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Biomedical subjects

M Boyer

Publications and source records attributed to M Boyer.

At least 109 records · Page 6Linked to original sources
PubMed1985

Hickman catheter tip displacement.

In a series of 60 consecutive patients in whom Hickman catheters were placed for treatment of malignancy, four properly positioned catheter tips migrated secondarily from the superior vena cava to the ipsilateral jugular vein 2, 4, 21, and 25 days after placement. Three of the four patients had begun to have catheter dysfunction when the displacement was diagnosed. No satisfactory explanation for this rarely reported complication was evident in three of the cases. Maneuvers such as coughing, Valsalva's maneuver, and forceful heparin flushing produced no motion in three normally directed catheter tips in other patients observed under fluoroscopy. The phenomenon may be more common than previously reported. Evaluation of any new Hickman catheter dysfunction should include a chest x-ray film to ascertain the position of the catheter.

Adult↗
PubMed1985

Fine specificity of antigen recognition by T cell hybridoma clones specific for poly-18: a synthetic polypeptide antigen of defined sequence and conformation.

Antigen-specific T cell blasts to poly-18, a polypeptide antigen of defined sequence and conformation, were generated from lymph nodes of antigen-primed BALB/cCr mice. These blasts were fused with the BW5147 thymoma to obtain anti-poly-18-reactive T cell hybridomas. All of the hybridomas were IAd-restricted and secreted IL2 in the presence of IAd/poly-18. On the basis of fine specificity analysis, these hybridomas were classified into two groups. Group A hybridomas recognized a minimal peptide sequence of Glu-Tyr-Lys-(Glu-Tyr-Ala)3-Glu-Tyr-Lys, whereas Group B needed the sequence Glu-Tyr-Ala-(Glu-Tyr-Ala)3-Glu-Tyr-Lys/Ala for activation. Three critical residues were identified in Group A hybridomas: the alanine residue at position 9, the carboxy terminal lysine, and the lysine at position 3. In Group B hybridomas, the alanine at position 3 was found to be the critical residue. We suggest that the amino acid residue at position 3 (lysine/alanine) is the T cell receptor contact residue on the poly-18 antigen in BALB/cCr mice.

Amino Acid Sequence↗
PubMed1984

[Cutaneous immunofluorescence in B virus diseases. 100 cases].

Immunofluorescence tests in healthy skin were performed in 75 patients with hepatitis B virus diseases (group I), in 25 HBs-antigen negative patients with the same diseases (group II) and in 90 controls (group III). HB virus diseases included acute, prolonged hepatitis; chronic, persistent and active hepatitis; cirrhosis and periarteritis nodosa. The immunofluorescence test was positive (micro- or macrogranular deposits in the walls of dermal vessels of HBs-antigen associated or not with immunoglobulins and complement) in 8 patients of group I (prolonged hepatitis 1; chronic persistent hepatitis 2; chronic active hepatitis 3; periarteritis nodosa 2), 3 of whom had no clinical manifestations, and in 3 patients of group II (chronic active hepatitis 2, periarteritis nodosa 1). Although not all patients with extrahepatic HB virus disease have a skin test positive for HBs-antigen and, conversely, a positive skin test does not necessarily imply clinical manifestations, it seems that skin immunofluorescence should be systematically performed as part of immunological investigations in all diseases where the HB virus might be involved.

Acute Disease↗
PubMed1984

[Noncompressive myelopathy and dysglobulinemia. A fortuitous association? Discussion of 3 new cases].

Three new cases of myelopathy without compression associated with paraproteinemia are reported. The neurologic picture was that of spinal muscular atrophy in one case and chronic spinal combined sclerosis in two. The nature of the paraproteinemia is discussed: all three patients seem to have had benign monoclonal dysglobulinemia. One patient died from cardiovascular disease five years after onset, and another from complications related to decubitus seven years after onset. Postmortem examination was not possible in either case. Spinal muscular atrophy has been reported in certain carcinomas (lung, stomach, breast) and, less frequently, in macroglobulinemia. As benign dysglobulinemia is common after sixty, coincidental association cannot be outruled. However, data from the literature and the response to cancer chemotherapy in two patients suggest an original pathologic association. Recent demonstration of demyelinating neuropathies associated with benign paraproteinemia provide further evidence in support of such an association.

Aged↗
PubMed1984

[Technic for assaying cefotaxime and desacetylcefotaxime in serum by high performance liquid chromatography].

Different high performance liquid chromatography (HPLC) methods for determination of cefotaxime (Ctx) and desacetyl cefotaxime (D-Ctx) are used. The method described presents the following advantages: a fast extraction and efficient deproteinization of serum samples are achieved with Sep-Pak cartridges; the mobile phase is a mixture of methanol - bidistilled water - acetic acid which permits the simultaneous dosage of Ctx and D-Ctx under the same chromatographic process. The retention times are respectively 7 mn 05 s and 10 mn 40 s for D-Ctx and Ctx. The results of 92 assays were compared with microbiological procedures.

Cefotaxime↗
PubMed1983

Induction by chemically modified actin derivatives of antibody specificity. A relation between modified sites and antibody interactions with monomeric and filamentous actins.

A comparison of specific antibodies induced by unfolded actins modified either by oxidation or by arylation of lysine residues was reported. We have focused our work on binding properties with filamentous actin and located its preferential antigenic sites for the anti-arylated-actin antibodies in the C-part of the molecule. An interference of anti-oxidized actin antibodies upon actin polymerisation has also been reported.

Actins↗
PubMed1982

Comparison of two teaching methods for self-care training for patients with chronic obstructive pulmonary disease.

Group instruction in self care is a widely used adjunct to the medical management of chronic obstructive pulmonary disease (COPD). Such classes are neither convenient nor accessible to all COPD patients, however, especially those in rural areas. A self-teaching module could be a practical means of serving hard-to-reach patients. This study compares the results of a self-teaching module with those of an established group method in teaching 13 self-care skills to COPD patients. On referral from their physicians, patients in eight rural locations were randomly assigned to receive training through a group or a self-teaching process. Knowledge gain, skill attainment, skill implementation, and beneficial results were measured at the end of instruction and again six months later. The two teaching methods were compared by analyzing the data on 34 patients matched for the variables of smoking, diagnosis, and severity of disease. No statistically significant difference was observed between the two educational methods in any of the parameters measured. The fact that approximately three out of four patients benefited through either process suggests that the self-teaching module is as effective as group instruction.

Hospital Bed Capacity, 500 and over↗
PubMed1982

Isolation and structural properties of a high-molecular-weight actin-binding protein (filamin-like protein) in hog thyroid gland.

A high-molecular-weight protein has been isolated from hog thyroid gland. This protein, with a molecular weight of 475,000 determined by ultracentrifugation and gel filtration, is a complex of two polypeptides with apparent molecular weights of 250,000 and 240,000. It may be related to filamin-like proteins by its physicochemical properties and its immunogenic cross-reactivity towards gizzard filamin antibodies. Furthermore it interacts with F-actin in a stoichiometry of 1 mol of high-molecular-weight protein/approximately 12-14 mol actin monomer allowing microfilament association, as shown by electron microscopy.

Animals↗
PubMed1981

[Articular infections in adults. Peripheral and vertebral involvement with common bacteria and tubercle bacteria].

2,166 cases of joint infection in adults were reviewed during a national inquiry. The peripheral infections due to common germs (1,080 cases) and tubercle bacilli (260 cases) were characterised by their frequency after the age of 60, the role of corticotherapy in onset of the infection and the predominance of staphylococci (60%) in pyogenic infections, the low proportion of deaths (4%) and the necessity of early treatment to observe better functional results. The vertebral lesions due to common bacteria (491 cases) were mainly localised in the lumbar regions (70%) whereas tuberculous infections (335 cases) usually affect the lower dorsal vertebrae (50%). Neurological signs and abscess were more frequent during tuberculous involvement. Needle puncture of the vertebral focus should be recommended owing to its help in etiological diagnosis. A cure was generally obtained without operation in the form of complete or incomplete block, this appearance is, however, less frequent than radiological signs of fixed osteolysis. The mortality is just as low as in peripheral infections.

Adolescent↗