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Biomedical subjects

M Bamberg

Publications and source records attributed to M Bamberg.

At least 217 records · Page 12Linked to original sources
PubMed1982

[Clinical significance of time dose distribution in radiotherapy].

A survey is given of the mathematical and empirical methods allowing to compare different chronological dose distributions; their possibilities and limits are described. The experimental bases of hyper- and superfractionation and the clinical experiences gained hitherto with multiple daily irradiations are communicated; radiotherapy with high individual fractions and long term irradiation are shortly explained. Finally some hints are given for the further development and the practical use of not typical fractionation schemes.

Humans↗
PubMed1981

[Therapy-induced osteosarcoma in Hodgkin's disease].

Patients treated for Hodgkin's disease are exposed to increased risk for second malignancies, a fact which has been well documented in the past decade. Most of these malignancies are hematologic neoplasms, and only rarely have radiation induced sarcomas of the soft tissues or bone been reported. A case with a complication of this kind is described and the implications are discussed.

Adolescent↗
PubMed1981

Diffuse and multicentric brain tumors -- correlation of histological, clinical and CT appearance.

In 14 cases of diffuse astrocytoma, glioblastoma and cerebral lymphoma CT was compared to the gross anatomy and their histology at corresponding levels. Diffuse spread of tumor even in areas of considerable increase of cellular density are not recognizable in CT including application of contrast medium. Circumscribed and frequently multiple foci inside of diffuse areas of gliomatosis may have necrosis and extensive vascular changes including haemorrhage. These foci alone are demonstrable by pathological changes in CT and may suggest multiple metastatic growth or vascular lesions. True unconnected multiple lesions in gliomas are rare as can be demonstrated by intensive histological investigations but occur in cerebral lymphomas.

Aged↗
PubMed1981

Misonidazole as a radiosensitizer in the radiotherapy of glioblastomas and oesophageal cancer. Pharmacokinetic and clinical studies.

Since May 1978 the hypoxic-cell radiosensitizer, misonidazole (MIS), has been under clinical investigation in a phase III trial with multiple doses of the drug in 11 patients with brain tumours (seven glioblastomas, four recurrent brain tumours) and three patients with oesophageal carcinoma. The doses of MIS administered were usually well tolerated but the principal toxicities observed were peripheral neuropathy as well as nausea and vomiting was completely reversible. The incidence of neuropathy was not related to the pharmacological parameters of plasma level or half-life. Pharmacological assessment by high-pressure liquid chromatography included assays of plasma, urine and cerebrospinal fluid. The demethylated product, Ro-05-9963, was detected as the major metabolite. Peak plasma levels were obtained one to four hours after administration of MIS, with a half-life of five to ten hours. Cerebrospinal fluid levels of MIS correlated well with those of the plasma. MIS was mainly excreted as the demethylated metabolite, but less than 40% of the given dose could be recovered. The results obtained suggest that the present MIS dosage for glioblastoma patients results in a low plasma level with no observable therapeutic effect.

Adult↗
PubMed1981

[Clinical manifestations and therapy of dysgerminomas (author's transl)].

Due to improved graduated surgery techniques and large-field radiotherapy applied in all cases, the ovarial dysgerminoma has become a disease showing a high rate of recoveries. Under consideration of their own medical records, the authors present the relevant epidemiologic and clinical parameters, establish a diagnosis programme and develop a therapeutic concept which also wants to take into account the individual requirements of patients regarding their age and their prognosis.

Adolescent↗
PubMed1980

[Radiation-induced kidney diseases after treatment of juvenile neoplasms].

3 children with malignant tumors in one kidney were treated with radiation in doses of 30 (3 weeks), 35 (6 weeks), and 33 Gy (8 weeks). The clinical and histological findings of radiation-induced nephritis from 2 children are demonstrated. In the third case radiation was performed because of adrenocortical carcinoma. 10,5 years after radiation the child developed a renal cell carcinoma.

Adult↗
PubMed1980

[Therapy and prognosis of the medulloblastoma: progress through late irradiation techniques (author's transl)].

Thirty patients with histologically established medulloblastoma were postoperatively irradiated at the radiological center in Essen. The patients were divided into two groups. Treatment was nonuniform in the first group consisting of 12 patients irradiated between 1969 and 1973. The second group of 18 patients was treated uniformly as regards the combined neurosurgical and radiological concept, and a new irradiation technique at the 5.7-MeV linear accelerator was employed there. While none of the patients in the first group survived longer than three years, in the second group 12 of 18 patients are in a good general state after a follow-up period between 19 and 60 months.

Adolescent↗
PubMed1980

[Contribution to the technique of abdominal irradiation of non-Hodgkin lymphomas (author's transl)].

Curative radiation therapy in the treatment of non-Hodgkin lymphomas requires a technique of irradiation taking into account as far as possible the complicated conditions of target volumes and critical organs. Technical problems and clinical necessities having been exposed in detail, the methods of irradiation developed till now are discussed. With the possibilities of simplification and individualization of these methods, combined with modern procedures for irradiation planning, a new technique was developed, whose possibilities and limits are represented.

Abdominal Neoplasms↗
PubMed1980

[Contribution to the technique of radiation therapy for the treatment of early stages in ovarian carcinoma (author's transl)].

A new technique for radiation therapy in stage I and II carcinoma of the ovary is presented, intended to cover as homogeneously as possible the paraaortic, subdiaphragmatic and intradiaphragmatic areas of the direct lymphatic pathways as well as the small pelvis. This technique permits to deliver a dose of up to 46 Gy to this target volume, adjuvant chemotherapy being regarded as a convenient complement of such localized radiation therapy. Using a modern interactive system for treatment planning, a combination of 2 a.-p./p.-a. and 2 lateral fields is developed. Individually shaped circular satellites and rectangular satellites serve for protection of the liver and small intestine. Good reproducibility is obtained by means of the simple geometrical form of the fields and satellites.

Aorta, Abdominal↗
PubMed1979

Malignant progression of angioimmunoblastic lymphadenopathy.

In a 79-year-old woman, the progression of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) to malignant lymphoma was observed within one year after diagnosis. Three biopsy specimens from lymph nodes and one tonsil, obtained at intervals of several months, showed an increasing destruction of the tissue architecture and the development of histological criteria for a lymphoid neoplasm, which at autopsy was confirmed as a malignant non-Hodgkin's lymphoma. The demonstration of a chromosomally abnormal clone in lymph node derived and the laboratory findings were in agreement with the histological changes and the sequential clinical deterioation. Initially, a symptom-free interval of eight months was achieved with prednisone therapy. However, this treatment failed after the malignant transformation had become evident.

Aged↗
PubMed1979

Optimal therapy in medulloblastoma.

Twenty-eight children with medulloblastoma (19 boys and 9 girls) were treated at the Departments of Neurosurgery and Radiotherapy in Essen between 1969 and 1977, and were followed prospectively after surgical treatment and postoperative irradiation. Because different radiation techniques had been used, these patients were divided into two groups, one given a limited irradiation volume and the other irradiation of the entire central nervous system. The results obtained in the former group were inferior to those in the latter. All living patients in the seond group are in good condition. Special attention is paid to the technique of irradiation and the factors which may influence prognosis. Even after the relatively short follow up period of one to five years, it may be concluded that high-dose irradiation of the entire central nervous system considerably improved the prognosis of medulloblastoma.

Adolescent↗
PubMed1979

[Local recurrences in keratoid squamous cell carcinomas of the oral cavity: incidence, causes and therapy after a curative primary treatment (author's transl)].

The frequency of local recurrences in keratoid squamous cell carcinomas of the oral cavity is analyzed in view of the following criteria: Irradiation technique, volume of the primary tumor, irradiation parameters considering the factor of dose and time. The values of the dose, measured by ret, were calculated using the Ellis-formula modified by Gabriel-Jürgens et al. A focal dose of 1,700 ret is recommended for Stage T1 carcinomas of the tongue, a dose of 1,900 ret for the stages T2 and T3. The importance of the concept of nominal standard dose is emphasized with regard to its clinical application. Surgery seems to be superior to the renewal of radiation therapy in the treatment of recurrences.

Adult↗