Search PubMed⌕ Search

Biomedical subjects

M Beck

Publications and source records attributed to M Beck.

At least 325 records · Page 18Linked to original sources
PubMed1983

Effect of percentage cut-off scores and scale point variation on preclinical project evaluation.

Several modifications were introduced in a criterion-referenced evaluation system to determine which modification would result in optimal evaluator reliability and performance differentiation on two representative wax-up projects. Variables investigated included the use of percentages as cut-off scores and the number of scoring options. The use of percentage cut-off scores to define minimal competency significantly increased intrajudge reliability for one of the two projects. Two-option scoring resulted in significantly higher rater agreement than three-option scoring in half of the comparisons.

Clinical Competence↗
PubMed1982

Antiviral and anti-invasive titers of human interferons.

The titers of preparations of human leukocyte and human fibroblast interferon were examined to determine their antiviral and anti-invasive activity. The examinations showed a very high correlation of these activities in human fibroblast interferon (r = 0.99), whereas the correlation for human leukocyte interferon was lower. These two interferons have also been found to differ in the relation between antiviral and anti-invasive titers. This difference is highly significant (p less than 0.001).

Humans↗
PubMed1981

Interferon treatment of uterine cervical precancerosis.

Human leukocyte interferon (HLI) was used in a randomized study of patients with precancerous states on the uterine cervix. The daily dose of HLI was 10(6) units and its was applied by the contraceptive pessary technique. In patients how had had only viral alterations on the cervix the treatment lasted 14 days (Singer et al. 1979) and in those with changed cytologic findings 21 days. The cytologic findings of the interferon treated patients showed no progression of the pathologic process during the ensuing 2 years. In the control group, however, they showed the aggravation of the process and the patients were directed to surgical therapy. The control of cytologic findings has been continued and in now performed at 3 month intervals.

Female↗
PubMed1981

[The tissue adhesion of the ruptured spleen with highly concentrated human fibrinogen (author's transl)].

After splenectomy the immunologic impairment and the susceptibility to infection is increased, but the most important impetus for splenic preservation has been the observation of the overwhelming postsplenectomy sepsis. Successful results with surgical repair of traumatized spleen and several different techniques have been reported. Instead of suture of splenorrhaphy we used in our experiences a new biological adhesive-system, consisting in thrombin, highly concentrated native human fibrinogen and clotting factor XIII. The highly adhesive properties, the excellent tissue compatibility and the haemostyptic effects recommend this system for using in preservation of the injured spleen as well as possible.

Adolescent↗
PubMed1981

Cytological and biochemical methods for the characterization of in vitro cultured cells.

The aim of our presentation was to show how we characterize cells cultured in monolayer system. Cytological and biochemical methods were used. Ovarian Krukenberg tumour fibroblasts were investigated and findings were correlated with normal human diploids (HDZ1) and with fibroblasts obtained from Blighted ovum. Cytomorphologically Malignancy associated changes in the tumour fibroblasts were found. Cytochemically acid phosphatase and alpha-naphtyl-esterase were positive (+++). PAS reaction was doubled in 18th passage. Cytogenetically normal human diploids were found. Biochemically enzymatic assay showed phosphopentose shunt is decreased in tumour fibroblasts and alpha-glucosidase and beta-galactosidase activities were significantly lower in these cells. A form of N-acetyl-beta-glucosaminidase fell during the investigation from normal 75% to lower percent (42% of the total activity). Much more parameters were obtained by different methods and Krukenberg tumour fibroblasts may be better understood. In vitro investigation makes a contribution to biomedical knowledge in cancer research.

Enzymes↗
PubMed1981

Parallel worlds.

Explore the source record for details and available documents.

Adolescent↗
PubMed1981

Assessment of the retinal toxicity of hydroxychloroquine.

A survey of 347 patients on treatment with hydroxychloroquine showed that a mild pigmentary maculopathy was present in 29 per cent of cases if a cumulative dose of more than 800 g of the drug had been ingested. Most of the affected patients showed no deterioration in visual function. The significance of these findings is discussed with particular regard to the screening of patients on hydroxychloroquine therapy.

Adult↗
PubMed1977

Normal sugar uptake in vitro by small-bowel biopsies from a patient with cholera.

We have investigated the 3-O-methyl-D-glucose (3MG) absorption by jejunal biopsies obtained from a patient with cholera. The absorption of 3MG (as measured from the determination of intracellular accumulation of this sugar) was found to occur against a concentration gradient and to be a saturable process that follows Michaelis-Menten kinetics. There was no appreciable difference in 3MG absorption between the biopsies from the normal volunteers and those from the patient with cholera.

Adult↗
PubMed1977

[Spontaneous aortic dissection. Diagnostic experience with 32 patients].

Of 48 patients in whom angiography was carried out on the clinical suspicion of spontaneous aortic dissection, the diagnosis could be confirmed in 18 cases only. On the other hand, aortic dissection was discovered incidentally in 14 patients on whom angiography was being carried out for other reasons. The high incidence of incorrect diagnosis is due to the variety of clinical symptoms caused by various types of dissection combined with the non-specific radiological findings on chest radiographs. Unlike plain films, aortography, provided a suitable technique is employed with an understanding of the possible sources of error, gives a high degree of diagnostic certainty with little risk. It is therefore always indicated when the demonstration or exclusion of an aortic dissection is likely to influence treatment.

Adult↗