Correlation between biological potency and biodegradation of a somatostatin analogue.
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Aminopeptidases↗
Biomedical subjects
M Benuck
Publications and source records attributed to M Benuck.
On the sequential cleavage of myelin basic protein by cathepsins A and D.
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Animals↗
Enzymatic inactivation of substance P by a partially purified enzyme from rat brain.
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Amino Acids↗
Metabolic instability of myelin proteins. Breakdown of basic protein induced by brain cathepsin D.
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Amino Acids↗
Aminotransferase activity in brain.
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Alanine Transaminase↗
Hydrolysis of myelin basic protein with brain acid proteinase.
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Amino Acid Sequence↗
The effect of elevated amino acids on aminotransferase levels in brain and liver of the mouse.
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Administration, Oral↗
Regional and subcellular distribution of aminotransferases in rat brain.
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Alanine↗
Transamination of amino acids in homogenates of rat brzain.
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Age Factors↗
Formation of asparagine from aspartic acid in rat brain.
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Adenosine Triphosphatases↗
Acetyl transport mechanisms. Metabolism of N-acetyl-L-aspartic acid in the non-nervous tissues of the rat.
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Acetates↗
Metabolism of a heptapeptide opioid by rat brain and cardiac tissue.
Met-enkephalin-Arg6-Phe7 (E7) is converted to Met-enkephalin by rat striatal membranes; in contrast, Leu-enkephalin (E5) is inactivated by cleavage at the Tyr-Gly (aminopeptidase) and Gly-Phe sites (metalloendopeptidase). Conversion of E7 is inhibited by MK-421, and inactivation of E5 is inhibited by bestatin and Thiorphan. Purified brain angiotensin converting enzyme (EC 3.4.15.1) also converts E7 but a purified metalloendopeptidase acts on both E5 and E7 at the Gly-Phe site. Cleavage of E7-amide by metalloendopeptidase leads to release of Phe-Met-Arg-Phe-amide, a cardioactive neuropeptide. Rat heart, a potential target organ, does not convert E7-amide to release the cardioactive peptide but cleaves the Met5-Arg6 bond to release Met-enkephalin by an enzyme sensitive to MK-421.
Animals↗