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Biomedical subjects

M Beskid

Publications and source records attributed to M Beskid.

95 records · Page 6Linked to original sources
PubMedDate not supplied

The effect of quinolinic acid administered during pregnancy on the hippocampal formation of rat's offspring (ultrastructural investigation).

The pyramidal cells of CA1 hippocampal area of rat's offspring was ultrastructurally examined after quinolinic acid administration to mothers during the gestational period, in order to mimic the congenital metabolic disturbances resulting from an endogenous excess of quinolinic acid within foetal tissues. Hence, quinolinic acid was administered to mothers intraperitoneally in a dose of 60 mmol, once daily, throughout the entire gestation period. Brain specimens were taken on Day 5 after birth, from experimental and control animals. The only observed change within the pyramidal cells was swelling of both neuronal somata and dendrites, as well as a distinct swelling of astroglia cytoplasm and processes. Besides this, toxic effects, like edema signs, were observed. Neurons of the hippocampal formation were found to be particularly susceptible to quinolinic acid toxicity. The highly vulnerable neurons were located within the CA1-area. The neuronal vulnerability correlates remarkably well with those responding to the excitatory effects of quinolinic acid in electrophysiological experiments (Perkins and Stone 1983 a,b). This region was shown to be rich in NMDA receptors (Cotman et al. 1987; Greenamyre et al. 1984). The susceptibility of neuronal cell bodies of the hippocampal formation of an adult mammalian to the quinolinic acid toxicity, has been investigated with great interest (Schwarcz et al. 1984; Taraszewska et al. 1991; Kida and Matyja 1990; Speciale et al. 1987). Yet there is little information on the course of the foetal development. Hence, in our experiments, quinolinic acid was administered to the mother throughout the gestation period in order to mimic the congenital metabolic disturbances resulting from an excess of quinolinic acid within foetal tissues.(ABSTRACT TRUNCATED AT 250 WORDS)

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The effect of quinolinic acid administered during pregnancy on liver cells of rat offspring (ultrastructural investigation).

Liver cells of rat's offspring were ultrastructurally examined after administering quinolinic acid to mothers intraperitoneally in a dose of 60 mmol or 100 mmol, once daily, throughout the entire gestation period. Liver tissue specimens were taken on day 5 after birth from experimental and control animals. Administration of quinolinic acid resulted in a marked proliferation of smooth elements of endoplasmic reticulum in liver cells of their offspring, which indicated microsomal enzymatic induction. Simultaneously, injuries of liver cells of varying intensity were observed, which were dose-dependent on quinolinic acid administration, the injured cells being more frequent at higher doses of the drug.

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PubMedDate not supplied

Quinolinic acid: effect on neurons of the paraventricular nucleus of the hypothalamus.

Quinolinic acid was administered intraperitoneally to male Wistar rats in a dose of 60 mmol, once daily for 8 days. The neuronal cell bodies in the paraventricular nucleus of the hypothalamus of quinolinic acid-treated rats exhibited electron microscopic features of increased cellular activity but some damage of neuronal cell bodies was also present. After quinolinic acid treatment, damaged cells predominated within the parvocellular division of the nucleus. The cells varied with respect to the degree of their damage. Besides, the cells exhibiting an increased activity, as well as those looking normally, were also present. In the magnocellular division of the nucleus, the cells exhibiting an increased activity predominated, although some forms of damage could also be distinguished.

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