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Biomedical subjects

M Bartels

Publications and source records attributed to M Bartels.

107 records · Page 6Linked to original sources
PubMed1983

Computerized tomography in tardive dyskinesia. Evidence of structural abnormalities in the basal ganglia system.

Twenty-nine patients with moderate to severe tardive dyskinesia (TD) and 29 age- and sex-matched controls (C) with long-term neuroleptic therapy comparable to that of the patients were all examined using computerized tomography. Significant differences were found between the two groups in the width of the third ventricle (TD greater than C), the bicaudate distance (TD greater than C), the computed area of the head of the caudate nucleus (TD less than C), and the area of the lenticular nucleus (TD less than C). No significant differences were established in the ventricular or cella media indices. These results suggest that structural abnormalities, primarily in the basal ganglia system, are present in TD patients. Psychological testing with the Benton visual retention test also showed significant differences with regard to cerebro-organic functional impairment among TD patients.

Adult↗
PubMed1983

[Transitory cerebellar ataxia from high dosage combination thymoleptic therapy].

Transitory ataxias have repeatedly been observed and reported in connection with antidepressant medication. However, it is remarkable that exact descriptions of this particular form of ataxia are rarely included. Also, hypotheses concerning the etiology and pathophysiology of these disorders are generally lacking. They are usually given the imprecise designation of "extrapyramidal" ataxias. Two cases are presented here in which therapy-resistant endogenous depressions were treated with maprotiline/dibenzepine and maprotiline/clomipramine, respectively. In both cases, marked neurological side effects in the form of cerebellar ataxia developed. The symptoms, which occurred despite usual dosage, remitted after maprotiline treatment was discontinued for one patient and after dose reduction of both drugs for the other. The atactical and dysmetric symptoms described here are thought to result from a reversible intoxication of mainly cerebellar structures. In an attempt to explain the genesis of these ataxias, a neurophysiological and a neuropharmacological hypothesis are considered and predisposing factors as well as therapeutic consequences are discussed.

Aged↗
PubMed1981

Acathisia-syndrome: involvement of noradrenergic mechanisms.

The involvement of noradrenergic mechanisms in patients suffering from acathisia was investigated by determination of urinary night-time 3-methoxy-4-hydroxy-phenyl glycol (MHPG)-excretion and was compared both with control patients matched according to age and sex and healthy individuals. A significantly reduced MHPG excretion was found among the acathisia patients. It is suggested that a supersensitivity of the spinal noradrenergically innervated receptors caused by their long-term blocking is responsible for occurrence of the symptoms.

Adult↗
PubMed1979

[Long-lasting EEG abnormalities in alkylphosphat intoxication (author's transl)].

In the reported case of a severe alkylphosphate poisoning the first EEG-observation at the twentieth day after intake showed marked abnormalities although there was a complete physical and humoral recovery. Progressive normalization of the EEG occured in the following six weeks. Psychopathological symptoms of a mild apathy and slowening of reactions disappeared gradually.

Adult↗
PubMed1976

[Hemoperfusion by means of encapsuled charcoal for the treatment of exogenous and endogenous intoxications].

The method developed by Chang for using in collodion and albumin encapsuled charcoal as artificial cells for hemoperfusion has been studied in vitro. The capacity for the absorption of more or less dialysable exogenous substances (barbiturate, Diazepam, Parathion) and an endogenous toxic metabolite (p-hydroxyphenyl acetic acid) has been examined. With the absorption unit one can eliminate 80 to 90 per cent of the initial concentration of barbiturate, Diazepam and p-hydroxyphenyl acetic acid in about 90 min, of Parathion about 50 per cent in the same time, whereas bromide and ammonia are not absorbed. Attempts to avoid regional heparinisation by the incorporation of heparin into the capsule of charcoal granules were not successful. Assuming correct preparation of the hemoperfusion system, observance of steril precoutions and regional heparinisation, the use of the "detoxication shunt" is a promising means in the treatment of severe exogenous and endogenous intoxications which are not accessible by conventional therapeutic means.

Adsorption↗
PubMedDate not supplied

Is paranoid schizophrenia the most common subtype? Comparison of subtype diagnoses by Japanese and European psychiatrists, using the summaries of the same patients.

We compared the subtype diagnoses of schizophrenia (ICD-10) of 58 Japanese and 61 European psychiatrists matched for clinical experience using 10 case summaries. As a result, there are marked differences between Japanese and European psychiatrists in the mode of subtype diagnoses of schizophrenia rather than in the clinical pictures of the patients themselves; the hebephrenic type (F20.1) was more likely to be diagnosed by Japanese psychiatrists, while the paranoid type (F20.0) was more frequently diagnosed by European psychiatrists. Japanese psychiatrists take into account the patient's age at onset and the clinical course of the disease in identifying the subtype, while European psychiatrists tend to focus on the presenting symptoms, particularly paranoid symptoms.

Adolescent↗