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Biomedical subjects

M Ben Moussa

Publications and source records attributed to M Ben Moussa.

18 recordsLinked to original sources
PubMed2006

[Cytomegalovirus myelitis in immunocompetent adult].

INTRODUCTION: Cytomegalovirus (CMV) infection occurs in 40 to 100% of general population. It is often asymptomatic in immunocompetent subject but may induce neurological syndromes such as encephalitis and myelitis. CASE RECORD: We reported a case of a 64-years-old woman immunocompetent, with acute proximal upper and lower limb weakness, paresthesias and two episodes of urinary retention. MRI of the spine showed abnormal enhancement from cervical to lumbar spine indicative for myelitis. Diagnosis of CMV associated myelitis was confirmed by a positive CMV serology. Administration of ganciclovir was followed by a partial improvement in five months. DISCUSSION: Few cases of CMV acute myelitis in immunocompetent patients have been reported in the literature. The pathogenesis is not well known, however, immune-mediated central nervous system damage may be attributed to the pathogenesis of the disease. Early diagnosis and treatment improves the prognosis.

Antiviral Agents↗
PubMed1994

[The nucleolus organizer region (Ag NORS) in urothelial tumors. Apropos of 10 cases].

The authors study nucleolar organisers (Ag NORS) in ten cases of urothelial tumours, graded as grade I in five cases, grade II in two cases, grade III in two cases and intermediate grade II-III in one case. Study of the NOR index showed a mean value of 3.89 for grade I, 4.66 for grade II, 5.88 for grade III and 4.90 for the intermediate grade II-III. Different values were recorded in the same heterogeneous tumours containing tumour zones of different grades, providing an additional argument in favour of the heterogeneity of these urothelial tumours and accounting for the difficulties of their classification reported in the literature. Adequate sampling should allow a more objective and more representative study of all of the tumours examined.

Humans↗
PubMed1992

[A case of bladder pheochromocytoma].

Phaeochromocytoma is an endocrine neuroectodermal tumour usually located in the adrenal gland, but occasionally arising in other organs. The authors report a case of a vesical phaeochromocytoma presenting with haematuria. Radiological and endoscopic investigations revealed a right laterovesical submucosal tumour. Partial cystectomy was performed. The normality of the postoperative endocrine survey suggested disappearance of the tumour and absence of any other sites.

Adult↗
PubMed1982

[Meso-omental cystic lymphoma. Considerations apropos of 4 cases].

Cystic meso-omental lymphangiomas are uncommon benign tumors. When symptoms arise, the correct diagnosis is only exceptionally considered. These tumors may be revealed by a variety of clinical pictures which, in fact, are not specific. Cystic meso-omental lymphangiomas are usually diagnosed in pediatric patients, although they may arise in adults. The four patients who are reported on are adults. Diagnosis was established upon histopathological examination of specimens removed during surgery or autopsy. Data from a review of the medical literature provides a basis for a clinical and above all pathological study of cystic meso-omental lymphangiomas. Prognosis is usually favorable although it is dependent upon the conditions of surgical management.

Adult↗
PubMedDate not supplied

[Comparison of two hepatitis C virus typing assays in a Tunisian population].

In patients with hepatitis C, it is necessary to determine the genotype of the hepatitis C virus (HCV) to tailor treatment schedules. HCV-positive sera from 60 chronically infected patients were analyzed by two methods: serotyping and genotyping, to evaluate the suitability of serotyping method for routine determination of HCV genotype; 47 men and 13 women were included in this study, nine were renal transplant patients and five were hemodialysis patients. Anti-HCV antibodies were detected by Elisa (HCV Ab III, Innogenetics SA) and confirmed by immunoblot assay (INNO-LIA-HCV Ab III update, Innogenetics SA). Genotyping analysis was performed by a line probe assay (Inno-LiPA-HCV, Innogenetics SA) and serotypes were determined by an Elisa-based serotyping assay (Murex HCV serotyping 1-6 HCO2, Murex SA) which detect type specific antibodies against NS4-derived epitopes. Among 60 patients positive for anti-HCV antibodies and confirmed by immunoblot assay only 90% show a strong reactivity with NS4. We found the following genotype distribution : 1b (73.3%), 4 (10%), 1a (5%), 3a (5%), 4c/4d (5%) and 1 not classified (1.7%). The most prevalent serotype was type 1 (60%) followed by serotype 6 (20%), 4 (8.3%), 2 (1.7%) and 10% were no type specific antibodies. The sensitivity of the serotyping and the genotyping assays was 90% with a total concordance of 68.3%. Thirteen samples revealed discrepant results with genotype : 1b (4), 1a (3), 3a (3), 4 (2) and 4c/4d (1). This study indicates that the serotyping assay is less specific than genotyping. However, the test is rapid, relatively easy to perform and represent a reliable alternative in laboratories that lack the specific expertise to typing the HCV by molecular methods.

Adolescent↗