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Biomedical subjects

M Baba

Publications and source records attributed to M Baba.

At least 757 records · Page 42Linked to original sources
PubMed1987

[Role of natural killer cells in the antimetastatic effect of defibrinogenation with batroxobin].

The antimetastatic effects of defibrinogenation with batroxobin were investigated in normal mice and in mice with depressed or activated natural killer (NK) cell activity. Batroxobin inhibited the formation of lung metastases after intravenous inoculation of the F10 subline of B16 melanoma. Inhibition of NK activity by treatment of mice with anti-asialo GM1 antibody abrogated the antimetastatic effects of Batroxobin. Conversely, augmentation of NK cell activity by poly I:C plus treatment with batroxobin produced additive antimetastatic effects. Studies on the mechanism of interaction between Batroxobin and NK cells revealed that Batroxobin treatment did not affect splenic NK activity in vitro. From these data, it was found that the antimetastatic effects of batroxobin are dependent on the level of NK activity in the host.

Animals↗
PubMed1987

[Stress distribution in the brain--numerical simulation by the finite element method].

The analysis of the deformation of brain and distribution of stress caused by the compression from outside would be interesting and also useful for the better understanding of the pathophysiology in the cases of intracranial hematoma and other space occupying lesions. The computerized numerical simulation using the finite element method was carried out to analyze these problems. A simple brain model of two dimensions, that was composed of the inner surface of skull, brain and lateral ventricles, was utilized and it was divided into 101 triangular elements for the calculation of finite element method by a 16-bit personal computer. The model of brain was compressed in two different ways; one was a subdural hematoma type where the force of compression was distributed over relatively wide area and the other was a epidural hematoma type where compression was localized to smaller area. In both types, the brain was compressed on the left fronto-temporal region. The deformation of brain in the subdural hematoma type model was that corresponding to the hematoma of crescent shape just as seen on the CT scan of actual case. The lateral ventricle of affected side was deformed more markedly than that of contralateral side. The midline structure of the brain was shifted to normal side and shift was larger in the portion anterior to the lateral ventricles. The stress was distributed from the area beneath the hematoma to remote location in the affected hemisphere but the propagation of stress was blocked by the falx and it was very small in the contralateral hemisphere.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain↗
PubMed1987

[Pre-operative staging in advanced gastric cancer by ultrasound; with special reference to para-aortic lymph node metastases].

Extraluminal cancer spreadings such as peritoneal dissemination, liver metastases, lymph node metastases and infiltration to surrounding organs were examined in 236 patients with gastric cancer by ultrasound (US). Peritoneal dissemination was found in 36 of 236 cases. Ascites, nodules in the cul-de-sac and thickened wall of the transverse colon could be detected by US in 24 of 36 cases (sensitivity of 67%). Liver metastases were detected in 18 out of 23 cases (78%). Infiltration to the surrounding organs, mainly to the pancreas, was impossible to demonstrate by US. Sensitivity was 44% (17/39). Lymph node metastases in the region around the celiac axis were indicated in 30 of 40 cases (75%) by US. Para-aortic nodal metastases were also detected in 27 of 34 cases (79%). Ultrasonic images of para-aortic lymph node metastases were classified into four figures: plate type, sandwich type, unilateral multiple type, unilateral solitary type. These types were not necessarily the same in indication of laparotomy, selection of combined or adjuvant therapy, significance of nodal dissection and also prognosis. Solitary involved para-aortic node near the left renal vein should be removed in a case free from peritoneal dissemination or liver metastases. Ultrasound could be very useful in screening patients with gastric cancer for peritoneal dissemination, liver metastases and lymph node metastases.

Aorta↗
PubMed1987

Lymph drainage originating from the lower esophagus and gastric cardia as measured by radioisotope uptake in the regional lymph nodes following lymphoscintigraphy.

Lymph drainage originating from the lower esophagus and gastric cardia was determined using uptake of radioisotope (RI) in the regional lymph nodes in 19 patients with primary cancer at these sites. On the day prior to operation, 99m Tc colloid solution was injected submucosally in the distal esophagus or gastric cardia during endoscopy. The regional lymph nodes were removed at operation and RI uptake of individual nodes was measured in a well-type scintillation counter. Uptake was expressed as the amount per nodal weight. After radioactive colloid was injected into the lower esophagus, high RI uptake was common in both the mid-mediastinal and abdominal nodes, suggesting that lymph originating from the lower esophagus drains in both a superior and inferior direction. On the other hand, after radioactive colloid was injected into the gastric cardia, high RI uptake was never demonstrated in mediastinal lymph nodes suggesting that direct mediastinal lymph flow from the gastric cardia is rare. These results support clinical observations on the distribution of lymph nodal metastases in patients with lower esophageal and gastric cardia malignancies. As a diagnostic tool for lymph nodal metastases, however, lymphoscintigraphy is unreliable.

Abdomen↗