Biomedical subjects
M Berényi
Publications and source records attributed to M Berényi.
[Renal gravel formation inducing renal insufficiency as a side-effect of ceftriaxon].
Ceftriaxon is a third-generation cephalosporin with a wide and powerful spectrum of antimicrobal activity. It is often used in pediatrics. The authors draw the attention to the side-effect of the medicament, which might cause renal gravel-formation. They report a case of a 9-years old boy, who suffered from ceftriaxone-associated cholelithiasis and hephrolithiasis, which induced anuria and uraemia.
Characterization of calcified deposits on contraceptive intrauterine devices.
The formation of calcified deposits on > 200 contraceptive intrauterine devices (IUD) was quantitated as a function of time in healthy women, pregnant women, and women with a pathologic lesion. The incrustment formation was significantly enhanced when inflammation occurred, but change could not be observed in cases of pregnancy. The incrustments were analyzed by x-ray diffraction, infrared spectroscopy, x-ray microprobe, and ultramicrochemical stone analysis techniques. Major components and their average w/w percent quantities in the incrustments are as follows: calcium carbonate 75%, apatite 5%, and organic matrix 20%. Earlier hypotheses on the chemical processes of deposit formation are discussed, and a new, ionic mechanism of calcification on IUD surfaces is suggested.
Stable electrotransformation of symbiont candidate diazotrophic bacterium with plasmids carrying selectable and screenable marker genes.
Nitrogen-fixing symbioses had been established between the originally asymbiotic soil bacterium Azotobacter vinelandii CCM289 and different lower and higher plant species. Better characterization and further development of such artificial systems require a reliable genetic transformation method for the introduction of marker genes into symbiont candidates. The performance of electroporation was evaluated using pJB3 (4.8 kb), pBI121 (12.8 kb) and pFAJ31.2 (24 kb) plasmid DNAs containing selectable (Ap, Km, Tc) and screenable (gusA, lacZ) marker genes. The adapted methods for the preparation of transformation-competent azotobacters and their electroporation (18 kV/cm electric field strength, 5 ms time constant, 0 degree C) provided up to 6.8 x 10(5) transformants per microgram plasmid DNA, which is about 10(3) times the transformation efficiency achieved in control experiments. No electrotransformants were obtained with the 24-kb pFAJ31.2. The size of plasmid DNA did not significantly affect the efficiency of transformation. Transformants were able to grow at antibiotic concentrations that were 100-200 times greater than the lowest amounts that completely inhibited the growth of wild-type bacteria. A constitutive expression of gusA gene was observed in transformants with the CaMV 35S promoter-gusA fusion containing pBI121, while lacZ expression was not detected under the control of the lac promoter in pJB3 transformants. Electroporated plasmids were reisolated from transformants in their original form, while non-transformed bacteria did not contain indigenous plasmids. PCR amplification and Southern DNA blot hybridization showed the integration of plasmid DNA into the host genome as well. Transformants retained their nitrogen-fixing ability and had normal morphological and growth characteristics. Experimental findings proved the stable maintenance of plasmid DNA in azotobacters, making possible the routine transformation and detection of these symbiont candidates.
[ESWL in renal tubular acidosis].
ESWL is a suitable modality for the management of lithiasis caused by RTA, especially in case of renal or ureteric stones. Smash of calculi in ducts of Bellini is worthy to be considered if the fragments can get into the renal pelvic space and the renal function improve. At present it is still a matter of discussion.
[Complex therapy of cystine calculi].
Authors report their experiences with management of cystine urolithiasis between 1975-1992. 61 patients were observed and treated with dietotherapy, medicaments, open surgery, percutaneous nephrolithotomy and extracorporeal shock wave lithotripsy. Difficulties of treatment of this rare stone have been demonstrated with data of 3 patients (lack of screening and early diagnosis, unsystematic prophylaxis, formation of large stones).
[Hungary/East Germany--Urinary Calculus Symposium Budapest 19/20 April 1990].
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Prophylaxis of oxalate urolithiasis with alkaline citrates.
Hypocitraturia, hypercalciuria, hypokalaemia, and some form of acidosis are often characteristic accompanying symptoms of calcium containing urinary stone formation. These alterations may be controlled or normalized with the administration of alkaline citrates which slow the relative growth rate of calcium oxalate crystals down. In response to the administration of a single 2-g dose of Magurlit granulate, also regarded as alkaline citrate, citrate excretion increases, urinary Ca/citrate, Ca/creatinine, and Ca.P/creatinine quotients decrease. Since these changes of the urinary constituents are advantageous as far as the prophylaxis of stone formation is considered and may be observed following the administration of other citrate mixtures as well the application of Magurlit is recommended for the prevention of calcium oxalate stones and for the treatment of distal renal tubular acidosis.
The antiallatal effects on locusts and lethal effects on nematodes of synthetic precocene-1 derivatives differing at the carbon 7 position.
Fourteen precocene-1 (P1) derivatives differing at C-7 were synthetized and tested for their antiallatal activities on Locusta migratoria (in vitro and in vivo) and nematocidal effects on Caenorhaditis elegans. An outstanding antiallatal effect was produced by 7-propargyloxy-P1 in vitro. It caused an elevated rate of mortality when applied in vivo to locusts or nematodes. The antiallatal effect of 7-cyclopentyloxy-P1 was not accompanied by toxicity. Aralkyloxy substitution at C-7 eliminated the precocene activity.
Echographic evaluation of the incrustation of intrauterine contraceptive devices (IUD).
The ultrasonographic study of Intrauterine Contraceptive Devices (IUD) is reported. In their earlier investigations authors have shown that, after a prolonged use of IUD, incrustation develops over the surface of the IUD. The presence of an incrustate could be observed both during in vitro as well as in vivo ultrasonographic studies.
[Incrustation of the IUD, demonstrated by ultrasonography].
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Morphological characteristics of incrustates of intrauterine contraceptive devices.
The morphology of incrustates formed on intrauterine contraceptive devices (IUD) is described. It is demonstrated that due to manufacturing technology some IUDs have long, parallel excavations serving as sites for incrustate formation. A regional difference of incrustation on the different parts of IUD has also been observed. Electron microscopy was carried out in tissue fragments attached to removed IUDs. Alterations correspond to acute or chronic inflammation. Incrustate on the surface of IUD appears to have a primary role in induction of the process.
[Incrustation of marker threads of intrauterine devices in the uterine cavity and cervix uteri].
If the indicating thread of intrauterine contraceptive devices is situated inside the uterine cavity, it is incrustated in the same way with calcium carbonate like the device itself. In 20 per cent the intracervical part of the thread is incrustated, too. The danger of an ascending inflammatory disease is increasing with the precipitation of substances, probably, denaturated fibrine or mucine according to the infrared spectral analysis.
A rare enzyme deficiency causing formation of 2,8-dihydroxyadenine (purine body) calculi.
Deficiency in the enzyme adenine-phosphoribosyltransferase (APRT) has given rise to the formation of 2,8-dihydroxyadenine calculi, which are extremely rare. It is the first case of this kind reported in Hungary.
Use of Reanal stone analyser kit for the analysis of ignition residue of urinary calculi.
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Correlation between the incrustation of intrauterine devices and the duration of their use.
The usefulness and side-effects of intrauterine contraceptive devices (IUDs) are evaluated on the basis of various aspects (e. g. effect of postabortal and post-partal insertion, expulsion of device, frequency of pregnancies, bleeding and inflammation, etc.) [1, 2, 3, 4]. However, the incrustation of the device has been ignored although the coating on the major part of the surface is easy to study. The rough surface coating is very likely to be associated with some side-effects [5]. In our report we have tried to find some links between the degree of incrustation and the duration of using the device.
[Significance of giant sperm in andrologic diagnosis].
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[Complications from the use of IUD].
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