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Biomedical subjects

M Bergener

Publications and source records attributed to M Bergener.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Possibilities and problems in the rehabilitation of aged patients with mental illness (author's transl)].

In the Federal Republic of Germany as in other Western Countries institutions suitable for the rehabilitation of aged patients with mental illness are lacking. As long as "psychiatry of the higher age" is synonymous to "psychiatry of demented patients" the term "rehabilitation" means only a slogan, not a maxime. Jurisdiction in the Supreme Court though, has shown the way of going on. It will depend also on the attitude of the doctors in charge of the patients to fulfill the expectations posed in that jurisdiction and to reach so the far set marks in the interest of the patients. Big institutional deficits have to be ameliorated as far as possible; of prime importance here is the necessity to place the opportunities for the employment of qualified employees. Rehabilitation instead of custodial care here is synonymous for efficiency and humanity. The change from an obsolete and nonorganized "system" of care to a modern network of rehabilitation should be obtained by voluntary cooperation and by voluntary coordination of medical and social institutions. So an integration of all possibilities of help to a network could be reached.

Aged↗
PubMed1978

[Double blind study on maprotiline, an example of a multidimensional psychopharmacologic experiment (author's transl)].

Antidepressive therapy with maprotiline was accompanied by blood level determinations psychological clinical and electroencephalographical assessments. It was the aim of the study to introduce objective methods in psychotropic drug therapy and to look for a relationship between blood level and clinical outcome, EEG and psychological data. We found a "therapeutical window" of blood levels between 300 to 600 ng/ml of maprotiline (oral dose of 75 or 150 mg per day). There is also a relationship between clinical outcome rated by the Hamilton-Depression-Scale and the d2-cancellation-test.

Administration, Oral↗
PubMed1976

[Multidimensional pharmacopsychiatry in gerontopsychiatry: studies on the therapy with tricyclic antidepressant drugs (author's transl)].

A Concept for the multidimensional assessment and correlation of serum level and outcome of therapy with psychomopharmaca with chemical, psychological, psychophysiological, electroencephalographical and clinical methods is shown. It is possible by this method to correlate clinical outcome to serum level and effect of the drug and to objectivate the efficacy of the pharmacon. Applications in Gerontopsychiatry are discussed.

Aged↗
PubMed1976

[Multidimensional diagnostics in pharmacopsychiatry/results of therapy with desmethyl-loxapine (author's transl)].

In view of the particular problems of psychiatric classification the advantages and disadvantages of standardised rating scales are discussed. The result is that these instruments at present are irreplaceable in psychopathological research on behalf of their reliability in transmitting information and the possibility of quantifying psychopathological syndromes. The practice of 4 rating scales, which are still uncustomary mainly in the area of German language, is demonstrated by means of a psychopharmacological investigation example. These rating scales are: 1. the Hamilton Psychiatric Rating Scale for Depression, 2. the Wittenborn Psychiatric Rating Scale, 3. the Structured clinical Interview (Burdock and Hardesty) and 4. the Befindlichkeitsskala (Condition Scale) (v. Zerssen). Within a duration of treatment of 3 and 4 weeks desmethyl-loxapine [CL 67 772, 2-chloro-11-(1-piperazinyl)-dibenz (b,f)(1,4)-oxazepine] was tested in an open study as an antidepressant on 16 patients with different depressive syndromes. The results of treatment, which can be considered positive, are represented and discussed in an intra-individual pre- and after-treatment comparison in respect of the differences between these scales. The good therapeutic efficacy of desmethyl-loxapine results mainly from a marked anxiolytic effect. All the clinical and chemical examinations performed point out an excellent tolerance of this drug. German versions of standardised rating scales appear urgently indicated.

Depression↗
PubMed1975

[The significance of standardized evaluation scales in psychiatric diagnosis as exemplified by the therapeutic intervention with desmethyl-loxapine (author's transl)].

Taking into account the particular problems of psychiatric classification the advantages and disadvantages of standardised rating scales are discussed. The authors come to the conclusion that these instruments at present are irreplaceable in psychopathological research because of their reliability in transmitting information and the possibility of quantifying psychopathological syndromes. The use of four rating scales which are little known yet within German speaking countries in demonstrated by means of a psychopharmacological investigation on the clinical effects of Desmethyl-Loxapine. These rating scales are: 1. the Hamilton-Psychiatric-Rating-Scale for Depression 2. the Wittenborn-Psychiatric-Rating-Scale 3. the Structured Clinical Interview (Burdock and Hardesty) and 4. the Befindlichkeits-Skala (Condition-Scale). Desmethyl-Loxapine was given in an open study as an antidepressant to 16 patients with different depressive syndromes. The results of treatment which lasted 3 to 4 weeks are discussed. The good therapeutic efficacy of Desmethyl-Loxapine was mainly due to its marked anxiolytic effect. All accomplished clinical examinations showed an excellent tolerance of this drug.

Animals↗