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M Blanchette

Publications and source records attributed to M Blanchette.

21 records · Page 2Linked to original sources
PubMed1981

Serous otitis media: a six week prospective study.

The purpose of this project was to attempt to outline the natural history of serous otitis media. Sixty-eight children with uni or bilateral serous otitis media were placed under observation for a six week period. They were all left untreated. Otoscopy, impedance, and audiogram measurements were used to monitor the evolution of the disease. Results showed that spontaneous resolution occurred in 35 per cent of cases. Girls were cured more frequently than boys. Furthermore, the disease receded more satisfactorily in the right than in the left ear. Within our group of patients, age was not a factor in the evolution of the otitis. Finally, the impedancometry and audiometry were not useful in assessing the probable evolution of this disease.

Acoustic Impedance Tests↗
PubMedDate not supplied

Phylogenetic invariants for genome rearrangements.

We review the combinatorial optimization problems in calculating edit distances between genomes and phylogenetic inference based on minimizing gene order changes. With a view to avoiding the computational cost and the "long branches attract" artifact of some tree-building methods, we explore the probabilization of genome rearrangement models prior to developing a methodology based on branch-length invariants. We characterize probabilistically the evolution of the structure of the gene adjacency set for reversals on unsigned circular genomes and, using a nontrivial recurrence relation, reversals on signed genomes. Concepts from the theory of invariants developed for the phylogenetics of homologous gene sequences can be used to derive a complete set of linear invariants for unsigned reversals, as well as for a mixed rearrangement model for signed genomes, though not for pure transposition or pure signed reversal models. The invariants are based on an extended Jukes-Cantor semigroup. We illustrate the use of these invariants to relate mitochondrial genomes from a number of invertebrate animals.

Algorithms↗