Ashy dermatosis associated with cobalt allergy.
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Adult↗
Biomedical subjects
M Bisceglia
Publications and source records attributed to M Bisceglia.
[Primary splenic cysts. Report of 5 cases, 4 of which unpublished and review of the literature].
After a complete review of the literature with an amount of 280 previously reported cases, the authors report on five total cases of primary (true) cysts of the spleen one of which already published. All these cases occurred in pediatric age and were treated by total splenectomy. All were large solitary cysts (size ranged from 4.5 up to 15 cm) but one, the largest of which in addition to the main cavity exhibited some more microscopic cysts of the same type few mm sized. Three of them were lined on their inner surface by a multilayered squamous epithelium, which in one case was also keratinized. The other two cysts showed a single layered epithelium which appeared flattened in one case, cubic in the other one. The discussion concerns the pathogenetic mechanisms which can lead to cyst formation, the imaging diagnosis of these rare lesions prior to surgical intervention, their treatment, and the correct histological recognition of these true cysts versus secondary (false) cysts or pseudocysts which commonly occur following trauma. One of the cases herein presented qualifies as a "pseudo-pseudocysts" due to the fact that a history of trauma was on record and to the fact that almost the entire epithelium was mechanically lost due to hemorrhage which filled the cyst cavity.
Adolescent↗
[Treatment of primary hepatocarcinoma with chemoembolization and alcohol injection. Personal experience].
The comparative efficacy of transcatheter arterial chemoembolization and percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC) was investigated in a series of 243 consecutive patients: 146 of them were submitted to 1-6 chemoembolization sessions at 1 and 3 months' intervals and 30 to PEI; the remaining 67 patients refused any treatment. The follow-up ranged 3 to 36 months. Survival rates were statistically analyzed with the life table analysis. Patients' survival was affected by the number of nodules and by Child's and Okuda's classes; no relationship was found between survival rates and histologic grade or nodule vascular feeding. In case of single lesions, chemoembolization was more effective than PEI in Okuda's class I. In case of multifocal HCC, chemoembolization was better than no treatment in Okuda's class I and Child's class A. In conclusion, we suggest chemoembolization as the treatment of choice in Child A or Okuda I patients with multifocal HCCs, while its use seems of little help in Child B-C or Okuda II-III patients. In case of unifocal HCC, PEI or surgical resection should be combined with chemoembolization.
Adult↗
Does a single granuloma warrant a diagnosis of idiopathic granulomatous gastritis?
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Aged↗
Hypertrophic amalgam dermatitis of the tongue simulating carcinoma.
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Aged↗
A histologic and flow cytometric study of Kaposi's sarcoma.
One hundred forty-three biopsies of Kaposi's sarcoma (KS) from 96 patients were assessed histopathologically, and mitoses were counted. Ninety-seven samples from 66 patients were analyzed by flow cytometry. Six of 97 (5.8%) KS lesions were DNA aneuploid with a clustering around a DNA index of 1.5 (range, 1.4 to 1.6). The median percentage of S-phase plus G2-phase cells (%S + G2) was 16.7%. Increasing mitotic counts and %S + G2 were seen with progression of the phase and pattern of disease. Nodular KS and spindle cell predominant KS had the highest mitotic counts and %S + G2, with nodular KS larger than 4 mm having a higher mitotic count than those smaller than 4 mm. These findings suggest a low level of DNA aneuploidy in KS and important changes in the level of cell proliferation with the phase and pattern of the disease. However, flow cytometry does not solve the dilemma of whether KS is a hyperplastic or neoplastic process.
Aged↗
Argyrophil-negative G-cell duodenal carcinoid.
A case of mono-hormonal-producing and functionally active G-cell carcinoid tumor of the duodenum is described. The tumor, found to be argyrophil negative, was investigated immunohistochemically and ultrastructurally. We report our results, then discuss the possible histochemical causes that can lead to the failure of argyrophilia, and direct attention to the possible misdiagnosis that can result from that failure.
Carcinoid Tumor↗
Kaposi's sarcoma: a clinico-pathologic overview.
A careful overview of the classical appearances of Kaposi's sarcoma (KS) as well as of its variants were reviewed from the clinical and pathological point of view. The growth phases (stages) and the cellular patterns were histopathologically compared with emphasis on the developmental progression of disease as well as mitotic activity. Other morphological aspects were also assessed such as the features of the early phases and the incidence of hyaline bodies. One hundred and forty-three lesions from 96 patients mostly of the Italian sporadic type were investigated. A complete list of those entities which should be considered in differential diagnosis is shown and the dilemma of whether KS is a neoplasia or a hyperplasia is discussed.
Adolescent↗
Muir-Torre syndrome: a case report.
The authors present a case of Muir-Torre syndrome, the "sporadic" form, with a review of the literature. The importance of the close scrutiny of these patients and their relatives is stressed.
Abdominal Neoplasms↗
Calcification of the ligamentum arteriosum in children: a normal finding on CT.
Calcification of the ligamentum arteriosum is a rare finding on plain radiographs. We commonly have seen the calcification on unenhanced CT scans of the chest, a finding not previously reported. A retrospective review of unenhanced CT scans of the chest was undertaken to determine the frequency of the described finding. Seven (13%) of 53 patients had a well-demarcated focus of calcification in the region of the ligamentum arteriosum. None of these patients had evidence of a patent ductus arteriosum. Calcification within the ligamentum arteriosum was seen in 13% of routine CT examinations of the chest in children and should not be confused with a pathologic process producing mediastinal calcifications.
Adolescent↗
Cutaneous presentation of acute myeloid leukemia in a "classical" Kaposi's sarcoma patient.
A case of early cutaneous involvement by an acute myeloid leukemia in a Caucasian man, previously affected by a "classical" Kaposi's sarcoma is reported. The diagnoses were based upon histologic examinations and appropriate hematologic investigations. After reviewing extensively the literature about the association of lymphoreticular system malignancies and Kaposi's sarcoma, possible implications and hypothetical etiopathogenetic mechanisms are discussed.
Humans↗
Mucoepidermoid carcinoma of the larynx.
Two cases of mucoepidermoid carcinoma (MEC) of the larynx are reported. The peculiarities of both cases are emphasized, in particular the site of involvement and the young age of the former and the histological subtype ("clear cell" variant) of the latter. The microscopic differential diagnosis of MEC and its biological behavior according to the grade of differentiation is discussed. The available literature is reviewed.
Adult↗
The pump maneuver: an atraumatic adjunct to enhance US needle tip localization.
Real-time ultrasound (US)-guided biopsies and drainage procedures require constant visualization of the needle tip. Ensuring optimum needle tip visualization is paramount to the success of these procedures. The authors have found that pumping the stylet in and out of a stationary needle shaft increases the echo-genicity of the needle shaft and tip, thereby facilitating needle localization. This technique, which we have termed "the pump maneuver," is a quick, useful, and atraumatic adjunct to be considered during US-guided percutaneous needle biopsy and drainage procedures.
Biopsy, Needle↗
Renal oncocytoma: a clinicopathologic study of a case with review of the literature.
A peculiar case of renal oncocytoma was studied by clinical, light- and electron-microscopic examinations. The neoplasm, which was first discovered 21 years ago, at operation turned out to be very large, well-circumscribed and lacking any feature of aggressiveness. Histologically, it was composed totally of oncocytes without relevant atypia or necrosis. Ultrastructurally, a cytoplasmic filling by mitochondria with paucity of other organelles and filaments also supported the diagnosis. The authors also reviewed the literature and emphasized the diagnostic criteria of this type of tumor.
Adenoma↗
Leukocytoclastic vasculitis of the colon.
Two cases of young patients with an acute abdomen caused by a necrotizing angiitis of the cecum and ascending colon are reported. The absence of any systemic disease and a history of medical treatment in both cases led to the diagnosis of hypersensitivity vasculitis by a serum sickness-like reaction. An extensive review of the literature is also presented.
Adolescent↗
Primary Kaposi's sarcoma of the lymph node in children.
A case of primary Kaposi's sarcoma of the lymph node (single node involvement) is reported on here. It occurred in a white, Italian boy 10 years of age. An extensive review of the literature showed that this was only the second childhood case of the disease among non-acquired immune deficiency syndrome (AIDS)-related people of the Western world.
Child↗
Granular cell tumor of the esophagus.
Granular cell tumor (GCT) of the esophagus is a rarely-met-with neoplasm. It is almost invariably benign in character and is of still-disputed histogenesis. Small lesions are asymptomatic. Those over 1 cm in diameter may be accompanied by painful swallowing or retrosternal discomfort. Local resection is the treatment of choice for lesions that are accompanied by symptoms, or that are larger than 1 cm. A tumor incidentally encountered in an asymptomatic patient may be safely followed endoscopically. A successful endoscopic removal of such a lesion is described.
Adult↗
Metaplastic breast carcinoma with epithelial phenotype of pseudosarcomatous components.
A case of metaplastic breast carcinoma was subjected to an immunohistochemical study to characterize its apparent fibrosarcomatous and chondrosarcomatous elements. Polyclonal and monoclonal antibodies against epithelial cell components such as keratin proteins, epithelial membrane antigen, membrane and cytoplasmic antigens of human mammary carcinoma cells, and carcinoembryonic antigen were used, as well as antibodies against the mesenchymal antigens, desmin, and vimentin. The cells with a mesenchymal appearance had an epithelial derivation, as shown by the presence of epithelial cell markers and absence of mesenchymal cell markers.
Breast Neoplasms↗