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Biomedical subjects

M Breckwoldt

Publications and source records attributed to M Breckwoldt.

At least 181 records · Page 10Linked to original sources

[New aspects in the treatment of puerperal mastitis (author's transl)].

36 women with postpartal breast engorgement were treated with a single oral dose of 2.5 mg bromocriptine (Pravidel). Significant relief was recorded in 28 patients, 6 patients required a second dose of 2.5 mg bromocriptine, whereas 2 patients failed to respond. Antibiotics were at first avoided in the treatment of puerperal mastitis. 26 patients with all characteristics of breast inflammation were treated exclusively with bromocriptine: for 3 days 2.5 mg t.i.d., for the following 11 days 2.5 mg twice daily. The temperature dropped below 37C in 25 patients within 12-24 hours, tension and pain disappearing simultaneously. One patient did not respond after 36 hours, so that an antibiotic was administered additionally; in another patient who had been admitted to the hospital six days after the onset of the clinical symptoms of breast inflammation, bromocriptine failed to prevent abscess formation. The results indicate that in most cases of puerperal breast inflammation no antibiotics are required. Puerperal mastitis can be treated effectively by the exclusive administration of bromocriptine.

Abscess↗

[Treatment of delayed labour with prostaglandin E2 (author's transl)].

26 patients suffering from delayed labour at term were treated with Prostaglandine E2 (PGE2). The compound was administered i.v. in a dosage of 0,5-1,0 microgram/min. Delivery was completed in 20 patients approximately 5 hours after starting the PGE2-infusion. In 6 patients delivery had to be performed by caesarean section, 4 times because of maternal and 2 times of fetal indications. In none of the cases uterine hypertension was recorded. The rate of side effects was negligible.

Adult↗

[Prostaglandin-F-levels in human plasma during late pregnancy and labour (author's transl)].

The concentrations of prostaglandin F-equivalents were measured in peripheral plasma during labour at a cervical dilatation of 5 cm and at complete dilatation. After purification, extraction and chromatography the PGF-equivalents were measured radioimmunologically. The intraassay variation was 1.5%, the interassay variation 3.5%. The specificity for PGF was 96-98%. Logit/log transformation of the standardcurve yielded a sensitivity of the assay of 120 pg. At cervical dilatation of 5 cm PGF-equivalents varied between 1300 and 3200 pg/ml plasma. At complete dilatation values changed between 1200 and 5400 pg/ml. These fluctuations correlate timedepending to the uterine contractions recorded and may be interpreted as a result of uterine PGF-release.

Cervix Uteri↗