma. Zinc-tetracycline interactions in the gastrointestinal fluid were also simulated, using clinical data relative to fasting subjects as taken from the literature. No significant effect can be expected from tetracyclines on the distribution of zinc in plasma at the usual therapeutic levels. However, zinc-tetracycline interactions have been found to be determining factors for the bioavailabilities of the metal as well as of the antibiotic in the gastrointestinal fluid.

Biological Availability↗
PubMed1984

[Bone surgery].

Explore the source record for details and available documents.

Alveolar Process↗
PubMed1984

Metal ion-tetracycline interactions in biological fluids. Part 3. Formation of mixed-metal ternary complexes of tetracycline, oxytetracycline, doxycycline and minocycline with calcium and magnesium, and their involvement in the bioavailability of these antibiotics in blood plasma.

The equilibria of the complexes formed separately by calcium and magnesium with tetracycline, oxytetracycline, doxycycline and minocycline were studied in the previous parts of this series. Computer simulations run on this occasion showed that the stoichiometry of these species do actually condition the bioavailability of the antibiotics in blood plasma during treatment, the fraction of free base being quite negligible with regard to the metal-bound one. The present paper completes this study with the investigation of the mixed-metal complexes given rise to by calcium and magnesium with the same antibiotics. Such ternary species have been proved to exist for tetracycline, oxytetracycline, and minocycline. Their involvement in the plasma distribution of these drugs is discussed, in relation with the potential abilities of the four tetracyclines to diffuse from plasma into tissue membranes.

Anti-Bacterial Agents↗
PubMed1983

Metal ion-tetracycline interactions in biological fluids. 2. Potentiometric study of magnesium complexes with tetracycline, oxytetracycline, doxycycline, and minocycline, and discussion of their possible influence on the bioavailability of these antibiotics in blood plasma.

The formation constants of the various complexes formed by magnesium with four tetracycline derivatives, namely, tetracycline itself, oxytetracycline, doxycycline, and minocycline, were determined by potentiometry over large pH ranges under experimental conditions pertaining to blood plasma (37 degrees C, NaCl 0.15 mol dm-3). The results were used, together with those previously obtained on the complexation of these tetracyclines with proton and calcium, to assess the influence of the two alkali earth metal ions on the bioavailability of these drugs in blood plasma. Accordingly, simulations of the distribution of the four tetracyclines into their different proton and metal complex species were calculated. The distributions confirm that, in combination with the protein-bound fraction of the tetracyclines, the metal-bound fraction represents more than 99% of these drugs in plasma, the extent of their free fraction commonly being less than 1%.

Biological Availability↗
PubMed1982

[Parasitic infestation and haemoglobinopathies in a population of 1170 refugees from South East Asia].

One thousand one hundred and seventy refugees from Cambodia, Laos and Vietnam were examined in the north of France from 1976 to 1980. 58% of them carried digestive parasites, 22% had anti-Plasmodium antibodies and 2% showed circulating Plasmodium. The most frequent parasites were hookworms (28%), Opisthorchiidae (15%) and Giardia intestinalis (12%). Strongyloides stercoralis (5,7%), Entamoeba histolytica (4,5%), tapeworms (3,3%), human coccidia (1,3%) and Trichostrongylus sp. (1%) were less frequent. Four cases of japonicum schistosomiasis were diagnosed by rectal biopsy. Three species of Plasmodium were identified: P. falciparum (10 cases), P. vivax (3 cases) and P. malariae (2 cases). 16% of the refugees displayed E haemoglobin (Hb E). The occurrence of parasitic infestation and Hb E were more frequent in Cambodians and Laotians than in Vietnameses. Specific anti-P. falciparum antibodies were observed with a significant higher frequency in patients carrying Hb E.

Adolescent↗
PubMed1982

[Corynebacterium endocarditis. Diagnostic difficulties (author's transl)].

The authors report a case of endocarditis due to Corynebacterium diphtheriae. THe bacteriological study is difficult since this micro-organism can be undistinguishable from a saprophytic diphtheroid. The observed case is compared to previously published observations. All have in common the great severity of the illness, and the high mortality rate. Despite the clinical symptoms and the cerebrospinal fluid (CSF) abnormalities, meningitic involvement could not be demonstrated.

Adult↗
PubMed1982

[Pneumococcal septicemia: 145 cases (author's transl)].

Over a six year period, 145 pneumococcal septicemias were seen at the Tourcoing Hospital. This represents 0.39% of all hospitalized patients and 19.8% of all septicemias seen over the same period. A mortality rate of 38.6% was recorded. Prognostic factors were analyzed. The mortality rate was significantly higher in women (46.5%), in patients admitted for a reason unrelated to the septicemia (50.8%), and in patients with septic shock (81.5%) which was frequent (22.8%). An underlying poor general condition was present in 88.2% of the patients. This confirms the high risk of pneumococcal infections in some patients who should be protected by vaccination.

Adolescent↗