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Biomedical subjects

M Boada

Publications and source records attributed to M Boada.

42 records · Page 3Linked to original sources
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[Neuropsychiatric inventory questionnaire (NPI-Q): Spanish validation of an abridged form of the Neuropsychiatric Inventory (NPI)].

BACKGROUND: The Neuropsychiatric Inventory (NPI) is a validated clinical instrument for the evaluation of psychopathology in dementia. OBJECTIVE: To validate a brief questionnaire form of the NPI (NPI-Q) in Spanish from NPI-Q original version, intended for use in routine clinical practice. PATIENTS AND METHOD: We have developed a crossed validated form between NPI and NPI-Q in 120 Alzheimer's disease patients. RESULTS: Test-retest reliability of the NPI-Q, using Pearson correlation index was r = 0.89 for total symptom scale and r = 0.90 for distress scale. The prevalence of analogous symptom ratings differed by less than 6.7%. Convergent validity between NPI-Q and NPI, using Pearson correlation index was r = 0.879 for total symptom and r = 0.92 for distress scale. CONCLUSIONS: The NPI-Q Spanish version offers the possibility to use a reliable and brief instrument that can be used as a screening in the evaluation of neuropsychiatric symptoms in dementia and associated caregiver distress. It may be suitable for use in general clinical practice and it could be used as a brief neuropsychiatric interview.

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[Behavioral pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD): Spanish validation].

INTRODUCTION: The Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD) is a screening instrument for the evaluation of behavioral disturbances in Alzheimer's patients. Our aim was to validate the BEHAVE-AD test in Spanish, intended for use in routine clinical practice. METHOD: We assessed the validity of the BEHAVEAD in 79 nursing-home patients with diagnosis criteria of dementia, scoring 4 or higher on the Global Deterioration Scale (GDS) scale, by developing a crossed validated form between the Neuropsychiatric Inventory-Questionnaire (NPI-Q) and BEHAVE-AD tests. Both instruments were rated by an expert clinician. In order to study the concurrent validity of some of the BEHAVE-AD subscales, we compared the Cohen-Mansfield Agitation Inventory (CMAI) and the Hamilton Depression Rating Scale (HDRS) tests. RESULTS: The Pearson correlation index between the BEHAVE-AD test and the NPI-Q, was significant but moderate (r=0.694). Pearson's correlation between BEHAVEAD's symptoms scale and NPI-Q's severity scale was r=0.698. When comparing BEHAVE-AD's global evaluation scale (caregiver's disturbance) and NPI-Q's distress scale, the correlation index was 0.535. CONCLUSIONS: The BEHAVE-AD Spanish version offers the possibility to use a screening tool for the detection of neuropsychiatric symptoms in dementia patients, also applicable to nursing home residents, administered by an expert clinician.

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[Epidemiology of cognitive deterioration in geriatric population of 'Casals d' Avis' in the city of Barcelona].

The aim of the study is to carry out a clinico-epidemiological study of the part of Barcelona's population over the age of 65 that suffers from cognitive deterioration, users of 'Casal d'Avis' (Old-folks centres). 369 users of 'Casals d'Avis' were studied. A specific questionnaire was used to collect the following data: personal details, social and family situation, health profile and a quantification of their degree of cognitive degeneration using Lobo's cognitive test. The quantitative and qualitative variables were studied statistically, and the arithmetical average and standard deviation were found, as well as which bivariant hypothesis tests and multivariant analyses, using the logistic regression method, were carried out. The degree of cognitive deterioration is 8.67%. Age, female sex, being widowed or single, and illiteracy are associated with low scoring in the MEC. It is also associated with subjective loss of memory and hearing difficulties. The multivariant analyses are influenced by length of schooling, age and sex. Early detection of cognitive deterioration and the supply of resources and services oriented towards cognitive stimulation and social integration would, if well-planned, do away with the need for their confinement.

Age Factors↗
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[Epidemiology of cognitive deterioration in the institutionalized geriatric population of the socio-sanitary centers in the city of Barcelona].

The aim of the study is to carry out a clinico-epidemiological study of the part of Barcelona's in-patients of 'Health-centers/Nursing-homes' elderly people that suffers from cognitive deterioration. 363 in-patients of 'Health-centers/Nursing homes' were studied. A specific questionnaire was used to collect the following data: Personal details, social and family situation, health profile and quantification of their degree of cognitive deterioration using Lobo's cognitive test. The quantitative and qualitative variables were studied statistically, and the arithmetical average and standard deviation were found, as well as which bivariant hypothesis tests and multivariant analyses, using the logistic regression method, were carried out. Adjusted degree of cognitive deterioration was 56%. The age, the fact that the patients were female, illiteracy and working as house-wives all made for low MEC ratings. Variables such as health, subjective memory loss, the presence of cerebral vascular pathology an hypercholesterolemia behaved in a similar fashion. Age, female sex, illiteracy and being a house-wife are associated with low scoring in the cognitive test, as well as subjective loss of memory, cerebral vascular pathology and hypercholesterolemia. The multivariant analyses are affected by: age and length of schooling. Were the in-patient group is concerned, functional remodelling of specific areas is indicated, and who have to be taken into care as a result of the seriousness of deterioration their dependence and their need for assistance.

Age Factors↗
PubMedDate not supplied

[Pre-implantation genetic diagnosis: indications, techniques, and results].

The combination of the technique of In Vitro Fertilization (IVF) and molecular genetics has led to the development of Preimplantation Genetic Diagnosis (PGD). Oocyte and embryo biopsy, Fluorescent in situ Hybridization (FISH) and Polymerase Chain Reaction (PCR) allow diagnostic procedures in couples with high risk and also certain IVF couples. We present a review of PGD indications, techniques and results.

Biopsy↗