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Biomedical subjects

M Barranco

Publications and source records attributed to M Barranco.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Relationship between Epstein-Barr virus and lymphoproliferative syndromes in patients without immunodeficiency].

PURPOSE: The relationship between Epstein-Barr virus (EBV) and infectious mononucleosis, pharyngeal carcinoma and Burkitt's lymphoma is well known. Further relationship seems to exist between EBV and the lymphoproliferative syndromes appearing in immunodeficient subjects. The present work is aimed to study the possible relationship between the virus and the lymphoproliferative syndromes presented by people without any apparent immunodeficiency. PATIENTS AND METHODS: The presence of antibodies against different antigens of the virus was analysed. Antibodies against the viral capsid antigen were studied along with those against the early antigen and the viral core antigen in 55 patients with lymphoproliferative syndromes, of whom 38 had non-Hodgkin's lymphoma and 17 had acute lymphoblastic leukaemia, and none of them had immunodeficiency. RESULTS: Significantly higher geometric means of the titres against capsid antigen and of the prevalence of antibodies against early antigen were seen in the patients with non-Hodgkin's lymphoma with respect to the control group. On the contrary, patients with acute lymphoblastic leukaemia showed lower immunologic response than the control group, although the difference was not significant for any of the antibodies under study. CONCLUSIONS: The higher immunologic response against EBV and its reactivation in non-Hodgkin's lymphoma would suggest that such agent could play a role favouring the onset of the disease, if not as a direct aetiological factor.

Adolescent↗
PubMed1992

[Rapid method for identifying Escherichia coli and species of the Proteeae tribe in urine].

BACKGROUND: To evaluate the possibility of using the determination of beta-glucuronidase and phenylalanine deaminase activity directly from urine samples for rapid detection (2 hours) of the presence of Escherichia coli and species of the Proteeae tribe. METHODS: To detect beta-glucuronidase activity methyl-umbelipheryl-beta-D-glucuronic was used as a substrate. The presence of fluorescence after incubation at 37 degrees C for 2 hours indicated a positive reaction. While phenylalanine was used as a substrate for detecting phenylalanine deaminase activity, FeCl3 was added after incubation at 37 degrees C for 2 hours with a greenish color being observed indicating phenylalanine deaminase activity. RESULTS: The detection of Escherichia coli by beta-glucuronidase activity presented sensitivity and specificity of 0.91 and 0.99, respectively. The positive predictive value was 0.96 and the negative predictive value was 0.98, whereas the determination of the phenylalanine deaminase activity with the aim of detecting species of the Proteeae tribe presented the following results; sensitivity 0.92, specificity 0.99, positive predictive value 0.94 and negative predictive value 0.99. CONCLUSIONS: The determination of beta-glucuronidase and phenylalanine deaminase activities directly from urine sediment has been demonstrated as a rapid and specific test for detecting the presence of Escherichia coli and species of the Proteeae tribe, therefore it must be considered as a useful test in early diagnosis of urinary infection thereby facilitating the administration of appropriate antibiotic treatment.

Amino Acid Oxidoreductases↗
PubMed1992

[Kidney retransplantation: prognostic factors in a series of 84 cases].

Results are presented of a series of 84 patients receiving renal retransplants over the last 12 years. One year survival rate of patients and transplants was 87.6% and 79.1% respectively, compared with 92.5% and 81.2% for the 783 first grafts performed during the same period. Positive prognostic features were the absence of sensitization, survival of the first transplant for more than 6 months, and the inclusion of cyclosporin in the immunodepressive treatment.

Actuarial Analysis↗