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Biomedical subjects

M Briggs

Publications and source records attributed to M Briggs.

At least 145 records · Page 8Linked to original sources
PubMed1976

Molecular biology and oral contraception.

Recent developments in knowledge of sex hormone receptors and steroid analogue metabolism allow a rational selection of oral contraceptive steroids from among the numerous available products. Dose related metabolic effects of synthetic estrogens have been demonstrated. Many of these estrogenic actions are antagonised by norgestrel but not by any other commercially available progestogen. Generalised activation of lysosomal enzymes can be demonstrated in oral contraceptive users and is shown to be related to the total steroid dose per cycle, rather than to particular products. These findings suggest that the lowest dose combination of ethynylestradiol and d-norgestrel is the product of choice. Clinical results with such a product are described.

Blood Proteins↗
PubMed1975

The subunit structure of the cytochrome c oxidase complex.

The subunit structure of the cytochrome c oxidase complex has been obtained for three preparations each isolated by a different detergent procedure. Six polypeptides were present in all samples with the following molecular weights: subunits I, 36000; II, 22500, III, 17100; IV, 12500; V, 9700; and VI, 5300. These subunits have been purified by gel filtration in sodium dodecyl sulfate or in 6 M guanidine hydrochloride and their amino acid compositions have been determined. Subunit I is hydrophobic in character with a polarity of 35.7%. Subunits II through VI are more hydrophilic with polarities of 45.5, 48.6, 47.8, 49.7, and 53.7%, respectively.

Amino Acids↗
PubMed1975

Serum activity of lysosomal enzymes in relationship to contraceptive steroid dose.

Women using combined-type oral contraceptives show a progressive increase in serum activity of lysosomal enzymes (beta-glucuronidase and beta-acetyl-glucuronidase) during the first 6 cycles of treatment; thereafter, the enzyme activities remain relatively constant. The increase in enzyme activity appears to be approximately proportional to the total steroid intake per cycle and not to any particular steroid or combination of steroids. These findings suggest that oral contraceptives of choice should contain the minimum amount of steroids compatible with high efficacy and patient acceptability.

Adult↗