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Biomedical subjects

M Bergman

Publications and source records attributed to M Bergman.

At least 163 records · Page 9Linked to original sources

Influence of supply of heat to cobalt-chromium frameworks during soldering and subsequent hardening heat treatment of wrought clasps.

Retentive clasp arms of wrought gold alloy wire were soldered to frameworks made of three dental cobalt-chromium alloys. The clasps were then subjected to a conventional hardening heat treatment. Microstructure and hardness of the cobalt-chromium alloys were determined before and after these operations. The results reveal that the supply of heat during soldering and hardening heat treatment of the clasp does not influence the microstructure and hardness of the cobalt-chromium alloys.

Chromium Alloys↗

Potentials of and currents between dental metallic restorations.

115 persons were studied from a body of patients referred to the Faculty of Odontology, University of Umeå, for investigation regarding any occurrence of oral galvanism. Potential and polarization of metallic restorations and dentures were recorded using a method and equipment previously described. Data regarding distribution of potential ranges with respect to number of patients and type of alloy are presented. The distribution of calculated intraoral currents in relation to number and type of metallic contacts is stated. Relevant parameters for the study of oral galvanic (bimetallic) cells are discussed.

Adult↗

Nickel allergy and nickel-containing dental alloys.

Test pieces from five cobalt-chromium casting alloys intended for use in removable partial dentures were attached to the skin of 10 women with known allergy to nickel. Patch tests were also performed with nickel and cobalt salts. Nine of the 10 women showed clear-cut or strong patch test reactions to the alloy with 7% nickel, one patient also to one of the other alloys (less than 1% nickel). In five patients with contact allergy reactions to both nickel and cobalt salts mild or marked responses to some of the other alloys were observed. Corresponding observations were made in three out of the five patients with contact allergy reactions to nickel salt but not cobalt salt.

Adult↗

Appearance of surfaces of dental amalgam in contact with gold. An in vivo study.

90 combined gold-amalgam specimens of three dental gold alloys and two amalgams were placed subcutaneously, intraperitoneally and in the cheek pouches of 15 golden hamsters. The appearance of the amalgam surfaces after one week was evaluated using scanning electron microscopy and light microscopy. The results showed that among the implants there was an obvious difference between the conventional amalgam and the non-y2 amalgam specimens as regards accumulation of plaque, which was much more pronounced on the conventional amalgams. The cheek pouch specimens with conventional amalgams differed markedly from the corresponding implant specimens, showing very little plaque accumulation. Some possible explanations for these observations are discussed.

Animals↗

Intensive ambulatory treatment of insulin-dependent diabetes.

The therapy for insulin-dependent diabetes has been changing in the last 3 years with the increasing application of intensive ambulatory treatment programs involving self-monitoring of blood glucose levels by the patient. Insulin is administered either as multiple manual daily injections or as a continuous subcutaneous infusion delivered by a portable pump. We discuss the implementation, efficacy, complications (including recent reports of deaths in pump-treated patients), and cost of such programs. The potential effectiveness in preventing the long-term complications of diabetes warrants offering a program of self-monitoring of blood glucose levels combined with multiple manual daily insulin injections as a routine treatment option to virtually all patients with insulin-dependent diabetes. Additional observations on safety and efficacy are needed before insulin pump treatment can be considered a routine option. Furthermore, whether intensive treatment involving either manual or pump administration of insulin alters the risk of hypoglycemia as compared with conventional management remains to be established.

Ambulatory Care↗

Insulin-infusion-pump treatment of diabetes: influence of improved metabolic control on plasma somatomedin levels.

We examined whether changes in somatomedin accompany those seen in glucose and growth hormone during treatment with the insulin-infusion pump. somatomedin levels in eight insulin-dependent diabetics (13 to 29 years of age) were measured before and after 16 weeks of outpatient insulin-pump treatment, which lowered mean glucose from 245 +/- 21 to 100 +/- 5 mg per deciliter and total glycosylated hemoglobin from 16.2 +/- 1.2 to 9.7 +/- 0.3 per cent (mean +/- S.E.M.). During conventional insulin therapy, both total somatomedin and somatomedin C were within the normal range, despite elevations in growth hormone. Pump treatment resulted in a 70 to 75 per cent increase in both total somatomedin and somatomedin C (P less than 0.05) and a fall in growth-hormone concentrations. In the two growing adolescents, growth velocity doubled during 13 to 15 months of pump treatment. Our data suggest that the improved insulin delivery or metabolic control increases somatomedin levels despite a decrease in growth hormone. Thus, insulin-pump treatment may be useful in optimizing growth in diabetic children.

Adolescent↗

Cortisone-induced remission of hypothyroidism in Schmidt's syndrome.

A patient with autoimmune Addison's disease, hypothyroidism and primary gonadal insufficiency is described. Initial treatment with cortisone improved his thyroid function, probably through cortisone suppression of the autoimmune reactions. It was, however, not possible to normalize the thyroid function completely. The decreased testicular function did not improve during the cortisone treatment.

Addison Disease↗

The distribution of nickel in mice. An autoradiographic study.

Metallic restorations are corroded in the oral environment. Corrosion products penetrate into the tissues and are distributed throughout the body seeking certain organs and tissues as targets. The distribution patterns of nickel in albino mice were studied autoradiographically at various periods after an intravenous injection of 63Ni in order to locate the target organs and tissues of nickel. With short survival periods the highest uptake of 63Ni was found in the blood, kidney, urinary bladder, lung, eye and hair follicles. With long survival periods, 3 weeks, the distribution pattern was dominated by high uptake in the lung tissues, central nervous system, kidneys, hard tissues and skin. The distribution pattern in brown mice was similar to that in albino mice. However, the concentration in the eye and the skin was more pronounced. The importance of release of nickel from nickel containing dental alloys in nickel allergic patients is discussed.

Animals↗

Tissue accumulation of nickel released due to electrochemical corrosion of non-precious dental casting alloys.

Specimens of four non-precious dental casting alloys intended for use in the ceramic-metal technique were implanted subcutaneously in the neck region of mice. The animals were killed after 5 months. Organs and tissues were tested as regards the concentration of nickel by means of atomic absorption spectrophotometry. The study showed that due to electrochemical corrosion nickel was released from implants and accumulated in some tissues and organs.

Animals↗