The effect of 1-(m-trifluoromethylphenyl)-2-(beta-benzoyloxyethyl)-amino- propane hydrochloride (780 SE) on serum lipids, blood glucose and liver weight was studied in 4 experimental models, and compared with that of clofibrate and tiadenol. When rats were given a daily oral dose of 25 mg/kg or 50 mg/kg of 780 SE for 5 days a marked reduction of serum triglycerides and liver weight was observed. The decreases were more pronounced than those in rats treated with 50 mg/kg or 100 mg/kg of clofibrate or tiadenol. On the other hand, a reduction of serum cholesterol was only observed in the groups given clofibrate and tiadenol. These differences could be explained on the basis of the mechanism of action of the different drugs. Only 780 SE induced a decrease in blood sugar level, a reduction of plasma insulin concentration and restored the insulin sensitivity to a normal value in obese animals. There was a significant decrease in liver weight of 780 SE treated rats, whereas clofibrate and tiadenol cause hepatomegaly.

Animals↗

PubMedDate not supplied

Detection and measurement of fetomaternal hemorrhage following diagnostic cordocentesis.

OBJECTIVE: The aim of this study was to investigate the effect of cordocentesis on fetomaternal hemorrhage (FMH). METHODS: One hundred and three diagnostic cordocenteses, without any other associated procedure, were performed at 23-40 weeks' gestation. FMH was detected using the Kleihauer-Betke staining of maternal blood taken immediately before and after cordocentesis. RESULTS: Significant FMH occurred after 40 (38.8%) of the 103 procedures. An increased risk of fetal bleeding was associated with both an anterior placenta (odds ratio (OR) 5.89; 95% confidence interval (CI) 2.27-15.3; p < 0. 001) and a transplacental cordocentesis (OR 37.0; 95% CI 2.15-636; p < 0.001). The volume of FMH was greater after cordocentesis with an anterior placenta (90th percentile 6.20 ml) than after cordocentesis with a lateral (90th percentile 4.58 ml) or posterior placenta (90th percentile 1.35 ml) (p < 0.001). After fetal blood sampling, significant FMH occurred more frequently with a procedure duration of 3 min or more (OR 4.45; 95% CI 1.70-11.7; p = 0.002) and with two or more needle insertions (OR 4.65; 95% CI 1.80-12.1; p = 0.001). CONCLUSION: FMH following cordocentesis may be related to placental injuries. This event is influenced by placental location, procedure duration and the number of needle insertions.

Cordocentesis↗

PubMedDate not supplied

[Circulating nurse in ophthalmology].

Explore the source record for details and available documents.

Eye Diseases↗

PubMedDate not supplied

[Reframing, a type of paradoxical intervention in alcoholics (author's transl)].

In their interviews with alcoholics, the authors apply a so-called "reframing", i.e. a voluntary and positive redefinition of the "pathological" behavior described by the patient. This paradoxical intervention allows a change in self-concept which makes possible the progression of a therapeutic process that would have been compromised by the "symmetrical opposition" described by Bateson as characterizing the alcoholic's relationship to his environment. Through reframing, the therapist does not oppose his patient but gives a new meaning to his experience, hence avoiding symmetrical opposition. The analysis of interviews with an alcoholic patient hospitalized at the Ruyff Psychiatric Hospital (Henri-Chapelle) illustrate the increasing opposition in the patient-therapist relationship despite a classical attitude of benevolence, contrasting with the positive modification of the patient's attitude due to the reframing process.

Adult↗