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Biomedical subjects

M Bartolo

Publications and source records attributed to M Bartolo.

At least 37 records · Page 2Linked to original sources
PubMed1987

Results of clinical, laboratory and haemorheological investigations of the use of pentoxifylline in high doses.

A study was carried out in 127 patients (94 males and 33 females) presenting with arteriosclerosis (88 patients) or diabetic vasculopathy (39 patients) in different stages of severity (Fontaine) to assess the effectiveness and tolerance of treatment with high doses of pentoxifylline. Patients received a daily dosage of 2200 mg, given as 800 mg orally and 300 mg by intravenous infusion in saline twice daily, for a mean period of 15.8 days. Relevant clinical parameters were assessed and measurements made of biological and laboratory indices before and after treatment. The results showed that intermittent claudication was improved in 52.4% of the arteriosclerotic and 50% of the diabetic patients Stage II disease, pain at rest disappeared in 64% and 78% of patients in Stage III, respectively, and trophic lesions in Stage IV patients were reduced or became less clearly marked in 47% and 44%, respectively. Arterial blood pressure, recorded on the tibial arteries using Doppler ultrasound, showed a mean increase of 18%, but no significant changes in blood flow were evident from rheographic examination. Whole blood erythrocyte filtration time was reduced by a mean of 8%. The main changes in the biological indices after treatment were decreases in haematocrit, mean corpuscular volume and blood fibrinogen values, but these were not statistically significant. The other variables showed little if any change. Side-effects initially reported by the patients consisted of headache, nausea, sweating, pruritus and general malaise, and were mainly associated with the infusion time and regressed in most cases when this was extended.

Aged↗
PubMed1986

[Epidemiology of vascular diseases in Italy].

The mortality rate from cardiovascular diseases was analysed for Italy as a whole and for individual regions in a sample year (1975). A distinction was made between cardiac and vascular diseases in order to assess the real incidence of the latter. The absolute number of deaths, the percentage mortality and the specific mortality quotient were studied. Deaths were also divided into age groups. Cardiovascular diseases were found to be the primary cause of death, circulatory disease the second. Among the latter, diseases of the encephalic circulation took first place. The same parameters were applied to the 1965-1983 period. Mortality due to cardiovascular disease remained constant over the period since the decrease in deaths from cardiac conditions was offset by an increase in those due to vascular disease in the strict sense. Finally the specific standardised mortality quotients per age and sex were considered in the 1970-1979 period. Mortality trends in Italy and in the individual regions were identical to those described using non-standardised indices.

Age Factors↗
PubMed1985

Clinical-instrumental relationships in post-phlebitic syndrome.

981 lower limbs belonging to 829 subjects, 67.6% of which were females, have been examined. The average venous pressure at the tibial posterior vein was 101 +/- 12 mmHg and 102 +/- 13 mmHg on the internal saphenous vein. In 311 lower limbs with femoro-iliac thrombosis, venous pressures are slightly higher than in 670 lower limbs with calf veins occlusion. In the 44.4% of cases the phlebothrombosis was clearly dependent on traumas, deliveries, surgical operations or other conditions. The relationships between the supposed aetiopathogenesis of the affection and the pressure values have been examined. The 6.7% refers to phlebitis, which caused pulmonary embolism during their acute phase. The different objective and subjective symptoms have, furthermore, been taken into consideration. It has been noticed by the analysis of the diagrams of the pressure values in the time that the same values which are considerably high at the initial phase of the iliac postphlebitic syndrome, are always high in the following years. On the other hand, in postphlebitic syndrome of the leg those pressures whose value are not remarkably high in the initial phase, increase from the second to the fourth year after the arising of phlebitis and, finally become stable at fairly high values, but still lower than those of iliac syndrome. The venous orthostatic pressure of internal saphenous vein in the iliac postphlebitic syndrome was also found to exceed the deep pressures, likely because of the altered saphenous discharge at the cross level.

Adult↗
PubMed1985

Instrumental evaluation of the venous circulation in the arteriopathic subjects.

In peripheric arteriopathies, alterations occur to the venous system with a particular swelling of the veins of the foot-top, in the subjects (sclerotic or diabetic) at the 2nd and 3rd Fontaine stage, which gradually decreases until the collapse in the most advanced levels of the arterious affection (4th stage). In order to verify all that, we examined 40 artheriopathic subjects at the different Fontaine stages through a c.w. doppler apparatus and an impedence plethysmograph. Together with the modification of the arterious doppler velocitogram and the reduction of the Winsor index, we noticed that the velocity of the venous flow increases together with a venous hypertension that reaching the highest values at the 3rd stage, while at the 4th stage they are reduced because of the progress of the sclerosis. The impedence plethysmogram shows a reduction of the systodiastolic sphygmic excursion with a variation of the basic line, depending on the respiration, proportional at the clinic stage. In diabetic subjects the progress of the disease is more precocious because of the quicker implication of the microcirculation.

Aged↗
PubMed1985

[Hemodilution, defibrinogenation and plasmapheresis in hemorheology].

Blood and plasma viscosity can be influenced by various therapeutic procedures: among these, that of hemodilution stands out. This can be hypovolemic, normovolemic or hypervolemic; it is hypovolemic if blood subtraction is not followed by a liquid reintroduction, it is normovolemic or hypervolemic if there is a liquid reintroduction of the same or higher quantity than the subtracted blood mass. This method has been considered very favorably by surgery in order to save blood for transfusions. Hypervolemic hemodilution can also be carried out without blood subtraction; a report on this method shows good clinical results and positive hematochemical and hemodynamic effects obtained on 93 peripheral vasculopathic patients at stages III and IV of the Fontaine classification. Plasmapheresis, which would be best called plasma-exchange, consists in the removal of that part of the patient's plasma containing abnormal proteins, immune complexes or toxins, and in its substitution by other colloids or crystalloids. Defibrinogenation is not much employed in Italy, as the most effective drugs, such as ancrod and batroxobin are not available in this country. The good results reported were transitory, due to the rapid appearance of antibodies which can inhibit the effects of these drugs. Nevertheless, there also exist minor fibrinogenolytic drugs.

Ancrod↗
PubMed1983

[Contribution to the recognition of Mondor's phlebitis].

The AA. have carried out a complete review of the world literature on Mondor phlebitis of the last 50 years (214 cases) pointing out the clinic and epidemiologic characteristics and those of a possible aetiogenesis. 11 personal cases, detailed characteristics of which are given, have been presented. The female sex is the most affected (63,3%) and the most frequent aetiopatogenetic factors are: accidental or surgical traumas (35,7%), muscular stresses (6,3%, centres of infection (4,3%, concomitant mammary pathology (2,4%). The most common symptom is pain (51%) with or without tension sensation (28,9%). The histologic aspect relevant to the biopsy, shows the characteristics of thrombophlebitis non specific, almost always without periphlebitis. The cases presented by the AA. are characterized by the high incidence of relapses (45,4% against 5% of the total cases in the world) as well as by the occasional positivity of the specific serum-agglutination for the Rickettsia Q18 (2 cases out of 11) and the reduction of some immunologic tests (1 cases out of 11). This latter data are leading to two aetiopatogenetic hypothesis: the infective and immunitary one.

Breast↗
PubMed1982

[Possible rickettsial etiology of Buerger's disease].

We have established a serologic study with method of direct microagglutination described by Babudieri and Zardi, by 31 patients affected from a Buerger's disease, to determine the positivity of antibody title which desposes on rickettsiosis infection. Positivities have been confirmed for the Rickettsia Burnetii from 41,9% of cases, for R. Mooseri from 6,4% and for the R. Conori only from one case. Since the positivity varies in the normal population from the 0.7% to 1.1% the data related appears very significant for a possible rickettsiosis etiology of the Buerger's disease.

Adolescent↗
PubMed1982

[On some experimental conditions possibly influencing the correct measurement of venous pressure by Doppler method].

Measurement of venous pressure by means of the Doppler method applied to the posterior tibial vein and to the internal and external saphenous veins is subject to error which depends on the observer's technique. We have therefore sought to ascertain whether and how differences in measurement techniques could affect the results of venous pressure determination in 50 subjects. We have observed that: --Measured pressure are higher when the duration of the test is prolonged, probably because the cuff remains inflated too long. --Of several consecutive determinations, the first and second yield generally higher values, that decrease and remain stable thereafter through the 5th measurement, following the initial loss of venous tone. --Venous pressure is lower as the measurement site is moved more proximally, as predicted by the expected pressure gradient along the venous circulation; the decrease could also be affected by local changes of vein compliance.

Adult↗
PubMed1981

[Correlations between clinical stage and peripheral pressures in peripheral vascular diseases (author's transl)].

The authors have studied 311 patients with arterial occlusive disease of the lower limbs. They have taken the arm pressure and the ankle pressure (A.P.) and have calculated the ankle/arm pressure index of Winsor (I.W.) in order to ascertain a relationship between peripheral pressure and clinical stage. The result is that both I.W. and A.P. are equally valuable to depict the different stages of the arterial occlusive disease.

Aged↗