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Biomedical subjects

M Büsing

Publications and source records attributed to M Büsing.

51 records · Page 3Linked to original sources
PubMed1991

[Postoperative monitoring of transplanted kidneys using color Doppler sonography].

In 52 renal transplant patients a prospective study was carried out to compare the validity of szintigraphy and color-duplex-sonography for demonstrating the renal blood flow. In 49 cases the questions bout intra-allograft blood flow could be answered. In two cases szintigraphy was unable to make a right evidence. Angiodynography is a non invasive method to demonstrate the blood flow in renal allografts and is able to replace the szintigraphy.

Blood Flow Velocity↗
PubMed1978

[Experimental aspects of pathogenesis and prophylaxis of gastric stress ulcers (author's transl)].

The prophylactic efficacy of various treatments was examined in porcine haemorrhagic shock [13] by measuring total and regional gastric blood flow with radioactive Microspheres. All 24 animals of the control-group (no treatment) developed extensive haemorrhagic lesions of the stomach. Total gastric blood flow fell almost by 90% during shock. By methods improving the circulation during heamorrhagic shock, a nearly total prevention of gastric stress lesions was possible. After splanchnicectomy (n = 7) and by application of the H2-receptor antagonist Cimetidine (n = 8) total gastric blood flow during haemorrhagic shock fell only by 38% and 44%, respectively, when compared to control values before shock. Only 2 piglets of these both groups developed minor changes, whereas in all others no lesions were seen macroscopically or histologically. Conversely truncal vagotomy (n = 9), which impairs gastric blood flow, had no prophylactic effect on the occurence of gastric mucosal lesions, induced by haemorrhagic shock. -- This study supports the suggestion, that gastric ischaemia due to sympathetic overactivity especially in corpus and fundus of the stomach plays an important role in the pathogenesis of gastric stress lesions. An improvement of gastric blood flow during shock could become a useful treatment in man.

Animals↗
PubMed1977

[The effect of antacids on stress-induced lesions of the gastric mucosa in the piglet (author's transl)].

After administration of antacids, gastric stress lesions due to hemorrhagic shock appear in the pig stomach quicker and more markedly than in animals which have been similarly treated with an indifferent substance or not at all. However, once treated, the administration of antacids seems to favor the healing of mucosal lesions after the end of the stress. At the same time it was observed that after administration of antacids in hemorrhagic shock, the serum gastrin level rises and does not remain constant, as in the control group. An attempt is made to explain the favorable effect of antacids on the genesis of hemorrhagic stress lesions in the pig's stomach through this observation.

Animals↗
PubMed1977

Experimental gastric sympathectomy: an effective prophylaxis of gastric stress lesions.

Fifteen mini-pigs were bled to a mean aortic blood pressure of 40 mm Hg and maintained at that level for three hours. The control group consisted of eight animals with shock for three hours, while the test group was comprised of seven animals with a similar shock period but which had undergone splanchnicectomy 14 days earlier. In all animals a stimulated gastric secretion test was performed three days before and eight days after splanchnicectomy. All animals in the control group showed severe gastric mucosal lesions after shock. Conversely, the piglets with splanchnicectomy developed no changes (five animals) or only minor changes (two animals). The efficacy of splanchnicectomy was confirmed by a stimulated gastric secretion test in which basal acid output did not change after operation, but peak acid output increased significantly. This study suggests that gastric splanchnicectomy prevents gastric ulceration following experimental shock.

Animals↗
PubMed1976

[Effect of truncal vagotomy on the occurence of gastric mucosal lesions induced by hemorrhagic shock in piglets (author's transl)].

3 groups of total 37 mini-pigs have been bled to a mean aortic blood pressure of 40 mm Hg for three hours (Norton et al., 1972): Group I: hemorrhagic shock along (n = 15) Group II: right thoracotomy prior to shock without vagotomy (n = 4) Group III: right thoracotomy prior to shock with truncal vagotomy right above diaphragm (n = 15) 3 animals died during shock. All others showed severe mucosal hyperaemia and hemorrhage after shock, which intensified in animals without vagotomy during 8-24 hours. Gastric mucosal lesions of vagotomized animals did not differ to those of group I and II, when the animals were killed 4-8 hours after shock. However, there was a significant reduction of early changes after 12-24 hours, when compared to groups I and II. This study shows, that truncal vagotomy has no effect on the occurence of gastric mucosal lesions, which are induced by hemorrhagic shock in piglets, but prevents these from developing into severe bleeding peptic ulceration.

Animals↗
PubMed1976

[Lose-dose treatment with vitamin A in prevention of stress ulcer in swine].

Hemorrhagic shock in 8 piglets (mean AoBP 40 mm Hg for 3 h) was followed by severe stress-induced gastric mucosal lesions (Gr-I). When vitamin A was administered simultaneously (50,000 IE/kg = Gr. II, n = 6 and 5,000 IE/kg = Gr. III, n = 7) during the procedure, no stress lesions were observed. The study shows that the simultaneous application of vitamin A during hemorrhagic shock, in a reasonable clinical dosage, protects the gastric mucosa against stress-induced lesions.

Animals↗