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Biomedical subjects

M Babić

Publications and source records attributed to M Babić.

At least 19 recordsLinked to original sources
PubMed1998

Carcinoembryonic antigen (CEA) in colonic inflammatory-regenerative and dysplastic epithelial lesions.

AIM: Immunohistochemical study of carcinoembryonic antigen (CEA) distribution in inflammatory-regenerative and dysplastic changes of bowel mucosa. The relationship between the presentation of CEA and the intensity of inflammatory-regenerative and dysplastic processes in the flat colon mucosa was also examined. METHODS: Biopsy specimens from 105 patients were examined: 45 classified as inflammatory-regenerative and 60 as dysplastic (21 mild, 23 moderate, and 16 severe dysplasia). The expression of CEA was assessed on the basis of location, quantity, and intensity of CEA immunostaining, by counting antigen-positive cells, and the presence of antigen in the lumen of crypts and glycocalyx on the surface of the mucosa. Using a semiquantitative method, antigen staining intensity was defined as weak, moderate, and intense. RESULTS: The quantity of CEA in columnar, goblet mucous, and undifferentiated cells, as well as in the glycocalyx on the surface of the mucosa and in the crypts' content increased proportionally with the intensity of epithelial dysplasia. In inflammatory-regenerative lesions, CEA was located in the apical and supranuclear part of the cytoplasm, and in the dysplastic mucosa, in lateral and basal parts of the cells. CONCLUSION: The quantity of immunohistochemically demonstrable CEA and its intracellular distribution changed in the colon mucosa during the transition from regenerative to dysplastic epithelial lesions. The intensity of CEA expression was closely related to the intensity of dysplastic lesion.

Adult↗
PubMed1997

Mandibular growth pattern in Turner's syndrome.

In a group of 15 women with 45,X chromosome constitution, mandibular growth type was investigated by using both linear and angular measurements. The sum of the saddle, articular and gonial angle, lower gonial angle and y-axis was significantly greater. In addition the posterior-anterior facial height ratio in women with Turner's syndrome was significantly smaller than in the controls (61 women with 46,XX chromosome constitution), indicating a tendency to backward and downward growth changes in the mandible, caused by an X chromosome deficiency.

Adult↗
PubMed1995

[Multiple intracranial aneurysms and asymmetrical circle of Willis].

In a consecutive series of 268 patients harboring saccular aneurysms confirmed by digital subtraction angiography (DSA) all major blood vessels of the brain, 36 patients (13.4%) with multiple aneurysms were identified. Majority of them (around 58%) were between 40 to 60 years of age, around 22% were below 40 years of age, but no was younger than 30 years of age. The asymmetric Willis circle was identified in 26 patients (74.2%) A hypoplastic A1 segment of the anterior cerebral artery was revealed in 10 patients; a combination of the hypoplastic A1 segment and the fetal type of the posterior communicating artery with a hypoplastic P1 segment of the posterior cerebral artery were found in 9 cases, while 7 patients had only the fetal posterior communicating artery. A suggestion was put that the asymmetric circle of Willis, prenatal or acquired in postnatal life is inclined of developing aneurysm (multiple aneurysms) only if there exist a hemodynamic stress in postnatal life producing degenerative lesions of the circle of Willis at the site of the augmented hemodynamic vascular wave.

Adult↗
PubMed1995

[Multiple neoplasms].

This paper describes observation on multiple carcinomas, with emphasis on double carcinomas of the lungs and other organs. The paper presents four cases of multiple neoplasmas and goes on to discuss eventual etiopathogenesis of multiple malignancies. Of the four cases presented in this paper, three cover double carcinoma of the throat and lungs, and in the fourth, double carcinoma of the lung and bladder. Three of the cases covered relate to metachronous carcinoma and the fourth case to synchronous carcinoma.

Humans↗
PubMed1993

Comparative cephalometric analysis in patients with X-chromosome aneuploidy.

The influence of abnormal sex-chromosome constitution on cranial growth, shape and position of the craniofacial structures was analysed. Reduced cranial growth was found in women with Turner's syndrome (45 XO chromosome constitution) and in men with Klinefelter's syndrome (47 XXY chromosome constitution). Lack of or an extra X chromosome produced opposite effects on cranial-base flexion, jaw displacement and maxillary and mandibular inclination to the anterior cranial base. An extra X chromosome affected deviation in sagittal jaw relation while lack of an X chromosome influenced mandibular shape.

Adult↗
PubMed1993

Mesiodistal dimension of permanent teeth in men with Klinefelter's syndrome.

The effects of an extra chromosome on tooth size were investigated and compared to male and female controls, respectively. Mesiodistal dimensions in men with Klinefelter's syndrome were generally found to be decreased when compared to the male controls. A more pronounced inhibitory effect of an extra X chromosome was observed in the case of incisors and canines, indicating a varied influence on this chromosomal anomaly on dental growth.

Adult↗
PubMed1991

An extra X chromosome effect on craniofacial morphogenesis in men.

A comparative study of the craniofacial complex in men with an extra X chromosome, and normal male and female individuals was carried out using cephalometric radiography. The anterior cranial base, anterior and posterior facial height, maxillary base and ascending ramus were found to be significantly decreased in men with Klinefelter syndrome when compared to the male control group. Significant differences in the lengths of mandibular base and posterior cranial base were not found. When compared to the female control, all structures examined were significantly increased, except for the maxillary base.

Adult↗
PubMed1991

[Ultrasonic diagnosis of abscesses in tubercular spondylitis of the vertebrae].

Over the period of the last year morbidity of TBC spondylitis of vertebrae due to orthopaedic research in Special clinical orthopaedic hospital Lovran, is found to be increasing once again. In consideration of difficulties of citing TBC abscess of vertebrae in several cases, to help ourselves we have tried to solve this problem with ultrasound. In the last two years 15 patients with TBC spondylitis of vertebrae have been examined. From these, inflammation process was located in thoracal part of vertebrae at 7 patients, and at 8 patients in lumbar part. After result evolution, we have found out that abscesses located in abdominal part could have been cited with ultrasound. With the present degree of accoutrements abscesses in thoracal part located close to spine couldn't be cited by this method of research. The reason was absorption of ultrasound waves in bony structures of torax. By guidance of ultrasound it is possible to accomplish puncture of abscess's sack.

Abscess↗
PubMed1991

[A study of sagittal jaw relationships in patients with Klinefelter's syndrome].

Lateral cephalometric radiographs were used to study sagittal jaw relationships in 22 cases with Klinefelter's syndrome. The following angles were measured: SNA, SNB and ANB. Depending on the size of SNA and SNB angles, all cases investigated were classified in the following groups: bimaxillary prognathism, bimaxillary orthognathism or retrognathism; maxillary prognathism combined with mandibular orthognathism; maxillary orthognathism combined with mandibular prognathism or retrognathism; maxillary retrognathism combined with mandibular prognathism, orthognathism, or retrognathism. The mean value of the ANB angle of the whole group was -0.20 degrees indicating the skeletal class III jaw relationship. Out of 22 cases investigated, 45.4% showed bimaxillary prognathism, and 27.3% had a combination of the maxillary orthognathism and mandibular prognathism. 27.3% of all cases investigated belonged to the remaining groups.

Cephalometry↗
PubMed1990

Phenotype of two males with abnormal Y chromosomes.

Two infertile males with sex chromosomal abnormalities and mosaic karyotype, 45,X/46,X,dic(Yq) and 45,X/46,X,ring(Y), had considerably changed physical findings, including tooth sizes and craniofacial dimensions. Spermatogenesis was preserved with abnormal meiotic chromosomal behaviour. Mosaic karyotype and structurally changed Y chromosome in both cases had an influence on physical parameters. Tests were normally developed and spermatogenesis was preserved but depressed in later stages.

Adult↗
PubMed1984

Ontogenetic changes in protein dephosphorylating activity of the cytosolic compartment of rat erythrocytes.

Total casein phosphatase activity of erythrocytes from one-month-old rats was separated by DEAE-cellulose chromatography into three peaks--E1, E2 and E3--and only into two peaks--E1 and E3--when the erythrocyte donors were six- and 12-month-old rats. The activity of E1 (Mr 330 K) decreased continuously in erythrocytes during the first year of postnatal life. E2 (Mr 230 K) also decreased and completely disappeared from the cells of 12-month-old rats. E3 (Mr 180 K) was the dominant molecular form in the cytosol of erythrocytes during the first year of life. It decreased only up to six months of life. In this form E3 seems to be cooperative with respect to the substrate and to inhibitor molecules. The decrease of its kinetic parameters (Vmax and K0.55) was also found during postnatal ontogenesis. E3 isolated from erythrocytes of older rats (6 and 12 months) was more susceptible to inhibitory effect of pyrophosphate and to the change of ionic strength of eluting buffer than the enzyme from one-month-old rats. 0.2 mol.1(-1) NaCl lowered Mr of E3 phosphatase from 180 K to 128 K only in older rats.

Aging↗
PubMed1984

Chromatographic resolution and characterization of different casein phosphatase activities from the cytosolic compartment of rat erythrocytes.

Casein phosphatase activity in the cytosol of erythrocytes, taken from 1-month-old rats, is associated with three chromatographically distinct peaks: E1, E2 and E3. The dominant molecular form was E3 phosphatase, molecular weight 180,000 dalton, which increased in the cytosol of erythrocytes as compared to the value found in the same compartments of reticulocytes. The enzyme had the pH optimum at 6.5 and seemed to be positively cooperative with respect to substrate and negatively cooperative with respect to pyrophosphate, the most potent inhibitor. E1 and E2 casein phosphatases seem to be remnant activities in erythrocytes as compared to the values found in the cytosol of reticulocytes.

Animals↗