Search PubMed⌕ Search

Biomedical subjects

M Beaugrand

Publications and source records attributed to M Beaugrand.

At least 127 records · Page 7Linked to original sources
PubMed1985

[Hepatocellular carcinoma and the alpha 1-antitrypsin phenotype].

To determine whether or not alpha 1-antitrypsin phenotype PiMZ is a predisposing factor for hepatocellular carcinoma alpha 1-antitrypsin phenotype was studied in 83 French patients with hepatocellular carcinoma compared with 1,030 blood donors. In 66 patients, alpha 1-antitrypsin phenotype was determined by isoelectric focusing which allows the distinction between subtypes of phenotype M. No difference has been shown between the two groups for alpha 1-antitrypsin alleles or subtypes of allele Pi*M. The authors conclude that phenotype PiMZ is not a significant predisposing factor for hepatocellular carcinoma in French people. As well, a review of literature suggests that, in contrast with the conclusion of previous reports, the link between alpha 1-antitrypsin phenotype PiMZ and hepatocellular carcinoma is either nonexistent or very weak.

Carcinoma, Hepatocellular↗
PubMed1983

[Fatal herpetic hepatitis in an apparently healthy adult].

The authors report the case of a 46-year old patient who died from fulminant herpetic hepatitis. No cause of immuno-depression was documented in this patient. No skin or mucosal herpetic lesion was found except a questionable urethritis. Herpes virus was demonstrated in the hepatocytes by electron microscopy and isolated from the serum. It was identified as herpes virus hominis type II. The low titer of circulating antibodies did not permit the distinction between herpetic primo-infection and reactivation. The features of the hepatic injury are discussed and compared with previous reports. An active diagnostic approach of herpetic hepatitis is considered.

Acute Disease↗
PubMed1983

[Do latent bacteremia and endotoxinemia exist in cirrhotics? A study of 48 patients].

Forty-eight patients with alcoholic cirrhosis and absence of patent infection were assessed for asymptomatic bacteriemia and endotoxemia. 280 blood cultures have been performed and 190 serum samples collected for study by two different methods of the limulus test (LT). Bacteriemia was found in 7 blood cultures from 3 patients. In these patients, occult infection was demonstrated in each case (cholecystitis, ulcerated rectal adenocarcinoma, cutaneous infection). Sixteen LT from 14 patients were positive initially. Only one LT remained positive after control by two different methods. These results suggest that in patients with alcoholic cirrhosis and in the absence of patent infection: 1) bacteriemia is an infrequent feature and, if present, explained by other causes than cirrhosis. 2) LT is negative in systemic blood when rigorous controls are performed, and endotoxemia cannot be substantiated by this test.

Adult↗
PubMed1981

[Search of a cytomegalovirus infection during pseudo-membranous colitis. 6 cases (author's transl)].

Six patients with pseudomembranous colitis unrelated to lincomycin or clindamycin treatment were investigated for signs of localised or diffuse cytomegalovirus (CMV) infection. Before the onset of colitis 3 patients had receive prednisone, associated in 2 of them with immunosuppressive drugs. Testing for CMV included rectal mucosa biopsies, culture of blood leucocytes with human embryo diploid fibroblasts in continuous layer and titration of complement-deviating anti-CMV antibodies. Cytomegalic cells with nuclear inclusion bodies were found in the rectal mucosa of 5 patients, 4 of whom also had foci of CMV-infected cells in leucocyte-fibroblast cultures, indicative of viraemia. The fifth patient was not tested for viraemia but developed very high anti-CMV antibodies titers at a later stage. These results show that pseudomembranous colitis that are not due to antibiotics are frequently associated with localised or diffuse CMV infection. Viral invasion of the colon might be encouraged by a state of immunodeficiency.

Adult↗
PubMed1981

[Liver aspiration biopsy with a disposable instrument: Hepafix (author's transl)].

Liver aspiration biopsies performed with a new disposable instrument (Hepafix) were compared with biopsies performed with the conventional Menghini's needle in 74 patients. The diameter of the needle was the same in both groups, being either 1,4 or 1,6 mm depending upon the case. Twenty-seven of the 39 patients (69,2%) biopsied with the new instrument experienced no pain during puncture, as opposed to only 9 of the 35 patients (25,7%) biopsied with the standard needle. In non-cirrhotic patients, tissue fragments were longer with Hepafix (mean, 40 mm) than with Menghini's needle (mean, 25 mm). The authors' preference goes to Hepafix because it is less painful, responsibly cheap and carries no risk of viral contamination.

Biopsy, Needle↗
PubMed1981

[Radiological, fibroscopical, histological and secretory gastric aspects in hemodialyzed patients (author's transl)].

Seventeen chronic hemodialyzed patients underwent a baryum meal, a fibroscopy with biopsic studies and an evaluation of gastric acid secretion. No duodenal ulcer was found. The gastric and duodenal folds are the most common anomaly. It has been not possible to correlate these folds to a precise histological entity. None of these patients exhibited an hypersecretory state, on the other hand 3 of them were hyposecreting. A statistical relationship between BAO on the one hand and PTH, CT and Ca on the other hand was found.

Adult↗