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Biomedical subjects

M Bowers

Publications and source records attributed to M Bowers.

At least 37 records · Page 2Linked to original sources
PubMed1997

Needle exchange.

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Government Agencies↗
PubMed1997

Medical marijuana.

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Acquired Immunodeficiency Syndrome↗
PubMed1997

Hydroxyurea.

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Alopecia↗
PubMed1997

Diarrhea.

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AIDS-Related Opportunistic Infections↗
PubMed1996

Neutrophil activation during cardiopulmonary bypass in paediatric and adult patients.

It has been reported that the 'systemic inflammatory' response occurring during cardiopulmonary bypass (CPB) may be responsible for postoperative complications. This inflammatory response is triggered by the platelet coagulation system, complement activation, resulting in neutrophil activation and degranulation. The aim of this study was to quantify the specific markers of neutrophil activation in the adult and paediatric patient during CPB. We report that neutrophil myeloperoxidase (MPO) and human neutrophil elastase (HNE) are significantly increased in both the paediatric and adult patients. This study utilized enzymatic assays that quantified the enzymatic activity in the blood circulation rather than measurement of the enzyme protein complex. Increased concentrations of MPO were, in part, related to the blood prime with the paediatric patients and the HNE concentrations were related to time on CPB in both the paediatric and adult patient. This study demonstrated that there are significantly elevated neutrophil enzyme activities in the CPB patient and underscores the pivotal role of the neutrophil in the pathophysiology of CPB.

Adult↗
PubMed1996

AIDS fraud.

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Acquired Immunodeficiency Syndrome↗
PubMed1995

Matrotrophic viviparity in the yellowtail rockfish Sebastes flavidus

A capacity for matrotrophic viviparity was established in the yellowtail rockfish Sebastes flavidus (Teleostei: Scorpaeniformes). The incorporation of radiolabel into embryos from [14C]phosphatidylcholine present in the maternal serum during gestation provided the first in vivo demonstration of matrotrophy of phospholipid for any viviparous teleost and of any nutrient for a member of the genus Sebastes. Radiolabel content increased as embryos progressed through ontogeny. Serum proteins of 170 kDa, present in vitellogenic and embryogenic females, but not in earlier stages, in immature females or in males, indicated the presence of vitellogenin in pregnant females and, thus, the potential for matrotrophic supplementation to yolk sequestered before fertilization. The retention of higher molecular mass proteins and highly phosphorylated proteins and the maintenance of total protein content in yolk during early to mid embryogenesis argue for exogenous maternal supply during gestation. As ovarian development proceeded from the oocyte through successive embryonic stages, the distribution of yolk proteins shifted from higher (67&shy;97 kDa) to lower molecular masses (<70 kDa). The results of these experimental studies corroborate data from field investigations showing that yellowtail rockfish can matrotrophically supplement embryo nutrients obtained before fertilization. Thus, yellowtail rockfish represent a teleost species positioned within the viviparity continuum and not at its extremes.

Journal Article↗