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Biomedical subjects

M Berard

Publications and source records attributed to M Berard.

At least 37 records · Page 2Linked to original sources
PubMed1994

Prediction of recreational therapy behavior of hospitalized adolescents from a behavior classification instrument.

The purpose of this study was to estimate the validity of an instrument of the Adolescent Behavioral Classification Project in predicting behavior patterns of emotionally disturbed adolescents in an inpatient setting. Subjects (n = 126) were adolescents admitted to a state residential treatment unit across a period of 35 months. Predictor variables were scores on 17 or 25 factors of the instrument from both adolescents' own responses and their mothers' responses on their behalf. Criterion variables were 10 recreational therapy factors, especially 4 temporally stable factors, and length-of-time in treatment. 3 phases of the project were (I) behavior during initial stages of the therapy, (II) behavioral change after 3 months of therapy, and (III) length-of-time in treatment. In Phase I, both mothers' and adolescents' responses produced significant correlations with criteria; however, in Phase II only the adolescent students' 25 ABCP factors predicted behavioral change. In Phase III, adolescents' responses but not their mothers' responses classified the adolescents by length-of-time in treatment.

Adolescent↗
PubMed1994

Plasma thrombomodulin level in malignancy varies according to the tumor type.

Plasma thrombomodulin (TM) level was measured by ELISA in patients with either digestive tract cancers or malignant melanomas. A striking difference was seen between tumor types with an increase in the TM level of the former and a decrease in the latter. This finding is in agreement with the classification of tumors previously proposed by Zacharski et al.

Digestive System Neoplasms↗
PubMed1993

Antiphosphatidylethanolamine antibodies in systemic lupus erythematosus.

Antiphosphatidylethanolamine antibodies (aPEA) were investigated in a population of 78 systemic lupus erythematosus (SLE) patients, by means of an enzyme-linked immunosorbent assay method. These antibodies are specifically directed against phosphatidylethanolamine, one of the zwitterionic phospholipids present in cell membranes. Antiphosphatidylethanolamine antibodies were found in 13 patients (16.6%). They were generally associated with lupus anticoagulant (two patients), antiphospholipid antibodies directed against anionic phospholipids (six patients), or both (four patients). In only one case, aPEA were the sole detectable antiphospholipid antibodies. Thrombosis, recurrent fetal loss, valvular disease or neurological involvement was present in most (11 of 13) of the patients with aPEA. It seems valuable to carry on further searches for these antibodies in SLE, since patients with aPEA are at higher risk of thrombosis and/or recurrent fetal losses than are patients with antiphospholipid antibodies (anticardiolipin, anti-anionic phospholipid and/or lupus anticoagulant) other than aPEA. Moreover, since aPEA can be the sole detectable antiphospholipid antibodies, they should be investigated in SLE with thrombosis when neither lupus anticoagulant nor anticardiolipin antibodies can be demonstrated.

Adolescent↗
PubMed1993

Plasma reactivity to hexagonal II phase phosphatidylethanolamine is more frequently associated with lupus anticoagulant than with antiphosphatidylethanolamine antibodies.

In membranes, phosphatidylethanolamine (PE) is usually in a lamellar phase, but it can also adopt a hexagonal II phase (HexII PE), which has been demonstrated to be immunogenic in mice and has recently been used in a new clotting assay to detect lupus anticoagulant (LA). A population of 58 patients susceptible of having LA or antiphospholipid antibodies (aPLA), was screened for reactivity to HexII PE using the new clotting assay and for the presence of anti-PE antibodies (aPEA) using ELISA. The patients could be classified as follows: 26 systemic lupus erythematosus, 14 primary antiphospholipid syndromes and 18 miscellaneous non autoimmune disorders. HexII PE reactivity was detected in 22 patients. It was significantly more often associated with LA-positivity (20/29) than with LA-negativity (2/29), (p < 0.0001). However, 9 patients with LA had negative HexII PE assays. Anti-PE antibodies were detected by ELISA in only 12% of the cases. No correlation was observed between the distribution of aPEA and that of HexII PE reactivity. Interestingly, 2 LA- and aPLA-negative patients exhibited HexII PE reactivity. The absence of identity between the distribution of HexII PE reactivity and that of either LA or aPEA indicates that this new assay has its own specificity. It might detect antibodies to the immunogenic hexagonal PE and may therefore have a broader scope than that proposed initially. Although in the studied populations, no significant relationship could be found between HexII PE positivity and clinical complications (thrombosis and/or recurrent fetal losses), it might be associated with other complications of the antiphospholipid syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

[Diagnostic problems posed by inflammatory pseudotumors of the orbit: study of 3 cases].

Orbital inflammatory pseudo-tumor is a rare benign condition not always very well known by pathologists. Clinical characteristics and laboratory data were reviewed in 3 affected patients (one child, two adults). Changes in orbital tissues were described according to various histopathological classifications reported in literature. The authors stressed the difficulties to diagnose such a lesion and to eliminate the possibility of either eosinophilic granuloma or rhabdomyosarcoma in infants. As in most cases the disease responded favourably to steroids and its etiology was unknown. Relapses, bilateralization and bad effect of biopsy should be considered.

Adolescent↗
PubMed1986

Tumor immunoglobulin with antibody activity against blood coagulation factors.

A cultured tumor cell line from the Greene lymphoma was shown in vitro to secrete immunoglobins of the IgG2 subclass (TcIg), which possessed a direct inhibiting effect on blood coagulation. TcIg prolonged the thrombin time (TT) of normal hamster plasma in vitro. Moreover, the effect of heparin which prolonged the plasma thrombin time was reinforced when TcIg was added to the test. This property was not neutralized by protamine sulfate. In the plasma kaolin clotting time test (KCT), the addition of TcIg lead to an anticoagulant effect, but weaker than in TT. The mixing pattern of normal plasma with tumor-bearing hamster plasma did not reveal the presence of circulating inhibitor in tumor plasma. It was suggested that TcIg had heparin-like activity.

Animals↗
PubMed1985

Herpes simplex virus antigen detection in human acute encephalitis: an immunohistochemical study using avidin-biotin-peroxidase complex method.

Autopsy specimens from six patients with clinically diagnosed herpes simplex virus (HSV) encephalitis were studied. Since immunocytochemistry has been reported to be a more reliable and successful method to identify HSV as the etiologic agent, antitype 1 HSV (HSV1) and antitype 2 HSV (HSV2) and the avidin-biotin-peroxidase complex (ABC) method were applied to brain paraffin sections. Positive immunostaining was observed in front-orbital, mediobasal temporal lobes, cingulate gyrus, and insula. The staining was bilateral but predominant on one side. In neurons, the cytoplasmic staining was prominent in perikarya and processes, less often observed in nuclei, rarely seen in nuclear inclusions. The positive staining was intense in oligodendrocytes and macrophages, in both nuclei and cytoplasm. In two cases astrocytic processes were stained strongly. Perivascular lymphocytes were always negative. Positive reactions were obtained with both anti-HSV1 and anti-HSV2 but weaker with anti-HSV2. This results suggests that, because of its high sensitivity, ABC method permits viral antigen detection not feasible with other methods. However, this method lacks of accuracy for HSV typing mainly because of probable antigens changes resulting from tissue processing.

Adolescent↗
PubMed1985

[Melanic proliferations of the conjunctiva. Histopathologic study of a series of 40 cases].

A retrospective study of 40 melanocytic conjunctival tumors (22 naevi and 18 malignant melanoma) is reported. Cases of non-degenerated conjunctival melanosis were not observed. The particular aspects of diagnosis and the prognostic behaviour of these proliferations are discussed and compared with their cutaneous homologues. Epithelial inclusions within tumor cell proliferation are considered as the best criterion of benignity. Because conjunctival melanomas are rather uncommon and technical difficulties in their study are very frequent (poor quality of tissue samples, small size of specimens) many reports are contradictory. Some diagnostic signs are specific for this kind of tumor in the conjunctiva: nevertheless, the particular conjunctival anatomy makes it impossible to classify according to criteria defined for cutaneous malignant melanoma. No criteria would have a predictive value. The severe prognosis of conjunctival melanoma (44% deaths in the present series over 10 years after diagnosis) has been underestimated. Most often carcinologic therapies have not been used in previously reported cases.

Adolescent↗
PubMed1981

Experimental hexachlorophene encephalopathy in mice and baboons: light and electron microscopic study.

An experimental study on acute Hexachlorophene (HCP) neurotoxicity is reported in mice and baboons: - by light microscopy, a severe spongiform lesion of the central nervous system is localized in the white matter without myelin breakdown or cellular reaction; - by electron microscopy, the myelin alteration is characterized by the presence of vacuolation of "splitting" in the intralamellar spaces of compact sheaths; myelinated axons are occasionally involved. The changes described are discussed according to various reports on HCP neurotoxicity in humans and experimental animals. The effects of this chemical agent on the central nervous system is related to the percentage of HCP in talcum powder or solution for topical use. The toxicity of very low dosage level is demonstrated in baboons. Therefore HCP use cannot be recommended for young infants.

Administration, Topical↗
PubMed1979

[Semi-automatic assay of post-heparin plasma lipoprotein lipase activity (author's transl)].

A simple method for the assay of post-heparin plasma lipoprotein lipase activity is described. The substrate was a stable intralipid solution. The amount of fatty acids released in the 37 degrees C incubation medium was measured several time during the reaction course, by light absorption on a Technicon auto-analyzer. By plotting these values on a graph paper, the curve of the post-heparin plasma lipoprotein lipase activity was obtained.

Autoanalysis↗
PubMed1978

[Ultrastructural study of meningiothelial meningioma with 'hyaline inclusions' (author's transl)].

One case of meningiothelial meningioma with "hyaline inclusions" (colloid-bodies or pseudopsammomas) as noted by Cushing and Eisenhardt (1938) and by Kepes (1961-1975) is reported by light and electron microscopy. Two types of these structures, either homogeneous or polymorphic, surrounded by microvilli are described and regarded as signs of secretory differentiation of tumor cells. In addition to Kepes' description, the authors show, at high magnification, the polymorphic material including homogeneous component, lamellar structures, microvesicles and dense bodies. The endocellular overproduction of the various types of "hyaline inclusions" and the nature of their material are discussed.

Female↗
PubMed1978

[Light and electron microscopy in one case of herpes zoster keratitis (author's transl)].

One case of herpes zoster keratitis studied after corneal graft is described. Light and electron microscopy investigations show severe pathological changes under the coneal epithelium: Bowman's layer disruption, superficial stromal alterations, sub-epithelial phagocyte proliferation with lipid and mucopolysaccharid vacuolar deposits, abnormal vascularization of the posterior stroma. The authors stress on this interesting ultrastructural study because of very rare cases of the same disease reported in the literature.

Cornea↗