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Biomedical subjects

M Blichert-Toft

Publications and source records attributed to M Blichert-Toft.

At least 145 records · Page 8Linked to original sources
PubMed1984

Spontaneous pituitary-thyroid function after surgical treatment of nontoxic goitre. A controlled long-term study.

The free thyroxine index (FT4I), triiodothyronine (T3) and thyroid stimulating hormone (TSH) in serum and the peak serum TSH (TRH test) were measured in 18 patients with nontoxic uninodular goitre and 32 patients with nontoxic multinodular goitre before and 3, 6, 12, 24 and 36 months after goitre resection. Thyroid hormone therapy was not given postoperatively. Resection of non-toxic goitre provoked a transient rise in TSH baseline level, with peak about one year after surgery. Three years after the resection the TSH baseline had returned to the preoperative level. The TSH changes were significantly more pronounced in the multinodular goitrous group, in which resection was bilateral, than in the uninodular goitrous group. The changes in serum FT4I and serum T3 were of moderate degree and most pronounced in the multinodular group. During long-term observation, serum FT4I increased slightly but significantly in both groups, but serum T3 showed significant reduction, albeit within reference range. The results of the study suggest that thyroid hormone therapy as a routine procedure after simple goitre resection lacks a tenable rational basis.

Adult↗
PubMed1984

Breast conserving therapy for mammary carcinoma. An experimental procedure or a genuine alternative to mastectomy.

Interest in breast-conserving treatment of mammary carcinoma has increased tremendously in recent years, as breast cancer is being detected at an earlier stage than previously, especially in regions where screening is practised. In the present report it is argued that the breast-conserving procedure is still an experimental method which should be performed only within the framework of clinically controlled studies. An uncritical use of the method could render its improvement difficult and prevent an accurate assessment of its possibilities for cure. A short description is given of a recently started Danish multicentric study in which the result of breast-conserving therapy, randomly, is weighed against the result of mastectomy. The preliminary experience of the method obtained in the Odense Centre is submitted. Since 1979 a total of 44 patients have had breast-conserving therapy for mammary carcinoma. Their median age was 47 years, range 30-69 years. About 10% had stage II cancer. So far, local recurrences in the breast have not been observed within the follow-up period, 5-48 months, but one case of axillary recurrence. Metastatic disease has not been demonstrated.

Adult↗
PubMed1984

Long-term study of serum calcium changes following goitre resection.

Levels of corrected serum calcium, serum free thyroxine index, and serum thyroid stimulating hormone were measured prior to thyroid surgery and 3, 6, 12, 24, and 36 months postoperatively in 18 patients with nontoxic uninodular goitre and in 32 patients with nontoxic multinodular goitre. Additionally, the corrected serum calcium was also determined on the fourth day of surgery. In the former group unilateral resection was done, whilst the latter group had bilateral resection of the thyroid gland. In both goitrous groups, the study demonstrated a slight lowering, albeit significant, of the corrected serum calcium level postoperatively. However, during the study period the mean level of serum calcium was within reference range. Remarkably, there was no significant difference as to change in calcium levels between the two surgical groups. The calcium disturbances were not related to postsurgical thyroid function. Other possible explanations to the change in serum calcium level are discussed, but no responsible mechanism was clarified in the study. It is concluded that although a significant lowering of serum calcium levels takes place after goitre resection, the changes seem not to indicate any therapeutic measures in the long run.

Calcium↗
PubMed1983

Identification and functional recording of the recurrent nerve by electrical stimulation during neck surgery.

A method for identification and functional recording of the recurrent nerve during neck operations is described. The basic principle implicates electrical stimulation of the recurrent nerve causing adduction of the vocal cord registered by means of a balloon placed between the vocal cords. Three different recording methods have been tested in animal experiments and during 26 neck operations on patients. The most simple method employed is recommended as a routine procedure, likely to reduce surgical damage to the recurrent nerve.

Animals↗
PubMed1983

Influence of adjuvant irradiation on shoulder joint function after mastectomy for breast carcinoma.

The influence of postoperative radiation therapy on ipsilateral shoulder function following mastectomy was evaluated from a series of 52 women with primarily operable carcinoma of the breast. Mastectomy and partial axillary dissection were carried out in all patients. In addition, 29 of the patients received postoperative irradiation with 36.6 Gy applied mid-axillarily in 12 fractions with irradiation twice a week. A significant impairment of the active shoulder mobility was found in the irradiated group (p less than 0.01). The passive mobility did not differ significantly between the two groups. The impairment of active shoulder mobility is suggested to be caused by radiation induced subcutaneous fibrosis.

Adult↗