Search PubMed⌕ Search

Biomedical subjects

M Brado

Publications and source records attributed to M Brado.

25 records · Page 2Linked to original sources
PubMed1994

[Stent angioplasty of the intrarenal aorta and aortic bifurcation. Clinical and angiographical results of a prospective study].

PURPOSE: The study was carried out to evaluate clinical and technical success, early and late complications and patency rates after stent angioplasty of atherosclerotic stenoses and occlusions of the infrarenal abdominal aorta and aortic bifurcation. PATIENTS AND METHODS: This was a prospective study in 20 consecutive patients treated by implantation of balloon-expandable stents. All patients were followed-up after 6 and 12 months and at yearly intervals thereafter by physical examination, Doppler sonography and angiography. RESULTS: Nineteen of 20 patients had clinical and technical success. In two patients clinically relevant complications occurred. During a mean observation time of 19 months (range 3-51 months) restenosis occurred in one stent after 15 months and was successfully treated by balloon angioplasty. Two patients became symptomatic again due to new atherosclerotic disease. CONCLUSIONS: Percutaneous stent angioplasty of the infrarenal aorta and aortic bifurcation yields high immediate and mid-term success rates with primary patency of 90% and secondary patency of 95%. These results are slightly better than those with balloon angioplasty, but the limited number of patients in our and others' studies does not yet justify general recommendations.

Adult↗
PubMed1994

[Transjugular intrahepatic portasystemic stent shunt (TIPSS). Technique of implantation].

Implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS) is guided by ultrasound and fluoroscopy. Today this stent is clinically established as a concept of "minimal invasive therapy" to treat recurrent variceal bleeding in patients with portal hypertension. We describe its technical steps in detail, giving the materials used. "Intraoperative" and "postoperative" monitoring and the typical features of an ideal shunt are described.

Catheterization↗
PubMed1994

[Long-term results after TIPSS with the Palmaz stent].

Since our first clinically successful TIPSS procedure in 1988 numerous steps to improve the safety and methodology have helped to increase the technical and clinical success while the rate of complications could be significantly reduced. In our series of more than 200 patients the technical success rate is more than 95% and the early clinical success rate (< 30 days after TIPSS) 89%, respectively. Early shunt occlusion was found in 1.5% of our patients. 3 months after TIPSS, however, transjugular portography reveals significant shunt stenosis in 46% needing either shunt re-dilatation or additional stent placement. This relatively high rate of re-intervention is being significantly reduced during the further follow-up with a frequency of 17% at a 6 month interval and 6% at a 12 month interval, respectively. The need for re-intervention is strongly associated with liver function and the patients' coagulation status: Child's A patients needed re-intervention substantially more often than those in stage B or C at each given follow-up interval. The decreasing need for re-intervention over time appears to be associated with the formation of an endothelial cell layer on the surface of the shunt tract.

Catheterization↗
PubMed1993

[The role of embolization treatment of acute hemorrhage].

137 arteries of 95 patients were treated by transcatheter embolization for massive haemorrhage using Ethibloc, Gelfoam, wire coils and Tissucol (Fibrinogen + Thrombin). The bleeding was secondary to trauma in 23 patients, to neoplasms in 16 patients and to vascular malformations or chronic inflammatory processes in 41 cases. 15 patients were treated for iatrogenic bleeding following surgery. Bleeding was referred to haemoptysis (n = 27), pelvic (n = 24), renal (n = 16) or gastrointestinal haemorrhage (n = 13) as well as several other diseases (n = 15). Most patients were poor surgical candidates. The overall bleeding control rate was 89.5% with a incidence of recurrent bleeding in 14 out of 95 patients (14.7%) treated by re-embolization or surgery. 6 patients died (6.3%) due to intractable haemorrhage, 4 patients (4.2%) died of complications related to embolization procedure (4 x bowel infarction!) and 33 patients (34.7%) died of procedure-unrelated causes such as myocardial infarction, trauma, malignancy or other underlying diseases. 58 patients (61.1%) are still alive (follow-up 16.2 +/- 4.8 months). Significant complications (5.3%) included bowel necrosis (4x) and ischaemia of the spinal cord with incomplete paralysis in one patient. One patient suffered thrombosis of the common iliac artery due to angiography. On the basis of our results, peripheral embolization using Ethibloc can be recommended as palliative treatment for devascularisation of bleeding tumours. Satisfactory results are obtained in haemoptysis, renal and pelvic haemorrhage, but gastrointestinal bleeding should not be occluded by means of Ethibloc because of its considerable risk of bowel infarction.

Acute Disease↗
PubMed1993

[Modified presentation of a lung embolism by a rare variant of pulmonary vein anomalous connection].

Partial anomalous pulmonary venous return of the left lung is an extremely rare cardiovascular abnormality. Mostly, this rare entity is found incidentally when patients undergo angiography of the pulmonary artery because of suspected pulmonary embolism. In this case hemodynamic data obtained by a swan ganz catheter suggested a cardiovascular abnormality presenting as left-right shunt. Surgical therapy of anomalous venous return of the left lung is only required if volume overload of the left ventricle occurs.

Aged↗
PubMed1988

Immunological mechanisms giving rise to latency of herpes simplex virus in the spinal ganglia of the mouse.

In the model of genital herpes simplex virus (HSV)-infection of mice, early latency could be induced by passive immunization with HSV-specific antibodies and, to a lesser degree, by adoptive transfer of immune lymphocytes prepared from spleen and draining lymph nodes of genitally infected syngeneic mice. Conversely, spontaneously occurring latency was inhibited by treatment of the animals with cyclophosphamide (Cph) and, to a lesser degree, with cyclosporin A (CyA). Whereas the effect of CyA could be compensated by passively administered HSV-specific antibodies, that of Cph could not. Apparently specific antibodies cooperate with a non-specific proliferating cell type, probably macrophages and/or NK-cells, as could be demonstrated by significantly reduced antibody effect in silica-treated mice. Moreover, F(ab)2 fragments, in contrast to complete antibody molecules, were inactive. HSV-specific antibodies and also immune lymphocytes had little effect on virus production in the mucous membranes, immune lymphocytes being at least as active as antibodies. It is therefore not probable that latency is induced by attenuation of the peripheral disease. It can rather be concluded that the neuron itself is the target for the action of specific antibodies, cooperating in turn with macrophages and/or NK cells.

Animals↗