Search PubMed⌕ Search

Biomedical subjects

M Ben-Bassat

Publications and source records attributed to M Ben-Bassat.

At least 55 records · Page 3Linked to original sources
PubMed1985

Rejection-related nephrotic syndrome associated with massive antiglomerular and antitubular basement membrane deposits.

A patient with end-stage renal disease due to nephronophthisis developed nephrotic syndrome following renal transplantation. Renal biopsy revealed rejection glomerulopathy with massive linear deposition of immunoglobulin (Ig) G and complement C3 along the glomerular and tubular basement membranes. The association of nephrotic syndrome with linear deposition of Ig is rare in chronic rejection of kidney allografts. The nephrotic syndrome in this case responded to treatment with plasmapheresis.

Adolescent↗
PubMed1985

Levan-induced glomerulitis in rabbits: a possible role for direct complement activation in situ.

Since high-molecular-weight levan is known to reduce capillary permeability to large molecules, an experiment was designed to investigate whether this agent may attenuate the glomerulonephritis associated with acute serum sickness in rabbits. The study, in fact, demonstrated an enhancing effect of levan, which caused increased glomerular proliferative changes and leucocyte infiltration and, possibly, increased IgG deposition in this experimental model. In addition, rabbits injected only with levan also demonstrated mild glomerulitis and C3 deposition. In one of four rabbits examined, this was accompanied by a marked fall in the serum level of total haemolysing complement. Levan was demonstrated to cause activation of complement when incubated with normal rabbit serum in vitro. We believe that these findings are best explained on the basis of complement activation in situ by levan in the glomeruli, probably via the alternative pathway, with the resulting inflammatory response. In the case of BSA-injected rabbits, this response is believed to be additive to that of the classical immune complex-mediated complement activation.

Animals↗
PubMed1984

The CO2 laser in pediatric surgery.

The CO2 laser has found its place in surgery and is now an accepted modality in many fields. Its application in pediatric surgery is well based and it is our opinion that its use in this field should be more widespread.

Carbon Dioxide↗
PubMed1984

A solitary subcutaneous nodule as a presenting sign of metastatic malignant melanoma.

Two patients were referred because of an innocent-appearing solitary subcutaneous nodule; excision revealed metastasis of malignant melanoma, but comprehensive investigation failed to disclose the primary tumor. In neither patient was there subsequent evidence of local recurrence but both died of disseminated disease--the first 2 years and the second 10 months after the excision.

Adult↗
PubMed1984

Massive proteinuria in patients with chronic pyelonephritis.

Massive proteinuria associated with chronic pyelonephritis is reported in five patients. Two of them were known to have vesicoureteral reflux, whereas three had minor predisposing factors only. None of the patients were in severe renal failure or suffered from severe hypertension at the time of massive proteinuria. Results of histological examinations were compatible with a diagnosis of chronic pyelonephritis. Electron microscopy and immunological studies did not show any primary glomerular lesions.

Adult↗
PubMed1983

The clinicopathologic features of cryoglobulinemic nephropathy.

Renal biopsy specimens from eight patients with cryoglobulinemic nephropathy were examined by light, electron, and immunofluorescence microscopy. The light microscopic features were not diagnostic. Characteristic ultrastructural findings were observed in all except one specimen and consisted of glomerular electron-dense deposits, which had a coarse, granular appearance at low-power magnifications and revealed tubular, annular and in a few cases, also fibrillar structures at high-power magnifications. Subendothelial deposits were a constant finding. The presence of intravascular thrombi (deposits), osmiophilic bodies, and crystals within the cytoplasm of the glomerular cells are also helpful for the diagnosis of this entity. Because of these specific findings, cryoglobulinemic nephropathy should be recognized as a clinicopathologic entity.

Adolescent↗
PubMed1982

Small skin blood vessel occlusions by cryoglobulin aggregates in ulcerative lesions in IgM-IgG cryoglobulinemia.

The skin biopsy specimens from six patients with primary mixed IgM-IgG cryoglobulinemia were examined by immunofluorescence, light and electron microscopy. The biopsy taken from the involved skin of one patient with leg ulcers revealed small blood vessel occlusions by cryoglobulin aggregates. Since a similar finding was not observed in the biopsy material taken from the other five patients who had no ulcerative skin lesions, it seems that the cryoglobulin aggregates play a role in the development of the skin ulcerations in primary mixed IgM-IgG cryoglobulinemia.

Adult↗
PubMed1982

Relapsing polychondritis associated with mixed cryoglobulinemia.

The case of a patient with mixed-type cryoglobulinemia and cutaneous necrotizing vasculitis, who later suffered from relapsing polychondritis affecting the auricle and the nose, is described. To the best of our knowledge, this combination is unique.

Adrenal Cortex Hormones↗