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Biomedical subjects

M Bretagnolle

Publications and source records attributed to M Bretagnolle.

32 records · Page 2Linked to original sources

[Hydatid cyst of the psoas muscle. Diagnosis using the CT scanner].

A 30-year-old Maroccan man was admitted with a swelling in the right iliac fossa and right flank. Serology gave negative results but ultrasonography and CT scan images were suggestive of a hydatid cyst of the psoas muscle. A cystectomy was followed by total recovery. Hydatid cysts are rarely detected in France and their clinical and diagnostic characteristics are discussed. Ultrasonography and particularly CT scaner imaging are effective diagnostic procedures, avoiding unnecessary needle punctures and enabling adequate therapeutic measures to be instituted.

Adult↗

[Treatment of cholestasis caused by stenosis of the intrahepatic bile ducts in alveolar echinococcosis. Trial of biliary drainage by the percutaneous transhepatic approach].

Six cases of hepatic alveolar echinococcosis with involvement of the hepatic hilum and cholestasis were treated by percutaneous biliary drainage. Clinical and morphological follow-up ranged from 18 to 34 months. A decrease of jaundice and bilirubinemia and the regression of the intrahepatic bile duct dilatation were observed in all cases. Biliary drainage was associated with percutaneous drainage of an hepatic necrotic cavity in four cases. Left hepatectomy was performed later in three cases. These results are encouraging and suggest that percutaneous biliary drainage is an effective and useful procedure for biliary drainage in hepatic alveolar echinococcosis with cholestasis due to obstruction of the intrahepatic bile ducts.

Adult↗

[Inferior vena cava thrombosis responsible for chronic Budd-Chiari syndrome during hepatic and digestive amyloidosis].

The case of a 39 year old woman with amyloidosis of the liver and the digestive tract presenting with obstruction of the inferior vena cava is reported. Computed tomography after bolus injection of contrast material revealed a typical patchy fan-shaped image, of hepatic vein obstruction. The association of Budd-Chiari's syndrome with amyloidosis may be related to the increased risk of thrombosis observed in the latter disease.

Adult↗

Percutaneous fine needle biopsy (P.F.N.B.) of intra-abdominal lesions.

Four hundred and seventeen percutaneous fine needle biopsies (P.F.N.B) have been performed in 405 patients. Two hundred and thirteen had a focal lesion of the liver, 116 a lesion of the pancreas, 74 an abdominal mass and 14 miscellaneous lesions. Real-time ultrasound has been used as a method of guidance in 90% of cases, fluoroscopy in 7% and computed tomography (CT) in 3%. The main indication for P.F.N.B. was detection of malignant lesions which represent 70% of the 338 proven cases. In these 338 cases, P.F.N.B. was successful in 310 (92%) and results were non-conclusive in 28 (8%). Sensitivity of P.F.N.B. in detection of malignancy of the liver, pancreas of abdominal masses was respectively 92%, 77% and 85%. Specificity was respectively 100%, 100% and 94%. Non-malignant lesions included benign solid tumours, cystic lesions or abscesses. Three symptomatic complications occurred in the 405 patients (0.75%). P.F.N.B. complements imaging procedures, especially real-time ultrasound, in obtaining a specific diagnosis of focal lesions within the abdomen.

Abdominal Neoplasms↗

[Value of intraductal biopsies and intraductal cytology in the etiological diagnosis of biliary stenoses].

Endobiliairy tissue specimens were obtained for cytologic and histologic examinations at the site of stenosis after percutaneous biliary drainage or endoscopic retrograde sphincterotomy in 49 patients with benign (10 cases) or malignant (39 cases) biliary stricture. Final etiologic diagnosis was obtained by surgery (18 cases), autopsy (one case), aspiration cytology of metastasis (2 cases), serology (2 cases), and in 26 cases, was determined by the course and outcome of the disease. As the sensitivity of each method, cytology and histology, was weak, it was necessary to associate them to improve results. Accurate etiologic diagnosis was achieved in 77 p. 100 of cases. The specificity of the method was satisfactory and specimen examination allowed to correct and confirm the initial etiologic diagnosis in 12 and 65 p. 100 of cases, respectively. The specificity of the method and its low morbidity prompt us to recommend it during transhepatic or retrograde therapeutic drainage as it can serve as a guide for later treatment. On the other hand, achievement of a transhepatic drainage or an endoscopic sphincterotomy only to obtain endobiliairy tissue specimens means taking into account the poor sensitivity of the method and the complications inherent to transhepatic drainage and endoscopic sphincterotomy. The practice of obtaining specimens by the retrograde technique without sphincterotomy or under cholangioscopy should be developed.

Adult↗

[Diagnostic and therapeutic strategy in carcinoma of the extrahepatic bile ducts].

The preoperative diagnostic approach in 25 patients with bile duct carcinoma was studied. Investigation procedures included gray-scale ultrasonography with guided fine needle biopsy of focal lesions, percutaneous transhepatic or retrograde cholangiography, transhepatic biliary drainage with brush and forceps biopsy of biliary stenosis as well as selective angiography for feasibility of surgical resection. Diagnosis was ensured in 23 patients by cytologic or histologic tissue specimens. Twenty-one lesions were judged unresectable on the basis of bile duct or vascular tumor extension and patient status. These patients were treated either by iridium 192 wire radiation therapy (6 cases) or by nonsurgical biliary drainage. Four patients with a potentially resectable tumor underwent surgery. This preoperative diagnostic approach can be recommended for selecting appropriate therapy in patients with bile duct carcinoma.

Adenocarcinoma↗