Comparative studies on the mutagenicity of pirenzepine with submammalian/bacterial and mammalian systems.
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Animals↗
Biomedical subjects
M Baumeister
Publications and source records attributed to M Baumeister.
Detection of the carcinogenic nitrofuran derivative VR-6 as a mutagen in the Salmonella/microsome test.
The carcinogenic nitrofuran, VR-6, was evaluated for mutagenicity in Salmonella typhimurium TA 100 using the plate assay (Ames test). The dose-response curve indicated that S. typhimurium TA 100 is a very sensitive genetic indicator for this chemical class and that basepair substitution appears to be the molecular mechanism with VR-6. The results reported here provide evidence, that VR-6 is a directly acting mutagen for S. typhimurium TA 100 and that the chemical is partially deactivated in the presence of rat liver homogenates. Comparison of the results obtained with this agent in the Ames test with data from a subacute animal study, showed a good agreement in predicting the carcinogenic risk.
Animals↗
[Influencing the water solubility of caffeine. Influence of sodium salts on aliphatic acids].
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Amino Acids↗
Heats of reaction and stability of caffeine complexes.
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Caffeine↗
[Contribution to the effects and use of Rompun in cattle].
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Analgesics↗
Confocal microscopic imaging of reticular folds in a laser in situ keratomileusis flap.
PURPOSE: To report the clinical and confocal microscopic characteristics of reticular folds (mudcracks) in a cornea after laser in situ keratomileusis (LASIK). METHODS: A 30-year-old male showed reticular flap folds on slit-lamp examination 1 week after LASIK. In addition to slit-lamp biomicroscopy, confocal in vivo microscopy was performed. RESULTS: Examination with a confocal white-light slit-scanning microscope revealed distinct folds of Bowman's layer and underlying microfolds throughout the flap stroma. After flap re-lifting, no changes could be determined, either clinically or by confocal microscopy. At 12 months following the procedure, best spectacle-corrected visual acuity was slightly improved, but the folds, as imaged by confocal microscopy, still persisted. CONCLUSIONS: In the present case, reticular folds after LASIK involved the entire thickness of the flap. Simple flap lifting was not sufficient for smoothing out the folds.
Adult↗