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Biomedical subjects

M Bianchi

Publications and source records attributed to M Bianchi.

478 records · Page 27Linked to original sources
PubMedDate not supplied

Peripherally administered benzodiazepines increase morphine-induced analgesia in the rat. Effect of RO 15-3505 and FG 7142.

The influence of alprazolam, chlordiazepoxide and midazolam on the antinociceptive effect of subcutaneous morphine was investigated in rats, using the tail-flick test. After intraperitoneal administration, all drugs significantly enhanced the morphine-induced analgesia. Both the benzodiazepine receptor antagonist RO 15-3505 and the benzodiazepine receptor inverse agonist FG 7142 antagonized the potentiating effect of alprazolam, chlordiazepoxide and midazolam. Our results suggest that the interaction between benzodiazepines and opioids in modulating nociceptive responses involves primarily benzodiazepine receptors and that different pathways are involved in the anxiolytic and pro-analgesic actions of benzodiazepines.

Animals↗
PubMedDate not supplied

[Screening of urologic pathology in newborns with prenatal and postnatal echography].

We compared the results, by prenatal ultrasonography, effected on 2592 foetus at the 15th-25th-35th weeks of gestation with the ones, made by postnatal ultrasonography, effected the 5th day of life on 2539 infants born from pregnancies previously monitored. We considered the obstructive and not obstructive malformations. The prenatal ultrasonography put in evidence 19 cases of urological pathology, which is 0.75%. The postnatal research established the truth of 14 cases, which is 0.55%; 7 cases underwent a precocious surgical operation. Percentage of positive false is 0.2%. The postnatal ultrasonography made evident 30 cases which can be considered pathological: 25 uropathy obstructive cases and 5 uropathy not-obstructive cases; 3 of them underwent precocious surgical operation. The result is 44 pathological cases (1.74% of infants). We also considered an heterogeneous group of non-nephro-urological anomalies (0.47%), a casual medical report of this research; in particular, 10 cases of surrenal hematoma and 1 case of neuroblastoma. The Authors remark that it's useful to complete the prenatal ultrasonographic research with another postnatal ultrasonographic research, particularly in the nephro-urological pathology; and they hope this system can be much more diffuse.

Female↗
PubMedDate not supplied

Preoperative serum intercellular adhesion molecule-1 (ICAM-1) and E-selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) in patients with epithelial ovarian cancer.

The serum levels of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) were retrospectively measured in serum samples drawn at diagnosis from 66 patients with epithelial ovarian cancer and 128 patients with benign ovarian masses. The preoperative serum ICAM-1 levels were higher in the former group (p < 0.0001), while serum E-Selectin concentrations were similar in the two groups (p = NS). Among patients with epithelial ovarian cancer, neither serum ICAM-1 nor E-selectin levels correlated with FIGO stage and with histologic type. The serum assay of ICAM-1 and E-Selectin seems to have limited value in the management of patients with epithelial ovarian cancer.

Adult↗
PubMedDate not supplied

[Urachal cyst. A case report and review of the literature].

The pathology of urachal disease is rarely seen. This article refers to a case of urachal cyst in a twenty-five-year-old male. In order to discuss the pathogenic, clinical and therapeutic aspects of this rare pathology, it is necessary to carry out a complete revision of the literature. Diagnosis is helped by ultrasound and CT scan of the lower abdomen, while fistulography is necessary when there is cutaneous drainage. The treatment consists of surgical approach which includes complete en-bloc excision of the cyst together with possible urachal residue. Such treatment is indispensable in order to avoid acute infection and/or malignant degeneration, frequent complications which are very serious.

Adult↗