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Biomedical subjects

M Binaghi

Publications and source records attributed to M Binaghi.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Ocular sequelae and sicca syndrome following Lyell's syndrome].

The mucous lesions are customary in toxic epidermal necrolysis. The acute ocular lesions have led to definitive sequelae. 22 out of 32 patients surviving to a Lyell's syndrome lend themselves to an ophthalmological supervision. 13 of these 22 patients (59 p. 100) presented a sicca syndrome with a decrease of the lacrimal secretion (12 cases) and/or salivary secretion (8 cases). The sicca syndrome appeared sometimes from the beginning of the acute phase of the Lyell's syndrome or more often a few weeks later. This decrease of the lacrimal flux went along with objective corneal lesions among 11 patients, and 6 of them had a change of the visual function. A biopsy of the accessory salivary glands was performed on 7 of these patients having a reduction of the salivary flux. 5 of these 7 biopsies showed lymphocytic infiltrates giving in 2 cases a nodular aspect, grade III of Chisholm's classification, held to be pathognomonic of Sjögren syndrome. The 13 patients having presented a sicca syndrome differed from the other 9 patients (without sicca syndrome) by a higher severity of their Lyell's syndrome and by a higher age. None of our patients with dry syndrome had antinuclear antibody detected by immunofluorescence on sections of rat's livers. Sicca syndromes with sometimes lymphocytic infiltrate similar to those of Sjögren's syndrome were occasionally imputed to drug reactions. The occurrence of "Sjögren like's syndrome" after a toxic epidermal necrolysis suggests the intervening of autoimmune phenomena in the pathogenesis of this toxic epidermal necrolysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Hypereosinophilic syndrome with ocular involvement].

The authors report a case of idiopathic hypereosinophilia with Löffler endocarditis in a 19 year old male. Retinal arteriolar occlusions were observed in the pre-equatorial region and documented by angiography. Histologic examination of the globes showed obliteration of the arterioles by a fibrinous coagulum without signs of vasculitis. Clinical data appears to suggest an embolic origin of the occlusions rather than thrombosis in situ.

Adult↗
PubMed1985

[Ocular complications of Lyell's syndrome: recent concepts apropos of 26 cases].

Acute ocular lesions are usual during Toxic Epidermal Necrolysis (T.E.N.) and may induce persistent alterations. These were thought to be of cicatricial nature. 26 patients recovering from TEN had a systematic ophthalmological follow-up of at least six months after the acute stage (mean: 3 years). 11 of 26 patients (42%) exhibited a dry eye, associated in 7 with decreased salivary flow. The sicca syndrome appeared during the acute phase of TEN or, more often, a few weeks later. The reduction of the lacrymal flow induced corneal lesions in all 11 patients and 6 patients suffered permanent visual impairment. Biopsies of labial accessory salivary glands showed a lymphocytic infiltration of the glandular tissue in 5 of 7 cases. In 2 cases the lymphocytic infiltrate was nodular, grade III of Chisholm's classification, considered as pathognomonic of Sjogren's syndrome. The occurrence of Sjogren-like syndrome in patients recovering from TEN suggests an auto-immune pathogenesis for TEN, and is one more analogy between TEN and graft-versus-host disease.

Conjunctival Diseases↗
PubMed1984

[Fluorescein angiography in the diagnosis of periarteritis nodosa].

Periarteritis Nodosa (P.A.N.) is a systemic connective tissue disease with a variety of manifestations that includes ocular involvement in 20% of cases. The diagnosis of this condition is difficult due to the absence of any specific clinical signs or laboratory findings. However, histologic studies have demonstrated a segmental vasculitis that is often necrotic. Ocular findings frequently include choroidal involvement that is characteristic. Nevertheless, angiographic studies of this disease are extremely rare. The findings in three patients suspected of having P.A.N. are presented. Fluorescein angiography established the diagnosis of P.A.N. in two cases and ruled-out its presence in the third case. In the first case angiography demonstrated a retinal vasculitis with multiple arteriolar and capillary occlusions. There was also ischemic involvement of the choriocapillaris and a mild anterior optic nerve vasculitis. All findings resolved, leaving numerous Elschnig spots. In the second case the angiogram showed acute multifocal ischemia of the choriocapillaris. The ocular examination and fluorescein angiogram in the third case were entirely normal, thereby ruling-out P.A.N. on the basis of insufficient criteria. Acute multifocal choroidal ischemia is present in a variety of rare conditions: Toxemia of pregnancy, Disseminated Intravascular coagulopathy, Moskowitz Disease (T.T.P.), Leukemia and Malignant Hypertension. However, the presence of multifocal choroidal ischemia in the presence of a systemic connective tissue disorder strongly favors the diagnosis of P.A.N. The relative contributions of co-existent Malignant Hypertension and P.A.N. in producing choroidal ischemia are discussed. The spectrum of clinical manifestations and laboratory findings in P.A.N. as well as hypotheses concerning pathogenesis (immune-complex deposition) are described. Among all systemic vasculitis , only P.A.N., and rarely Scleroderma, feature choroidal involvement. This is possibly due to the fact that the degree of vasculitis in P.A.N. is sufficiently severe to cause clinically significant choroidal involvement.

Adult↗
PubMed1984

[Effects of red krypton and monochromatic green argon lasers in the foveal region. A clinical and experimental study].

The destruction of senile neovascular membranes in the central avascular region of the macula using argon laser is difficult and associated with complications. Yellow pigment in this region absorbs the blue component of the conventional argon laser radiation. In this study, we compared laser of different wavelenghts: red krypton and green argon. Light and electron microscopic studies on non-human primates were performed at one hour and three weeks following laser burns. With the red krypton laser maximum damage was seen at the level of choriocapillaris and the choroïd, although the pigment epithelium was also destroyed. With the green argon laser the maximum absorption occurred at the level of the pigment epithelium. A clinical and angiographic study showed that the destruction of juxtafoveal neovascular membranes by both these lasers was possible after one or several treatment sessions. After an average follow-up period of 45 months, visual acuity was stable or improved in 10 out 17 eyes treated with the green argon laser and in 27 out of 53 eyes treated with the red krypton laser. Our results suggest that the red krypton laser offers a better alternative for the treatment of neovascular membranes located near the foveola since less unnecessary damage is induced. Outside the xanthophyllic area there is no major difference between the different wavelengths.

Animals↗
PubMed1984

[Hydration of the animal cornea: spectrometric study using proton nuclear magnetic resonance].

The concentration of water in isolated corneas was studied using a Nuclear Magnetic Resonance Protonic (P N M R) technique. The corneas were maintained in moist chambers or in different aqueous fluids in order to compare the results obtained by. P N M R with those provided by classical techniques. The magnetization ratio, associated to water component measured as a function of corneal conservation time has permitted to establish the corneal water content variation. The corneas preserved in moist chamber exhibited a slow dehydration of about 15% in the first day. On the contrary, hydration was evident in liquid media, the strongest in pure water. No significant differences were found between saline, T C Earle medium and Neomycin ophthalmic suspension. P N M R technique give an index of corneal hydration in these conditions and it seems possible to use a P N M R apparatus for the evaluation of a corneal graft before surgery.

Animals↗
PubMed1983

Birdshot retinochoroidopathy and subretinal new vessels.

Decrease of visual acuity in birdshot retinochoroidopathy is due either to optic atrophy or to 3 types of macular involvement: cystoid macular oedema, geographic atrophy, or macular serous detachment. We describe 3 cases of juxtapapillary subretinal neovascularisation occurring in long-standing birdshot retinochoroidopathy. The mechanism of the formation of the new vessels is discussed.

Adult↗
PubMed1983

[Thrombotic microangiopathy and its ocular manifestations: an unusual complication of bone marrow graft].

The clinico-pathological aspect of an unusual case of thrombotic microangiopathy (M.A.T.) is reported in acute leukemia one year after bone marrow graft. The patient was first seen complaining of blurred vision in both eyes. Ocular findings included choriocapillaris and retinal vascular occlusions, resulting in bullous retinal detachments, massive retinal exudation and cystoid macular edema. The relationship between M.A.T. and bone marrow grafting is discussed with respect to the immunological disorders or graft-versus-host reaction and the role of irradiation.

Adult↗
PubMed1983

[Retinal phacomas. Apropos of 10 cases of astrocytoma].

Clinical and angiographic findings in 10 cases of retinal astrocytomas seen at the Clinique Ophtalmologique de Créteil are described. Classical features concerning onset of the disease, clinical aspects, and evolution of these tumors are confirmed. Some atypical findings are reported, including the marked proportion of isolated astrocytomas unrelated to phacomatosis, and the high frequency of complications of these lesions, usually considered to be stable.

Adolescent↗
PubMed1983

[Diffuse retinal epitheliopathy and central serous chorioretinopathy].

Follow-up examinations were conducted in 27 patients (51 eyes) affected by diffuse retinal pigment epitheliopathy (D.R.P.E.), over an average period of 37 months. This disease associates multiple subretinal foci of leakage resulting in retinal serous detachments (R.S.D.), often widespread alterations in retinal pigment epithelium, and frequent small serous detachments of retinal pigment epithelium. The course is chronic and recurrence of subretinal leakage is common. Involvement of macular pigment results in poor long-term visual prognosis. Features of these patients were compared with those of 138 patients affected by central serous choroidopathy (C.S.C.). Both D.R.E.P. and C.S.C. are more frequent in males, and demonstrate subretinal leakages and transient retinal serous detachments. Nevertheless, numerous data differentiate these two diseases, D.R.P.E. being detected at a later age (49 years) than C.S.C. (39 years). Bilaterality of the affection is more frequent in D.R.E.P. (88 p. cent) while serous detachment is less frequent in D.R.P.E. (31 p. cent) than in C.S.C. (82 p. cent). Small foci of subretinal leakage are present in both diseases but they are frequently multiple, scattered, extra-macular and mainly peripapillary in D.R.P.E.; they are chronic or recurrent and are present usually in an area of pigment epithelium depigmentation. These changes are often vertically oriented downwards towards the inferior periphery of the fundus. In D.R.P.E. there are frequently visual fields defects (70,5 p. cent) corresponding to the area of pigmentary involvement, dyschromatopsy (64 p. cent) and E.O.G. abnormalities (75 p. cent). D.R.P.E. and C.S.C. are two closely related diseases but they differ by the extent and diversity of the pigment epithelium lesions functional impairment, and visual prognosis. Photocoagulation of leaking spots resulting in macular detachment appears to be justified as in C.S.C. Long-term prognosis depends on the degree of extension of pigmentary changes into the macular area.

Adult↗
PubMed1982

A hypereosinophilic syndrome with retinal arteritis and tuberculosis.

A 35-year-old man was initially seen with a decrease in visual acuity, renal insufficiency, and elevation of the eosinophil count in the blood. The ocular syndrome was caused by extensive arterial occlusions of the retina. The subsequent apparition of cardiac, pulmonary, and neurologic signs fulfilled the criteria for the diagnosis of hypereosinophilic syndrome (HES). Most symptoms, including ocular, were temporarily but notably improved by hydroxyurea. The patient died after two years. An autopsy showed an endomyocardial fibrosis and disclosed destruction of the left kidney by an active tuberculosis. A pathogenic relationship between the infectious disease and the HES is envisaged.

Adult↗