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Biomedical subjects

M Bory

Publications and source records attributed to M Bory.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

[Pulsed Doppler echography in the quantification of aortic insufficiency in adults].

Since several methods based on doppler-echocardiography have been suggested to quantify aortic valve regurgitation, we compared two of these methods--left ventricular diastolic jet mapping and evaluation of blood flow in the descending aorta--with the results of left heart catheterization in 82 patients with aortic regurgitation. The invasive quantification rested on the degree of left ventricular opacification after contrast injection into the supra-sigmoid aorta, the results being classified into 3 grades. Left ventricular mapping was carried out using pulsed doppler ultrasound by the apical route; results were expressed as 3 grades of increasing severity. Blood flow in the aorta was recorded using pulsed doppler velocimetry by the suprasternal route at the level of the aortic isthmus where we measured the diastolic to systolic velocity integrals ratio (D/S). Apical mapping could be performed in 81 of the 82 patients, whereas suprasternal planimetry could be performed in only 56 patients (68 p. 100). Mapping provided good correlations with catheterization in 65 patients (80 p. 100); discordances were observed mainly in patients with aortic leakage due to prosthetic valve dysfunction (4/8 prosthetic valves) or with major left ventricular dilatation (found in 7 out of 9 cases of underestimation of leakage by the doppler system). The D/S ratio values obtained by the suprasternal route ranged from 16 to 28 p. 100 for mild angiographic leakage, from 34 to 66 p. 100 for moderate leakage, and from 52 to 155 p. 100 for severe leakage. "Borderline" values of 30 and 60 p. 100 respectively enabled the various degrees of aortic regurgitation to be separated. Despite their limitations, the non-invasive methods used in combination are effective in quantifying aortic regurgitation in most cases; mapping offers the advantage of simplicity: the suprasternal study is more accurate but cannot be performed in all patients.

Adult↗
PubMedDate not supplied

[Peripheral neuropathy and cyclosporin. Apropos of 2 cases].

We report two cases of peripheral neuropathy arose during treatment with cyclosporine. The first observation was in a 24 year-old female treated because of a recent diabetes mellitus, the second in a 52 year-old male whose treatment was given after a cardiac transplantation. Chronology, clinical presentation and morphological findings on nerve biopsy were very close in both cases ans intrinsic imputability was stated as "possible" according to the method used to assess unexpected or toxic drug reaction by the French Regional Drug Monitoring Centers. It remains to confirm with similar reports the putative part played by cyclosporine as strongly suggested in ours.

Adult↗
PubMedDate not supplied

[Slow-release verapamil 240 mg and treatment of mild to moderate hypertension].

The study was carried out in association with medical practitioners who were responsible for observing the patients. Its aim was to determine the effective dosage of slow release verapamil (V) in the treatment of mild to moderate hypertension and to compare plasma concentrations of V with blood pressure effects. The study comprised a 2-week placebo period and a 3-month active treatment period with V, during which patients were examined, 20-24 h after last intake of V, at the end of the first (D30) and of the third (D90) month of treatment. Active treatment started with 240 mg of V (once a day); at D-30 if diastolic blood pressure (DBP) remained above 90 mmHg the dosage of V was increased to 480 mg (t.d.s.). At each examination blood pressure, body weight and heart rate were registered, electrocardiogram and routine biochemical tests were carried out; plasma concentration of V was measured at D30 for every patient and at D90 for those receiving 480 mg. of V. Thirty patients (11 men and 19 women) aged from 29 to 80 years (mean : 61.7) took part in the study. Treatment needed to be stopped in one patient; results are based on the other 29. At D30 systolic blood pressure (SBP) fell from 179.4 +/- 5.9 to 156.2 +/- 5,5 mmHg and DBP from 101.3 +/- 1.8 to 88.3 +/- 3 mmHg; DPB became normal (less than 90 mmHg) in 23 subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗