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Biomedical subjects

M Bernat

Publications and source records attributed to M Bernat.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Idiopathic hypercalciuria. Correlative study of bone tissue and phosphocalcium investigations].

The authors report on the clinical, biological and radiological anomalies observed in a series of 42 cases of idiopathic hypercalciuria. An histological bone study showed "osteomalacia" type changes (an increase in the osteoid volume and a decrease in the mineralization speed). The Ca45 isotope studies showed that there was an exchangable pool of calcium and a turnover, which was generally low. A study of the kidney functions revealed a decrease in the tubular reabsorption of calcium, while that of phosphorous remained within normal limits. There was no case of hyperparathyroidism in this series. The authors pose the question of whether the failure of calcium to settle on the tissues and the lack of tubular reabsorption of calcium, does not result from the relatively ineffective action of the endogenous circulating parathyroid hormone.

Adolescent↗
PubMed1978

[Vitamin-resistant osteomalacias of hepatic origin in the adult].

The authors report two cases of vitamin resistant osteomalacia in an adult connected with an apparent inability of the liver to hydroxylate vitamin D. One of the cases showed a case of pseudo-hypo parathyroidism of type II, reversible by the administration of calcium. The other case demonstrated vertebral hyperossification. Treated with 25 hydroxycholecalciferol in physiological dosage an improvement in the clinical, biochemical and histological states resulted.

Female↗
PubMed1978

[The provoked hypercalciuria test. Significance and limitations].

The calcium tolerance test is of diagnostic importance only in osteomalacia, which it helps to identify before bone biopsy when the static phosphocalcic parameters are not a deciding factor. However, the test does not make it possible to distinguish an osteoporosis from a cortisone osteopathy or an idiopathic hypercalciuria. In the first two diseases, the rates of urinary calcium elimination are comparable to that of normal individuals. It seems that the rate of urinary elimination of I.V. administered calcium is, approximately, all the more elevated as the level of iPTH is low; and, when the level of iPTH is low, the osteoid tissue seems less calcified than normally.

Adult↗
PubMed1975

[Test for hypocalcemia due to calcitonin in the normal subject and in patients with osteoporosis or Paget's disease. Preliminary results].

The authors report the variations in calcaemia and in circulating immunoreactive PTH produced by the intramuscular injection of 5 units of porcine calcitonin in normal subjects and in patients suffering from osteoporosis or Paget's disease. After having determined the levels of 25-hydroxy-vitamin D circulating in the different groups, the authors note that comparison of these variations makes it possible to regroup the different types of reaction following the injection of the hypocalcaemic hormone. In patients suffering from pure osteoporosis, hypocalcaemia was slow to appear, was of moderate intensity, but was prolonged. The osteoporo-malacia patients did not produce a specific reaction and certain of them appeared "insensitive" to calcitonin. Results obtained in patients with Paget's disease confirm the hypocalaemic action of calcitonin even at a low dosage. With this test, the authors hope to contribute to studies of demineralizing affections and to overcoming them.

Adult↗