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Biomedical subjects

M Bonnyns

Publications and source records attributed to M Bonnyns.

At least 37 records · Page 2Linked to original sources
PubMed1980

Grades of subclinical hypothyroidism in asymptomatic autoimmune thyroiditis revealed by the thyrotropin-releasing hormone test.

Serum levels of T4 T3, and TSH and peak TSH after TRH administration were determined in 60 female subjects affected with asymptomatic autoimmune thyroiditis (AAT), in 27 normal subjects, and in 8 myxoedematous patients used as controls. The AAT subjects were divided into 3 groups on the basis of their basal and peak TSH values. In the first group (grade I AAT), these parameters were similar to those of the normal controls; in the second (grade II AAT), basal TSH remained normal but peak TSH was significantly increased; and in the third (grade III AAT), both parameters were significantly increased. Serum T4 levels decreased progressively from group 1 to group 3, but all T4 values were within the normal range. T3 levels were similar in all groups. Peak and basal TSH values were highly correlated, except in grade II AAT. There seems to exist a graded process of subclinical hypothyroidism in AAT; a progressive pituitary TSH reserve is modulated by a progressive decrease in T4 levels still within the normal range.

Adult↗
PubMed1979

Circulating immune complexes in various thyroid diseases.

In a study of 171 patients with various thyroid diseases, circulating immune complexes (CIC), measured by a C1q solid phase radioassay, were detected in 26% of the patients as compared to 8% of the control subjects. CIC were found in 33--55% of the patients with a well defined thyroid autoimmune disorder (Hashimoto's goitre, asymptomatic thyroiditis, spontaneous myxoedema and Graves' disease) and also in the same proportion of patients with diffuse goitre. CIC were correlated to the presence of serum antibodies to microsomal thyroid antigen but not to their titre. No relationship was observed between CIC and the age or sex of the patients and the presence of exophthalmos, or between CIC and the different thyroid function tests or serum anti-thyroglobulin antibodies. CIC were found in untreated patients as well as in those treated with prednisone, methimazole or thyroxine.

Adolescent↗
PubMed1975

Graves' disease.

Explore the source record for details and available documents.

Affective Symptoms↗
PubMed1975

Pituitary TSH in normal subjects and in patients with asymptomatic atrophic thyroiditis: Evidence for its immunological heterogeneity.

Biological and radioimmunological measurements of pituitary TSH concentration were performed in 22 cases of asymptomatic atrophic thyroiditis and in 18 controls. Whilst bioassay revealed the presence of a greater pituitary TSH concentration in thyroiditis cases, radioimmunoassay failed to confirm such a difference. The reason therefore seems to lie in the presence in thyroiditis pituitatries of a TSH which reacted in the bioassay but showed only a weak affinity for the anti-hTSH antiserum. The slopes of radioimmunological dilution curves of the pituitary extracts were indeed significantly lower with thyroiditis pituitaries than with controls. When the whole population sample was considered, a negative correlation existed between the ratio of biological and radioimmunological TSH determinations (B/I) and the slope of the corresponding dilution curves. Since in radioimmunoassay a low displacement slope is indicative of a weak immunological affinity of the antigen for the antiserum, this demonstrated negative correlation suggests together with a high B/I ratio, even in normal people.

Biological Assay↗