The ultrastructural localization of acid phosphatase in the crypt epithelium of the irradiated mouse duodenum.
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Acid Phosphatase↗
Biomedical subjects
M Borgers
Publications and source records attributed to M Borgers.
Beta-blockade in the ischemic reperfused working rabbit heart: dissociation of beta-adrenergic blocking and protective effects.
The cardioprotective effects of the beta-blocking drugs (dl-nebivolol, d-nebivolol, propranolol, atenolol, dilevalol and pindolol) were tested in the isolated working rabbit heart. The effects of l-nebivolol, having little beta-adrenoceptor blocking activity, were also studied. The hearts were subjected to 25 min ischemia, followed by 30 min of reperfusion. In solvent-treated hearts, ischemia resulted in a considerable loss of function. The mean functional recovery of one of the most sensitive parameters, i.e. aortic flow, was only 6%. Pretreatment either with dl-nebivolol, d-nebivolol, l-nebivolol or propranol significantly improved cardiodynamic function. Recovery after pretreatment with atenolol, dilevalol and pindolol (less than 10 mg/l) was not significantly improved when compared to solvent-treated hearts. The results suggest that the protective effects of some beta-blockers are most probably not related to beta-adrenoceptor blocking activity.
Adrenergic beta-Antagonists↗
The epidermal architecture of an in vitro reconstructed human skin equivalent (Advanced Tissue Sciences Skin2 Models ZK 1300/2000).
We investigated the epidermal ultrastructure of an organotypic skin culture model over a culture period of one week. At delivery, the stratified keratinizing epidermis consists of a basal layer with hemidesmosomes, a spinous layer with desmosomes, a granular layer with keratohyalin and membrane coating granules, a horny layer enclosing many lipid droplets. At the epidermal-dermal junction laminae lucida and densa are evident. After 7 days of culture the multilayered cornifying aspect persists; the number of viable cell layers remains constant. Spinous cells display abundant glycogen deposits. In the granular layer keratohyalin granules are more abundant. Both the size and number of hemidesmosomes increase. Anchoring fibrils are observed. From a structural point of view the model remains stable and well differentiated in culture and, therefore, may be well suited for pharmacological purposes.
Basement Membrane↗