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Biomedical subjects

M Barthels

Publications and source records attributed to M Barthels.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Behavior of factor VIII associated antigen in thrombophilic states].

In several diseases the factor VIII: Ag in the plasma of patients increases extremely in some cases, while the other subunits of the factor VIII molecule increase moderately. Only in very few cases these findings might be the expression of a thrombin-induced alteration of the factor VIII molecule. Determination of factor VIII: Ag in vascular diseases is of comparatively high clinical relevance, since in this case a high factor VIII: Ag level may be indicative of endothelial lesion, if other influences can be ruled out.

Antigens↗
PubMed1984

[Superficial purpura with necrosis in severe consumptive coagulopathy. Clinical study].

In this report the case history of three patients with superficial, non-inflammatory purpura is described. In all patients the purpura demonstrated partially reticular, partially racemose configuration. Signs of disseminated intravascular coagulation were detected in two patients. One patient developed disseminated intravascular coagulation caused by an overwhelming postsplenectomy infection. Nosological position, pathogenesis and differential diagnosis of this kind of purpura are discussed.

Adolescent↗
PubMed1982

[Preprothrombin in acute viral hepatitis B].

In vitamin K deficiency or treatment with vitamin K antagonists, a precoagulant of prothrombin (Factor II) called preprothrombin has been established. We measured preprothrombin with Clarke-Freeman electrophoresis in 26 patients with acute viral hepatitis (21 HBS-AG positive) who did not suffer from vitamin K deficiency. Prothrombin and the vitamin-K dependent Factors VII, IX, and X were determined by standard coagulometric methods. Prothrombin was additionally estimated by immunoelectrophoresis according to Laurell. Three patients with acute HBS-AG positive hepatitis showed preprothrombin in their plasma. The activity of Factors II, VII, IX, and X was slightly below normal with normal concentration of Factor II in the immunoelectrophoresis. Liver parenchymal damage and cholestasis were slight; the pseudocholinesterase showed subnormal levels in all three patients. Possible causes for the appearance of preprothrombin in the peripheral blood in acute viral hepatitis and the possible connections with liver cell damage are discussed.

Acute Disease↗
PubMed1982

Additional factor XII (Hageman factor) deficiency in hemophilia A and in von Willebrand syndrome.

Factor XII plasma levels were investigated with several methods in patients with hemophilia A and B and von Willebrand syndrome. There seem to be some families with hemophilia A or von Willebrand syndrome, who have an additional, congenital, partial lack of factor XII (Hageman factor). The mode of inheritance is independent of the other coagulation disorder. Frequently, the first indication of an additional factor XII deficiency is the disproportionate prolongation of the activated partial thromboplastin time (PTT) as regards the factor VIII level. The average factor XII level in patients with hemophilia A and von Willebrand syndrome is significantly lower than in normal subjects or patients with hemophilia B. It cannot be excluded that the frequently low levels of factor XII in patients with severe hemophilia are acquired and probably due to liver cell damage.

Adolescent↗
PubMed1979

Coagulation and fibrinolysis in multiple trauma after early heparinizing.

In 27 multiple trauma patients receiving standard shock management and intensive care, coagulation and fibrinolysis were investigated after early heparinization. The general coagulation tests did not imply any impaired clotting function. Platelets and factors I, II, and V decreased without induction of hypocoagulability. There was considerable decrease in plasminogen, whereas FDP ranged within normal; thus, a hyperplasminemia can be excluded. Antithrombin III remained within normal range; even in nonsurvivors there was no depletion, although their antithrombin III activity was significantly lower. In comparison to 50 trauma patients - a comparable group with regard to trauma patterns, shock management, and intensive care - there were no significant differences in volume requirements or mortality rate. Whether early heparinization is effective in preventing disseminated intravascular coagulation (DIC) related organ failure remains to be seen.

Adult↗
PubMed1979

[Correlations between the diminished secretion of export proteins from the liver and the plasmatic activity of liver cell enzymes (author's transl)].

For the evaluation of certain differences in the diminution of export proteins of the liver we examined some exactly defined groups of liver diseases with the aim of further differentiation of the pathogenetic mechanisms. We measured the activity of glutamate-oxalacetate transaminase, glutamate-pyruvate transaminase, glutamate dehydrogenase, lactate dehydrogenase, alkaline phosphatase, cholinesterase and lecithin-cholesterol acyltransferase, the Quick value, the coagulation factors I, II, V, VII, VIII, IX and X. Clotting factors were determined by a Schnitger-Gross Coagulometer. Prothrombin, antithrombin III, plasminogen, factor VIII associated antigen and activated factor XIII were measured by immunoelectrophoresis according to Laurell. Lipoprotein electrophoresis in agarose gel was performed to evaluate changes in lecithin-cholesterol acyltransferase activity. Except of the rising diminution of export proteins in the course of liver disease from acute hepatitis to cirrhosis we found also specific changes of the patterns of the plasma specific enzymes. These proteins were diminished dependent on their half life time and the inflammatory activity--measured as the height of the transaminases. Lecithin cholesterol acyltransferase and factor VIII did not participate in the general diminution of the most export proteins; some details were found to explain this differing behaviour. Results are critically discussed with regard to new aspects in the biochemistry of the damaged liver cell.

Acyltransferases↗
PubMed1978

[In vitro evaluation of adsorbents used in haemoperfusion (author's transl)].

The properties of six adsorbents for Haemoperfusion were investigated in vitro: Amberlite XAD-2; Amberlite XAD-4; Haemocol; collodion coated charcoal; albumine-collodion encapsulated charcoal and activated carbon fibers. Carbromal and diazepam are most quickly removed from aqueous solutions by Amberlite XAD-2 and XAD-4. Of the charcoal containing materials, Haemocol eliminates most rapidly carbromal and diazepam; while activated carbon fibers remove phenobarbital faster. When heparinized blood is perfused, a remarkable reduction in platelet count is observed. The drop is most pronounced with Amberlite XAD-2 and XAD-4, but even when using charcoal preparations the platelet depletion can reach 10% of the original number over 5 hours. Haemolysis is most pronounced with Amberlite XAD-2, XAD-4 and Haemocol. As the efficiency of the adsorbents towards the various drugs differ and as their adverse effects also vary, the decision for a particular material will have to be made according to the individual case.

Adsorption↗
PubMed1978

[Coagulation factors and thrombocytes after application of Reptilase in the course of gynecologic operations (author's transl)].

Hemostasiologic effects of intravenous application of Reptilase were investigated in a randomized double blind study in the course of normal abdominal and vaginal hysterectomies. Coagulation factors and thrombocytes were checked before, after, 40 minutes after as well as 24 hours after the operation. Significant shortening of the clot observation time resulted 40 minutes after the injection of 1 ml Reptilase. A small but highly significant decrease of thrombocytes was observed 40 minutes after the end of the operation when Reptilase was injected. Further coagulation screening tests: Quick test, PTT and thrombin time were without statistically differences in both patients groups from the beginning till 24 hours after the operation. A significant decrease in Factor V concentrations resulted 40 minutes after the injection of Reptilase, whereas no changes were seen in the placebo patient group. Too, Factor XIII values and Antithrombin 3 concentrations decreased after the administration of Reptilase. There was no abnormal raise of fibrin-monomers in both groups. Enhanced fibrinolysis with elevated FDP-levels were measured in none of the cases. The administration of Reptilase induced a short lasting augmentation of blood coagulation but without any signs of disseminated intravascular coagulation.

Adult↗
PubMed1978

[Twin pregnancy in a patient with Glanzmann disease (congenital thrombasthenia) (author's transl)].

Report on a 30-year old primigravida with a family history of bleeding and a personal history of nasopharyngeal bleeding since age four. Severe menorrhagia since her menarche. First seen at 20 weeks gestation with naso-pharyngeal bleeding and a twin pregnancy. The patient was found to have Glanzmann's disease (congenital thrombasthenia) with an excessive lack of factor XIII. Ambulatory treatment with packed cell transfusions until 35 weeks gestation. The thrombelastogram did not improve with transfusions of platelet concentrates. In-patient treatment from 35 to 37 weeks gestation, no vaginal bleeding throughout the pregnancy. Elective Caesarean hysterectomy at 37 weeks gestation with lo units fresh blood, 3 units platelet concentrate and 10 ampules factor XIII concentrate in readiness. Delivery of twin girls 3180 and 3050 g without signs of Glanzmann's disease. Treatment of the maternal bleeding by replacement. Factor XIII 80% of normal 8 weeks postpartum. This appears to be the first case of twin pregnancy in the presence of Glanzmann's disease and the fourth case in the world literature.

Adult↗
PubMed1977

[Studies on the effect of thrombocytopenia on the rate of fibrin stabilization].

Severe thrombozytopenia, and therefore a lack of phospholipids, delays not only the thrombin formation rate but also, because of retarded factor XIII activation the fibrin stabilizing process. The other clotting factors, especially factor XIII, being within the normal range, this effect is only noted when the platelet count drops below 30 000/mm3.

Factor VIII↗
PubMed1977

[Fibrinogen "Hannover", a further abnormal fibrinogen].

Another abnormal fibrinogen--"fibrinogen Hannover"--is reported. As known from most dysfibrinogenemias the clottability is poor, while immunologic test, heat precipitating test and the staphylococcal clumping test give normal fibrinogen concentrations. The clotting time when using thrombin or thrombin like enzymes is prolonged, it can be corrected with high thrombin concentration or thrombin combined with calcium inons, but not with thrombin like enzymes combined with calcium ions. The mild bleeding diathesis was first noted when the patient underwent an operation.

Adult↗
PubMed1975

[Joint bleeding in haemophiliacs receiving substitution treatment as out-patients (author's transl)].

15 patients with severe haemophilia A recorded the rate and course of acute joint bleedings during one year. The episodes treated by replacement were compared with those not so treated. From the results it is evident, that treatment with factor VIII concentrates (n equal 8) alone does not completely prevent haemophilic arthropathy, but may reduce it in the individual cases to a level where it only occurs with higher bleeding rates. The bleeding rate depends mainly on the stage of the arthropathy. There is significant improvement of joint movement and significant regression of joint circumference after infusion treatment. Acute joint bleedings in haemophiliacs can be successfully treated by a combination of haemostatic and anti-inflammatory substances, as well as by physiotherapy and orthopaedic means.

Adolescent↗