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Biomedical subjects

M Bonnet

Publications and source records attributed to M Bonnet.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Clinical correlation between rubeosis iridis and optic disc neovascularization (author's transl)].

Clinical findings and fluorescein angiographies of 293 eyes affected with proliferative diabetic retinopathy were reviewed with the specific aim of looking for a possible correlation between rubeosis iridis and the localization of the new vessels in the ocular fundus. In this series there was a highly significant correlation between rubeosis iridis and optic disc new vessels. Rubeosis iridis was present in 49% of the eyes with optic disc new vessels against only 5.5% of the eyes with retinal new vessels not associated with optic disc new vessels. Among the 97 eyes affected with rubeosis iridis, 91 (93.8%) had also optic disc neovascularization. This clinical correlation allows for predicting which of the eyes affected with proliferative diabetic retinopathy are at a high risk of developing rubeosis iridis. In addition to this, this clinical correlation leads to the hypothesis that there is uveal hypoxia associated to retinal hypoxia in those eyes with rubeosis iridis. Thus iris new vessels may result from uveal hypoxia rather than from retinal hypoxia.

Diabetic Retinopathy↗
PubMed1981

[Problems posed by prenatal diagnosis of abdominal wall malformations].

The authors present 6 observations of in utero detected abdominal wall defect : 2 laparoschisis and 4 omphaloceles. In three cases the diagnosis have been done prior week 20, by systematic AFP assay for amniocentesis performed for cytogenetic or metabolic reasons; the pregnancy was terminated. In three other cases, the pregnancy was complicated by hydramnios after week 30; amniocentesis for AFP and echography were performed to detect fetal malformations after associated with hydramnios. The detected abdominal wall anomaly was not alone: two fetus had an abnormal caryotype (trisomy 18), three other presented a polymalformative syndrome, a Beckwith-Wiedemann syndrome was discussed for the last child. The in utero diagnosis of omphalocele or laparoschisis implicates difficulties for genetic counselling, particularly if the diagnosis is done prior week 20. These anomalies can be treated with surgical management, but frequency of associated malformations must be underlined. it is important for genetic counselling to know the family history, the amniotic fluid cells caryotype, and an ultrasound scanning performed to reveal any other malformations.

Abdominal Muscles↗
PubMed1981

[Acetylcholinesterase: an additional test for diagnosis of fetal malformations].

From an observation of in utero suspected myelomeningocele, the authors underline interest of pattern of cholinesterases using acrylamide gel electrophoresis. The AChE isoenzyme band appears in some fetal malformations, particularly NTD. This biochemical test is considered as complementary of the AF alpha-fetoprotein assay.

Acetylcholinesterase↗
PubMed1981

[Immunosuppressive therapy of Behcet's syndrome. Long term follow-up evaluation (author's transl)].

18 patients suffering from Behcet's disease were treated with chlorambucil. In addition 6 patients who were threatened by acute and permanent blindness received antilymphocyte globulines. The follow-up varies from 1 to 12 years with an average of 4,5 years. Recovery from ocular inflammation was total in 14 patients, and partial in 4 patients. 6 eyes underwent an uneventful cataract extraction. None of the 8 one-eyed patients became blind. The mean improvement of visual acuity at the end of the follow-up period was 0,4. However recurrences occurred in 3 patients when the treatment was stopped. In this series blood cell tolerance was the major problems encountered. The results achieved in this series lead to confirm that chlorambucil and A.L.G. have dramatically improved the ocular prognosis of Behcet's disease. However chlorambucil must not be considered to be the ultimate answer to the treatment of Behcet's disease since recurrences occur when the treatment has been stopped. In addition to this, long term treatments with chlorambucil involve a high risk of severe blood complications.

Adolescent↗
PubMed1980

Iris fluorescein angiography and Irvine Gass' syndrome.

Iris fluorescein angiography and fundus fluorescein angiography were performed three months to three years after cataract extraction in two series of aphakic eyes--32 eyes with vitreous adherence to the wound, and 32 with no vitreous adherence to the wound. In these series there is a significant correlation between dye leakage on iris fluorescein angiography and vitreous adherence to the corneal wound since dye leakage was observed in 40.6% of eyes with vitreous adherence to the wound and only 3.1% of eyes with no vitreous adherence to the corneal wound. On the other hand cystoïd macular edema was observed in 100% of eyes with vitreous adherence to the wound associated with dye leakage on iris fluorescein angiography and in only 10% of eyes with vitreous adherence to the wound but no dye leakage on iris fluorescein angiography.

Aphakia, Postcataract↗